A5036575474- Nuclear physics research studies
- Nuclear Physics and Applications
- Adipose Tissue and Metabolism
- Thermoregulation and physiological responses
- Adipokines, Inflammation, and Metabolic Diseases
- Neutrino Physics Research
- Nuclear reactor physics and engineering
- Exercise and Physiological Responses
- Muscle metabolism and nutrition
- Housing, Finance, and Neoliberalism
- Particle physics theoretical and experimental studies
- Sports Performance and Training
- Infrared Thermography in Medicine
- Smart Parking Systems Research
- Healthcare innovation and challenges
- Heat shock proteins research
- Liver Disease Diagnosis and Treatment
- Immune cells in cancer
- Genomics, phytochemicals, and oxidative stress
- Radiation Detection and Scintillator Technologies
- Metabolism, Diabetes, and Cancer
- Urbanization and City Planning
- Law, AI, and Intellectual Property
- Children's Rights and Participation
- Corporate Taxation and Avoidance
Garvan Institute of Medical Research
2018-2024
Baker Heart and Diabetes Institute
2012-2020
Instituto de Física Corpuscular
2011-2017
Universitat de València
2009-2017
Consejo Superior de Investigaciones Científicas
2014-2016
University of Castilla-La Mancha
2006-2012
Universidad de Navarra
2012
Camilo José Cela University
2012
Universidad Publica de Navarra
2012
Universidad El Bosque
2007-2009
Highlights•IL-6 trans-signaling recruits macrophages to adipose tissue in HFD-induced obesity•Blocking IL-6 with sgp130Fc prevents ATM accumulation•Prevention of accumulation obesity does not rescue insulin resistance•Blocking exacerbate resistanceSummaryInterleukin-6 (IL-6) plays a paradoxical role inflammation and metabolism. The pro-inflammatory effects are mediated via "trans-signaling," process where the soluble form receptor (sIL-6R) binds activates signaling inflammatory cells that...
Induction of heat shock protein (HSP)72 protects against obesity-induced insulin resistance, but the underlying mechanisms are unknown. Here, we show that HSP72 plays a pivotal role in increasing skeletal muscle mitochondrial number and oxidative metabolism. Mice overexpressing (HSP72Tg) control wild-type (WT) mice were fed either chow or high-fat diet (HFD). Despite similar energy intake when HSP72Tg compared with WT mice, HFD increased body weight, intramuscular lipid accumulation...
Circulating interleukin (IL)-18 is elevated in obesity, but paradoxically causes hypophagia. We hypothesized that IL-18 may attenuate high-fat diet (HFD)-induced insulin resistance by activating AMP-activated protein kinase (AMPK). studied mice with a global deletion of the α-isoform receptor (IL-18R(-/-)) fed standard chow or HFD. next performed gain-of-function experiments skeletal muscle, vitro, ex vivo, and vivo. show implicated metabolic homeostasis, inflammation, via mechanisms...
The antineutrino spectra measured in recent experiments at reactors are inconsistent with calculations based on the conversion of integral beta recorded ILL reactor. (92)Rb makes dominant contribution to reactor spectrum 5-8 MeV range but its decay properties question. We have studied total absorption spectroscopy. Previously unobserved feeding was seen 4.5-5.5 region and GS found be 87.5(25)%. impact calculated summation method is shown discussed.
Purpose: To determine the effect of water, carbohydrate, and caffeine ingestion on fatigue during prolonged exercise in heat. Methods: Seven endurance-trained cyclists (V˙O2max = 61 ± 8 mL·kg−1·min−1) pedaled for 120 min at 63% V˙O2max a hot-dry environment (36°C; 29% humidity), ingesting either no fluid (NF), water (WAT) to replace 97% losses, same volume 6% carbohydrate-electrolyte solution (CES), or each these treatments along with 6 mg per kilogram body weight (NF + CAFF, WAT CES CAFF)....
The $^{150}\mathrm{Nd}$($^{3}\mathrm{He}$,$t$) reaction at $140$ MeV/u and $^{150}\mathrm{Sm}$($t$,$^{3}\mathrm{He}$) $115$ were measured, populating excited states in $^{150}\mathrm{Pm}$. transitions studied populate intermediate of importance for the (neutrinoless) $\ensuremath{\beta}\ensuremath{\beta}$ decay $^{150}\mathrm{Nd}$ to $^{150}\mathrm{Sm}$. Monopole dipole contributions measured excitation-energy spectra extracted by using multipole decomposition analyses. experimental results...
Purpose: To compare the thermoregulatory responses between constant (CON) and variable-intensity exercise (VAR) in a dry-hot environment (36°C, 29% relative humidity, 2.5 m·s−1 airflow). Methods: In random order, seven endurance-trained, heat-acclimated subjects cycled either at 60% V˙O2max or alternating 1.5 min 90% with 4.5 50% (VAR). Total work output (915 ± 100 kJ) duration (90 min) were identical both trials. Results: Net metabolic heat production was not different trials (394 12 vs...
