A5043562583- Cancer Cells and Metastasis
- 3D Printing in Biomedical Research
- Cancer survivorship and care
- Cellular Mechanics and Interactions
- Tissue Engineering and Regenerative Medicine
- Pancreatic and Hepatic Oncology Research
- Microtubule and mitosis dynamics
- Cancer, Stress, Anesthesia, and Immune Response
- Effects of Radiation Exposure
- Immune cells in cancer
- Non-Invasive Vital Sign Monitoring
- Cancer Treatment and Pharmacology
- Exercise and Physiological Responses
- Cancer Immunotherapy and Biomarkers
- Healthcare Technology and Patient Monitoring
- Intravenous Infusion Technology and Safety
- Electrospun Nanofibers in Biomedical Applications
University of Copenhagen
2021-2025
Abstract Pancreatic ductal adenocarcinoma (PDAC) patients have a 5-year survival rate of only 8% largely due to late diagnosis and insufficient therapeutic options. Neutrophils are among the most abundant immune cell type within PDAC tumor microenvironment (TME), associated with poor clinical prognosis. However, despite recent advances in understanding neutrophil biology cancer, therapies targeting tumor-associated neutrophils lacking. Here, we demonstrate, using pre-clinical mouse models...
Despite advances in breast cancer diagnosis and treatment of the primary tumor, metastatic tumors remain largely incurable, their growth is responsible for majority cancer-related deaths. There therefore a critical need to identify ways reduce tumor burden increase patient survival. While surgery pharmacological treatments are cornerstones intervention, epidemiological data suggests that physical activity can lower risk development, improve adjuvant tolerance, disease recurrence death. In...
The desmoplastic reaction observed in many cancers is a hallmark of disease progression and prognosis, particularly breast pancreatic cancer. Stromal-derived extracellular matrix (ECM) significantly altered desmoplasia, as such plays critical role driving cancer progression. Using fibroblast-derived matrices (FDMs), we show that cells have increased growth on associated FDMs, when compared to FDMs derived from non-malignant tissue (normal) fibroblasts. We assess the changes ECM...
Postdiagnosis physical activity is associated with improved cancer outcomes, but biological mechanisms mediating anticancer effects remain unclear. Recent findings suggest that physiological adaptations to acute exercise comprise potential effects, these poorly explored in clinical settings. The objective of this study was explore the a single bout on tumor oxygenation and immune cell infiltration patients prostate cancer. Thirty localized were randomized (2:1) either one high-intensity...
Metastatic cancer spread is responsible for most cancer-related deaths. To colonize a new organ, invading cells adapt to, and remodel, the local extracellular matrix (ECM), network of proteins proteoglycans underpinning all tissues, critical regulator homeostasis disease. However, there major lack in tools to study cell behavior within native 3D ECM. Here, an in-house designed bioreactor, where mouse organ ECM scaffolds are perfused populated with that challenged it, presented. Using...
During the metastatic process, breast cancer cells must come into contact with extra-cellular matrix (ECM) at every step. The ECM provides both structural support and biochemical cues, cell–ECM interactions can lead to changes in drug response. Here, we used fibroblast-derived (FDM) perform high throughput screening of 4T1 on organ (lung), see that response differs from treatment plastic. FDMs produce different organs are abundant contains a complex mixture proteins. We also show differences...
Articles| December 01 2000 A comparison of hydrostatic leveling methods in invasive pressure monitoring WP Rice; Rice Search for other works by this author on: This Site PubMed Google Scholar EG Fernandez; Fernandez D Jarog; Jarog Jensen Crit Care Nurse (2000) 20 (6): 20–30. https://doi.org/10.4037/ccn2000.20.6.20 Views Icon Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Facebook Twitter LinkedIn MailTo Tools Cite Get Permissions Citation Rice, Fernandez,...
Cancer Metastasis Highlighting article number 2100684 by Janine T. Erler, Alejandro E. Mayorca-Guiliani and co-workers, this cover represents cancer cells extravasating out of a vessel into decellularized extracellular matrix (ECM) organ scaffold. Upon arriving in the capillary bed, adhere to ECM use it migrate organ. The authors' metastasis model system is based on bioreactor where scaffolds are provided with conditions necessary sustain cell life. Cell-ECM interactions coerce behaving as...