A5070548853- Exercise and Physiological Responses
- Cancer survivorship and care
- Adipose Tissue and Metabolism
- Microbial Inactivation Methods
- Nutrition and Health in Aging
- Childhood Cancer Survivors' Quality of Life
- Lymphatic System and Diseases
- Adipokines, Inflammation, and Metabolic Diseases
- Immune Cell Function and Interaction
- Muscle Physiology and Disorders
- CRISPR and Genetic Engineering
- Cancer, Stress, Anesthesia, and Immune Response
- Viral Infectious Diseases and Gene Expression in Insects
- Testicular diseases and treatments
- Transgenic Plants and Applications
- Microfluidic and Bio-sensing Technologies
- Cancer, Hypoxia, and Metabolism
- Cancer Immunotherapy and Biomarkers
- Toxin Mechanisms and Immunotoxins
- Head and Neck Cancer Studies
- Science, Research, and Medicine
- Dietary Effects on Health
- Muscle metabolism and nutrition
- Fibroblast Growth Factor Research
- Hippo pathway signaling and YAP/TAZ
Copenhagen University Hospital
2013-2024
University of Copenhagen
2012-2022
Rigshospitalet
2012-2022
Psychiatry Region Zealand
2019
San Antonio College
2018
University of Coimbra
2018
Herlev Hospital
2007-2017
Danish National Research Foundation
2015
Capital Region of Denmark
2013
Næstved Sygehus
2012
Regular physical activity protects against the development of breast and colon cancer, since it reduces risk developing these by 25–30%. During exercise, humoral factors are released from working muscles for endocrinal signaling to other organs. We hypothesized that myokines mediate some inhibitory effects exercise on mammary cancer cell proliferation. Serum were collected mice after an bout. Incubation with exercise-conditioned serum inhibited MCF-7 proliferation 52% increased caspase 54%....
Abstract Electroporation of cells with short, high-voltage pulses causes a transient permeabilization cell membranes that permits passage otherwise nonpermeating ions and molecules. In this study, we illustrate how electroporation isotonic calcium can achieve highly effective cancer kill in vivo. Calcium elicited dramatic antitumor responses which 89% treated tumors were eliminated. Histologic analyses indicated complete tumor necrosis. Mechanistically, caused acute ATP depletion likely due...
OBJECTIVE Fibroblast growth factor-21 (FGF-21) is a potent metabolic regulator, which in animal models has been shown to improve glucose metabolism and insulin sensitivity. Recently, FGF-21 was be expressed secreted from murine muscle cells response stimulation. RESEARCH DESIGN AND METHODS We studied muscular expression plasma after acute stimulation young healthy men during hyperinsulinemic- euglycemic clamp. Furthermore, we investigated systemic levels humans with or without resistance...
IL-15 decreases lipid deposition in preadipocytes and the mass of white adipose tissue rats, indicating that may take part regulating this tissue. is expressed human skeletal muscle be a source plasma way regulate mass.The relation between mRNA expression, IL-15, was studied 199 humans divided into four groups on basis obesity type 2 diabetes. Furthermore, using DNA electrotransfer model, we assessed effect overexpression mice.In humans, multiple regression analysis showed negative...
Follistatin is a member of the TGF-β super family and inhibits action myostatin to regulate skeletal muscle growth. The regulation follistatin during physical exercise unclear but may be important because activity major intervention prevent age-related sarcopenia. First, healthy subjects performed either bicycle or one-legged knee extensor exercise. Arterial-venous differences were assessed experiment. Next, mice 1 h swimming, expression was examined in various tissues using quantitative...
Abstract Strong epidemiologic evidence documents the protective effect of physical activity on breast cancer risk, recurrence, and mortality, but underlying mechanisms remain to be identified. Using human exercise–conditioned serum for cell incubation studies murine exercise interventions, we aimed identify factors signaling pathways involved in exercise-dependent suppression cancer. Exercise-conditioned from both women with (n = 20) healthy 7) decreased MCF-7 (hormone-sensitive) MDA-MB-231...
Gene electrotransfer is gaining momentum as an efficient methodology for nonviral gene transfer. In skeletal muscle, data suggest that electric pulses play two roles: structurally permeabilizing the muscle fibers and electrophoretically supporting migration of DNA toward or across permeabilized membrane. To investigate this further, combinations short high-voltage (HV; hundreds V/cm) mainly electrophoretic long low-voltage (LV; tens were investigated in liver, tumor, skin rodent models. The...
Gene electrotransfer is gaining momentum as an efficient methodology for nonviral gene transfer. In skeletal muscle, data suggest that electric pulses play two roles: structurally permeabilizing the muscle fibers and electrophoretically supporting migration of DNA toward or across permeabilized membrane. To investigate this further, combinations short high-voltage (HV; hundreds V/cm) mainly electrophoretic long low-voltage (LV; tens were investigated in liver, tumor, skin rodent models. The...
Cytokines and other peptides are secreted from skeletal muscles in response to exercise function as hormones either locally within the muscle or by targeting distant organs. Such proteins recognized myokines, with prototype myokine being IL-6. Several studies have established a role of these muscle-derived factors important contributors beneficial effects exercise, myokines central our understanding cross talk during after between In study into mechanisms newly defined myokine, CXCL-1, we...
Circulating interleukin (IL)-18 is elevated in obesity, but paradoxically causes hypophagia. We hypothesized that IL-18 may attenuate high-fat diet (HFD)-induced insulin resistance by activating AMP-activated protein kinase (AMPK). studied mice with a global deletion of the α-isoform receptor (IL-18R(-/-)) fed standard chow or HFD. next performed gain-of-function experiments skeletal muscle, vitro, ex vivo, and vivo. show implicated metabolic homeostasis, inflammation, via mechanisms...
IL-6 is secreted from muscles to the circulation during high-intensity and long-duration exercise, where muscle-derived works as an energy sensor increase release of substrates liver adipose tissues. We investigated mechanism involved in exercise-mediated surge exercise. Using interval-based cycling healthy young men, swimming exercise mice, electrical stimulation primary human muscle cells, we explored role lactate production muscular First, observed a tight correlation between both...
Electroporation is used in cancer treatment because of its ability to increase local cytotoxicity e.g. bleomycin (electrochemotherapy) and calcium (calcium electroporation). Calcium electroporation a novel anticancer that selectively kills cells by necrosis, cell death pathway stimulates the immune system due high release antigens "danger signals." In this exploratory study, we aimed investigate whether could initiate an response similar electrochemotherapy. To end, treated immunocompetent...
Neoadjuvant chemotherapy or chemoradiotherapy is used widely before tumour resection in cancer of the gastro-oesophageal junction (GOJ). Strategies to improve treatment tolerability are warranted. This study examined safety and feasibility preoperative exercise training during neoadjuvant these patients.Patients were allocated a standard-care control group an group, who prescribed standard care plus twice-weekly high-intensity aerobic resistance sessions. The primary endpoint was incidence...