A5041918610- Music and Audio Processing
- Semantic Web and Ontologies
- Music Technology and Sound Studies
- Digital Humanities and Scholarship
- Diverse Musicological Studies
- Scientific Computing and Data Management
- Research Data Management Practices
- Library Science and Information Systems
- Service-Oriented Architecture and Web Services
- Distributed and Parallel Computing Systems
- Monoclonal and Polyclonal Antibodies Research
- Geographic Information Systems Studies
- Digital and Traditional Archives Management
- Human Mobility and Location-Based Analysis
- Web Data Mining and Analysis
- Natural Language Processing Techniques
- T-cell and B-cell Immunology
- Advanced Database Systems and Queries
- Multimedia Communication and Technology
- Immune Cell Function and Interaction
- Biomedical Text Mining and Ontologies
- Anomaly Detection Techniques and Applications
- Digital Transformation in Industry
- Academic and Historical Perspectives in Psychology
- Advanced Data Storage Technologies
University of Oxford
2016-2025
GlaxoSmithKline (United Kingdom)
2011-2020
Science Oxford
2019
University of Pavia
2015
University of Southampton
2001-2012
Middlesex University
1991
North Middlesex Hospital
1988
Middlesex Hospital
1987
The W3C Semantic Sensor Network Incubator group (the SSN-XG) produced an OWL 2 ontology to describe sensors and observations — the SSN ontology, available at http://purl.oclc.org/NET/ssnx/ssn. can in terms of capabilities, measurement processes, deployments. This article describes ontology. It further gives example use recent research projects.
This paper introduces the Zooniverse citizen science project and software framework, outlining its structure from an observatory perspective: both as observable web-based system in itself, example of a platform iteratively developed according to real-world deployment used at scale. We include details technical architecture Zooniverse, including mechanisms for data gathering across operation, access, analysis. consider lessons that can be drawn experience designing running how this might...
The W3C Semantic Sensor Network Incubator group (the SSN-XG) produced an OWL~2 ontology to describe sensors and observations --- the SSN ontology. can in terms of capabilities, measurement processes, deployments. This article describes It further gives example use recent research projects.
CD40 ligand (CD40L), a surface molecule which can be expressed by T cells, mast cells and basophils, has been shown to involved in the control of B cell proliferation, immunoglobulin class switching as well activation monocytes cells. We demonstrate that CD40L also constitutively eosinophils from an hypereosinophilic patient or, upon activation, eosinophilic line EOL-3 normal blood eosinophils. Eosinophils were able induce, conjunction with IL-4, CD40L-dependent proliferation vitro. These...
Although thyroglobulin (Tg), the thyroid prohormone, is well known as a T cell dependent autoantigen in human and experimental autoimmune disease, very little about molecular basis of Tg recognition by cells. In this paper, we have characterized epitopes recognized two clonotypically distinct, murine autoreactive hybridomas, CH9 ADA2. vitro iodination preparation which was deficient vivo organified iodine first used to confirm our previous observation that these cells recognize...
We have used two clonotypically distinct thyroglobulin (Tg)-specific, I-Ak restricted monoclonal T cell populations to investigate the role of thyroid peroxidase-catalyzed iodination in Tg recognition by autoreactive cells. The results showed that these cells could recognize only it was sufficiently iodinated. Unlike normal mouse Tg, noniodinated unable induce significant lesions but trigger production autoantibodies. In experiments, importance iodination-related epitopes emphasized...
Sensing devices are increasingly being deployed to monitor the physical world around us. One class of application for which sensor data is pertinent environmental decision support systems, e.g., flood emergency response. For these applications, readings need be put in context by integrating them with other sources about surrounding environment. Traditional systems predicting and detecting floods rely on methods that significant human resources. In this paper we describe a semantic web...
Lymphocyte activation gene [LAG]-3 is an immune checkpoint and its expression identifies recently activated lymphocytes that may contribute to inflammation. We investigated the role of LAG-3 by analysing function in cells from blood tissue patients with ulcerative colitis [UC].The phenotypic properties LAG-3+ T were determined flow cytometry, qRT-PCR single-cell RNA-sequencing. quantified correlated disease activity. The functional effects tested using a depleting anti-LAG-3 monoclonal...