The effects that rehydrating drinks ingested during exercise may have on anaerobic performance are unclear. This study aimed to determine which of four commercial better maintains leg power and force prolonged cycling in the heat. Seven endurance-trained heat-acclimatized cyclists pedaled for 120 min at 63% maximum oxygen consumption a hot, dry environment (36 °C; 29% humidity, 1.9 m·s –1 airflow). In five randomized trials, exercise, subjects drank 2.4 ± 0.1 L (i) mineral water (WAT; San...
Objective Adipose inflammation and dysfunction underlie metabolic obesity. Exercise improves glycemic control indices, but effects on adipose function are less clear. Accordingly, it was hypothesized that exercise morphometry to reduce in hyperphagic obese mice. Methods Alms1 mutant foz/foz mice housed pairs were fed an atherogenic or chow diet; half the cages fitted with a computer‐monitored wheel for voluntary exercise. Insulin‐induced AKT‐phosphorylation, adipocyte size distribution,...
The accumulation of lipid at ectopic sites, including the skeletal muscle and liver, is a common consequence obesity associated with tissue-specific whole body insulin resistance. Exercise well known to improve resistance by mechanisms not completely understood. We performed lipidomic profiling via mass spectrometry in liver samples from exercise-trained mice decipher changes exercise-induced improvements glucose metabolism. Obesity were induced C57BL/6J high-fat feeding for 4 wk. Mice then...
We investigate the decay of $^{87,88}\mathrm{Br}$ and $^{94}\mathrm{Rb}$ using total absorption $\ensuremath{\gamma}$-ray spectroscopy. These important fission products are $\ensuremath{\beta}$-delayed neutron emitters. Our data show considerable $\ensuremath{\beta}\ensuremath{\gamma}$ intensity, so far unobserved in high-resolution spectroscopy, from states at high excitation energy. also find significant differences with $\ensuremath{\beta}$ intensity that can be deduced existing...
Total absorption spectroscopy is used to investigate the β-decay intensity states above neutron separation energy followed by γ-ray emission in (87,88)Br and (94)Rb. Accurate results are obtained thanks a careful control of systematic errors. An unexpectedly large γ observed all three cases extending well beyond excitation region where penetration hindered low energy. The branching as function compared Hauser-Feshbach model calculations. For (87)Br (88)Br reaches 57% 20%, respectively, could...
Purpose: To investigate the effects of caffeine ingestion on thermoregulation and fluid-electrolyte losses during prolonged exercise in heat. Methods: Seven endurance-trained (V˙O2max = 61 ± 8 mL.kg−1.min−1) heat-acclimated cyclists pedaled for 120 min at 63% V˙O2max a hot-dry environment (36°C; 29% humidity) six occasions: 1) without rehydration (NF); 2) rehydrating 97% sweat with water (WAT); 3) same volume 6% carbohydrate-electrolytes solution (CES); or combining these treatments 6 mg...
The beta decays of $^{86}\mathrm{Br}$ and $^{91}\mathrm{Rb}$ have been studied using the total absorption spectroscopy technique. radioactive nuclei were produced at Ion Guide Isotope Separator On-Line facility in Jyv\"askyl\"a further purified JYFLTRAP. are considered to be major contributors decay heat reactors. In addition, was used as a normalization point direct measurements mean gamma energies released fission products by Rudstam et al. assuming that this well known from...
Studies suggest the gut microbiota contributes to development of obesity and metabolic syndrome. Exercise alters composition diversity is protective these maladies. We tested whether effects exercise are mediated through fecal components assessment body metabolism in recipients transplantation (FMT) from exercise-trained (ET) mice fed normal or high-energy diets. Donor C57BL/6J were a chow high-fat, high-sucrose diet (HFHS) for 4 wk induce glucose intolerance. Mice divided into sedentary...
It has been suggested that interleukin-6 (IL-6) produced by adipocytes in obesity leads to liver insulin resistance, although this hypothesis never definitively tested. Accordingly, we did so generating adipocyte-specific IL-6-deficient (AdipoIL-6 −/− ) mice and studying them the context of diet-induced genetic obesity. Mice carrying two floxed alleles IL-6 (C57Bl/6J) were crossed with Cre recombinase-overexpressing driven adiponectin promoter generate AdipoIL-6 mice. littermate controls fed...
Abstract Aspects of team players' performance are negatively affected when ~ 2% body mass is lost by perspiration. Although such dehydration likely reached during summer practice in outdoors sports, it unclear if achieved the indoor sports. We assessed fluid and electrolyte deficits elite players for following sports: soccer ( n =9), basketball =11), volleyball =10), handball =13). Morning hydration status was estimated measuring urine specific gravity. Sweat rate calculated from changes...