A5063788658- Parasites and Host Interactions
- Asthma and respiratory diseases
- Eosinophilic Disorders and Syndromes
- Eosinophilic Esophagitis
- Research on Leishmaniasis Studies
- Immune Cell Function and Interaction
- Mast cells and histamine
- Parasite Biology and Host Interactions
- Helminth infection and control
- Parasitic Infections and Diagnostics
- Allergic Rhinitis and Sensitization
- Food Allergy and Anaphylaxis Research
- Urticaria and Related Conditions
- IL-33, ST2, and ILC Pathways
- Monoclonal and Polyclonal Antibodies Research
- Amoebic Infections and Treatments
- Immune Response and Inflammation
- Inflammatory Bowel Disease
- T-cell and B-cell Immunology
- Trypanosoma species research and implications
- Pediatric health and respiratory diseases
- Parasitic Diseases Research and Treatment
- Malaria Research and Control
- Parasitic infections in humans and animals
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
Université de Lille
2009-2022
Inserm
2012-2022
Lille Inflammation Research International Center
2015-2022
Centre Hospitalier Universitaire de Lille
1997-2022
Institute for Translational Research in Inflammation
2017-2022
Eurasanté
2022
Institut Pasteur de Lille
2004-2015
Université Lille Nord de France
2009-2015
Institut Pasteur
2001-2015
Centre National de la Recherche Scientifique
1988-2015
SUMMARY Ebola virus subtype Zaire (Ebo-Z) induces acute haemorrhagic fever and a 60–80% mortality rate in humans. Inflammatory responses were monitored victims survivors of Ebo-Z during two recent outbreaks Gabon. Survivors characterized by transient release plasma interleukin-1β (IL-1β), IL-6, tumour necrosis factor-α (TNFα), macrophage inflammatory protein-1α (MIP-1α) MIP-1β early the disease, followed circulation IL-1 receptor antagonist (IL-1RA) soluble receptors for TNFα (sTNF-R) IL-6...
Interleukin 5 (IL-5) is the main factor that promotes terminal differentiation of eosinophil progenitors (as indicated by colony formation assays), and enhances effector capacity mature eosinophils. IL-5 produced T lymphocytes, CD4-/CD8- mast cells recently, messenger (m)RNA this cytokine has been identified in eosinophils from patients with coeliac disease, asthma, or eosinophilic heart diseases. In study, mRNA immunoreactive protein were detected tissue blood cystitis hypereosinophilic...
Epidermal Langerhans cells (LCs) play a key role in immune defense mechanisms and numerous immunological disorders. In this report, we show that percutaneous infection of C57BL/6 mice with the helminth parasite Schistosoma mansoni leads to activation LCs but, surprisingly, their retention epidermis. Moreover, using an experimental model LC migration induced by tumor necrosis factor (TNF)-α, parasites transiently impair departure from epidermis subsequent accumulation as dendritic draining...
Small-subunit (SSU) rRNA gene sequences were obtained by PCR from 12 Blastocystis isolates humans, rats, and reptiles for which elongation factor 1alpha (EF-1alpha) are already available. These new analyzed the Bayesian method in a broad phylogeny including, first time, all available databases. Phylogenetic trees identified seven well-resolved groups plus several discrete lineages that could represent newly defined clades. Comparative analysis of SSU rRNA- EF-1alpha-based maximum-likelihood...
Abstract Prostaglandins (PG) are important modulators of immune and inflammatory responses. We recently demonstrated that the production PGD 2 by helminthic parasite Schistosoma mansoni inhibits migration epidermal Langerhans cells (LC) to draining lymph nodes (DLN). Here, we identify responsible enzyme as being a 28‐kDa glutathione‐S‐transferase (termed Sm28GST). Intradermal injection Sm28GST in wild‐type (WT), but not D prostanoid receptor (DP) 1‐deficient mice abrogates departure LC from...
Allergic asthma is characterized by airway hyperresponsiveness, eosinophilia, and mucus accumulation associated with increased IgE concentrations. We demonstrate here that peroxisome proliferator–activated receptors (PPARs), PPAR-α PPAR-γ, which have been shown recently to be involved in the regulation of various cell types within immune system, decrease antigen-induced lung inflammation, cytokine production, GATA-3 expression as well serum levels antigen-specific a murine model human...
Interleukin 5 (IL-5), the major factor involved in eosinophil differentiation, is produced by T cells or mast cells. In present study, we found that eosinophils infiltrating mucosa of four patients with active coeliac disease also express IL-5 mRNA. No positive signal was obtained normal duodenum tissues and cell infiltrate from submitted to gluten restriction. The identification labeled mucosal as relied on their typical morphology. Moreover, highly purified blood three out eosinophilia...
Intensities of re-infection were monitored at three-monthly intervals after treatment Schistosoma mansoni infections in a group 119 Kenyan schoolchildren, whose levels water contact also observed. 22 children showed high reinfection intensities (>100 eggs per gram faeces) by 12 months treatment, and considered to be susceptible. Out 70 who low during the same period (<30 gram), 35 both total with sites containing infected snails. In these children, relative lack could not attributed...
Abstract Allergic pathologies are often associated with IgE production, mast cell activation, and eosinophilia. PGD2 is the major eicosanoid, among several inflammatory mediators, released by cells. binds to two membrane receptors, D prostanoid receptor (DP)1 DP2, endowed antagonistic properties. In humans, DP2 preferentially expressed on type 2 lymphocytes, eosinophils, basophils mediates chemotaxis in vitro. Although not yet supported vivo studies, thought be important promotion of...
Eosinophils are the source of various immunoregulatory cytokines, but membrane molecules involved in their secretion have not been clearly identified. Here we show that peripheral blood eosinophils from hypereosinophilic patients could express CD86 CD80. The T cell costimulatory molecule CD28 is also detected on eosinophil surface. ligation resulted interleukin (IL)-2 and interferon (IFN)-γ by eosinophils, whereas IL-4, IL-5, IL-10 were detected. In contrast to cells requiring two signals...
Mebendazole was given to four patients with hepatic hydatid disease. In three hydatidosis had remained after surgery, and in the fourth it could not be treated surgically. orally maximum doses of 400-600 mg times a day during courses lasting 21 30 days. Ultrasonic echotomography showed complete regression intrahepatic cysts 13 months all cases. course treatment repeated. also induced clinical improvement progressive lowering concentration specific IgE Echinococcus granulosus. During...
Considerable variations in the distribution of eosinophil populations were revealed by density gradient centrifugation peripheral blood leukocytes from 14 normal subjects and 31 patients with a transient or persistent hypereosinophilia. Such purification procedure enabled us to collect healthy controls, eosinophils (77.1 ± 15.9% SD purity) an appreciable cell recovery (21.7 14.0% SD) densest gradients (‘normodense’ cells). A high degree purity was obtained same gradients, hypereosinophilia...
Highly purified blood platelets from man and rat could be induced into cytotoxic effectors against schistosome larvae by an IgE-dependent mechanism. Such a process implied the existence of receptor for Fc part IgE on surface these elements. Normal platelets, incubated in serum infected individuals as well IgE-rich asthmatic patients, showed similar capabilities. Flow cytofluorometric analysis evidenced that bearing receptors represented subpopulation (20%), percentage which was significantly...