A5068936914- RNA and protein synthesis mechanisms
- RNA Research and Splicing
- RNA modifications and cancer
- Hemoglobin structure and function
- Robotic Mechanisms and Dynamics
- Robot Manipulation and Learning
- Soft Robotics and Applications
- Neonatal Health and Biochemistry
- Erythrocyte Function and Pathophysiology
- Protein Structure and Dynamics
- Heme Oxygenase-1 and Carbon Monoxide
- Prosthetics and Rehabilitation Robotics
- Hemoglobinopathies and Related Disorders
- nanoparticles nucleation surface interactions
- Advanced Chemical Physics Studies
- Bacteriophages and microbial interactions
- Teleoperation and Haptic Systems
- Iterative Learning Control Systems
- Spectroscopy and Quantum Chemical Studies
- Advanced Thermodynamics and Statistical Mechanics
- Piezoelectric Actuators and Control
- Photosynthetic Processes and Mechanisms
- Electron Spin Resonance Studies
- Bacterial Genetics and Biotechnology
- Stroke Rehabilitation and Recovery
Ritsumeikan University
2013-2024
National Kyushu Medical Center
2023-2024
Clinical Research Institute
2023-2024
Yokohama City University
2024
MRC Laboratory of Molecular Biology
2011-2021
National Hospital Organization Kyushu Cancer Center
2019
Medical Research Council
1995-2015
Tokyo Institute of Technology
2013
Kyoto University
1986-2005
Komatsu (Japan)
1996-2005
This paper discusses the dynamical coordination of multiple robot manipulators or a multifingered hand. The coor dination problem is divided into two phases: determining resultant force by robotic mechanisms; internal between mechanisms. used for maintaining dynamic equilibrium and generat ing restoring force. A coordinative control scheme which guarantees object stability proposed, associated with determination forces. to satisfy static frictional constraints related contact stability....
U1 snRNP binds to the 5' exon-intron junction of pre-mRNA and thus plays a crucial role at an early stage splicing. We present two crystal structures engineered sub-structures, which together reveal atomic resolution almost complete network protein-protein RNA-protein interactions within snRNP, show how splice site is recognised by snRNP. The zinc-finger U1-C interacts with duplex between 5'-end snRNA. binding RNA stabilized hydrogen bonds electrostatic backbone around but makes no...
Creation of the splicing catalytic center The fully assembled, precatalytic pre–B spliceosome is not yet formed, even though all pieces are present in this complex. Charenton et al. solved structures human complex, providing detailed mechanistic insights into how helicase Prp28 transfers 5′ splice site messenger RNA precursor from U1 small nuclear ribonucleoprotein (snRNP) to U6 snRNA. pairing with induces a series conformational changes that triggers relocation Brr2 and loading U4 snRNA...
A new definition of grasping and manipulating forces for multifingered robot hands is proposed. First, a short discussion the two-fingered with linear motion given to explain motivation more clearly give basic idea definition. Then, three-fingered hands, based on representation internal force, force defined as an that satisfies static friction constraint. The concept grasp mode also introduced. then fingertip following three conditions: (1) it produces specified resultant (2) not in inverse...
This paper discusses the mechanics of coordinative manipulation by multiple robot manipulators or a multifingered hand. The problem is divided into two phases. One determining resultant force robotic mechanisms, and other internal between them. used for an object subjected external forces environmental constraints. adapting mechanisms to uncertainty variety static friction. A dynamic control scheme proposed forces. optimal defined as that yields minimal norm satisfying frictional promotes...
Human beta-globin was synthesized in Escherichia coli as a cleavable fusion protein, using the expression vector pLcIIFX [Nagai, K. & Thøgersen, H. C. (1984) Nature (London) 309, 810-812]. The protein cIIFX purified to homogeneity and cleaved at junction by blood coagulation factor Xa; authentic liberated. Beta-globin folded vitro reconstituted with heme alpha subunits form 2 beta tetramers. oxygen binding properties of Hb are essentially same those human native Hb. Two mutant Hbs (Hb...