Abstract Digital technologies have changed the way supply chain operations are structured. In this article, we conduct systematic syntheses of literature on impact new chains and related cyber risks. A taxonomic/cladistic approach is used for evaluations progress in area integration Industrial Internet Things Industry 4.0, with a specific focus mitigation An analytical framework presented, based critical assessment respect to issues types risk technologies. This paper identifies dynamic...
This article brings together the contribution of participants in a Short-Term Scientific Mission (STSM) COST Action EarlyMuse (CA21161) which took place at IMF-CSIC Barcelona (June 2024). The discussions involved different aspects projects with digital music edition, annotation, analysis, and problems related to preservation heritage, particular attention situation Ukraine. diverse geographical professional background expertise authors provides, their respective sections article, rich...
Over the past two centuries, terms like hidden, absent, masked, disappeared, invisible, and missing have described heritage that is no longer visible. These apply to both tangible intangible elements, spanning natural cultural domains. Heritage itself represents a huge array of categories, all which can hidden aspects. pieces may been due many reasons, some accidentally, purposefully erased, others modified, forgotten or destroyed by man nature even for they always hidden. The term...
The Epstein-Barr virus-induced receptor 2 (EBI2) is a constitutively active seven-transmembrane receptor, which was recently shown to orchestrate the positioning of B cells in follicle. To date, no ligands, endogenously or synthetic, have been identified that modulate EBI2 activity. Here we describe an inverse agonist, GSK682753A, selectively inhibited constitutive activity with high potency and efficacy. In cAMP-response element-binding protein-based reporter guanosine...
At a first glance there might appear to be an obvious alignment and overlap between the approaches prescribed by REST Linked Data. On more detailed inspection divergences in scope applicability present themselves, for some aspects, incompatibility. In this paper we investigate these similarities differences suggest coupling is worthy of third look: combination as flexible environment which developer can focus on domain driven applications.
The majority of volunteers participating in citizen science projects perform only a few tasks each before leaving the system. We designed an intervention strategy to reduce disengagement 16 different projects. Targeted users who had left system received emails that directly addressed motivational factors affect their engagement. Results show participants receiving were significantly more likely return productive activity when compared control group.
Multiple governmental agencies and private organisations have made commitments for the colonisation of Mars. Such requires complex systems infrastructure that could be very costly to repair or replace in cases cyber attacks. This paper surveys deep learning algorithms, IoT security risk models, established mathematical formulas identify best approach developing a dynamic self adapting system predictive analytics supported with Artificial Intelligence Machine Learning real time intelligence...
Abstract Manuscripts are a crucial form of evidence for research into all aspects premodern European history and culture, there numerous databases devoted to describing them in detail. This descriptive information, however, is typically available only separate data silos based on incompatible models user interfaces. As result, it has been difficult study manuscripts comprehensively across these various platforms. To address this challenge, team manuscript scholars computer scientists worked...
Interleukin 5 (IL-5) is the key cytokine involved in regulating production and many of specialized functions mature eosinophils including priming, adhesion, survival. We have generated a point mutant human IL-5, IL-5 (E12K), which devoid agonist activity both TF-1 cell proliferation assay eosinophil adhesion assay. However, (E12K) potent specific antagonist these IL-5-dependent functional responses. In receptor binding cross-linking studies wild-type exhibit virtually identical properties....
The CoAKTinG project aims to advance the state of art in collaborative mediated spaces for Semantic Grid. This paper presents an overview hypertext and knowledge-based tools that have been deployed augment exiting environments, ontology is used exchange structure, promote enhanced process tracking, aid navigation resources before, after, during a collaboration. While primary focus has supporting e-Science, this also explores similarities application technologies as part human-centered design...
Building upon a collection with functionality for discovery and analysis has been described by Lynch as `layered' approach to digital libraries. Meanwhile, corpora have grown in size, their is necessarily supplemented automated application of computational methods, which can create layers information intricate complex those within the content itself. This combination - aggregating homogeneous collections, specialised analyses, new observations requires flexible systems implementation enables...
As a scoping exercise in the design of our Social Machines Observatory we consider observation "in wild", as illustrated through two scenarios. More than identifying and classifying individual machines, argue that need to study interactions between machines observe them throughout their lifecycle. We suggest purpose may be key notion help identify composed systems, mixed methods will required. This provides basis for later work on how instrument ecosystem.