A5041213698- Pancreatitis Pathology and Treatment
- Pancreatic and Hepatic Oncology Research
- Gastrointestinal disorders and treatments
- Gallbladder and Bile Duct Disorders
- Pediatric Hepatobiliary Diseases and Treatments
- Pancreatic function and diabetes
- Neuroendocrine Tumor Research Advances
- Liver Disease Diagnosis and Treatment
- Esophageal and GI Pathology
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Appendicitis Diagnosis and Management
- Gastric Cancer Management and Outcomes
- Abdominal Surgery and Complications
- Cancer Genomics and Diagnostics
- IgG4-Related and Inflammatory Diseases
- Diabetes and associated disorders
- Esophageal Cancer Research and Treatment
- Intestinal Malrotation and Obstruction Disorders
- Gastroesophageal reflux and treatments
- Bariatric Surgery and Outcomes
- Biliary and Gastrointestinal Fistulas
- MicroRNA in disease regulation
- Childhood Cancer Survivors' Quality of Life
- Congenital Anomalies and Fetal Surgery
- Gastrointestinal Tumor Research and Treatment
Dartmouth–Hitchcock Medical Center
2016-2025
Dartmouth College
2008-2024
NHS Grampian
2023-2024
University of Saint Mary
2024
University of California, San Francisco
2023
University of Chicago
2023
Medical University of South Carolina
2016-2023
University of Aberdeen
2023
University of Cincinnati
2023
The Ohio State University Wexner Medical Center
2023
<h3>Background</h3> Recurrent acute pancreatitis (RAP) and chronic (CP) are associated with alcohol consumption cigarette smoking. The etiology of RAP CP is complex, effects smoking may be limited to specific patient subsets. We examined the current prevalence use their association in patients evaluated at US referral centers. <h3>Methods</h3> North American Pancreatitis Study 2, a multicenter consortium 20 centers, prospectively enrolled 540 CP, 460 RAP, 695 controls from 2000 2006. Using...
The diagnosis of chronic pancreatitis remains challenging in early stages the disease. This report defines diagnostic criteria useful assessment patients with suspected and established pancreatitis. All current procedures are reviewed, evidence-based statements provided about their utility limitations. Diagnostic for classified as definitive, probable, or insufficient evidence. A (STEP-wise; survey, tomography, endoscopy, pancreas function testing) algorithm is proposed that proceeds from a...
<h3>Objective</h3> To compare patients with chronic pancreatitis (CP) constant pain patterns to CP intermittent patterns. <h3>Methods</h3> This was a prospective cohort study conducted at 20 tertiary medical centers in the USA comprising 540 subjects CP. Patients were asked identify their from five (A–E) defined by temporal nature (intermittent or constant) and severity of (mild, moderate severe). Pain pattern types compared respect variety demographic, quality life (QOL) clinical...
Chronic pancreatitis (CP) is historically defined as an irreversible inflammatory condition of the pancreas leading to varying degrees exocrine and endocrine dysfunction. Recently however, paradigm for diagnosis has changed in that it breaks with traditional clinicopathologic-based definition disease, focusing instead on diagnosing underlying pathologic process early disease course managing syndrome more holistically change natural minimize adverse effects. Currently, most accepted...
Objectives: Chronic pancreatitis (CP) has a profound independent effect on quality of life (QOL). Our aim was to identify factors that impact the QOL in CP patients. Methods: We used data 1,024 patients enrolled three NAPS2 studies. Information demographics, risk factors, co-morbidities, disease phenotype, and treatments obtained from responses structured questionnaires. Physical mental component summary (PCS MCS, respectively) scores generated using Short Form-12 (SF-12) survey were assess...
Acute pancreatitis (AP), defined as acute inflammation of the pancreas, is one most common diseases gastrointestinal tract leading to hospital admission in United States. It important for clinicians appreciate that AP heterogenous, progressing differently among patients and often unpredictable. While experience symptoms lasting a few days, almost one-fifth will go on complications, including pancreatic necrosis and/or organ failure, at times requiring prolonged hospitalization, intensive...
OBJECTIVES: Organ failure (OF) is a main cause of death in severe acute pancreatitis (SAP). Our primary aim was to evaluate the morbidity and mortality patients admitted with SAP no OF (NOF), single (SOF), multiple (≥2) (MOF). METHODS: Medical records 207 consecutive Mayo Clinic between 1992 2001 were reviewed. defined according Atlanta classification categorized three groups—NOF, SOF, MOF. Primary outcomes in-hospital mortality, duration hospitalization, need for intensive care unit (ICU),...
Induction of heat shock protein (HSP)72 protects against obesity-induced insulin resistance, but the underlying mechanisms are unknown. Here, we show that HSP72 plays a pivotal role in increasing skeletal muscle mitochondrial number and oxidative metabolism. Mice overexpressing (HSP72Tg) control wild-type (WT) mice were fed either chow or high-fat diet (HFD). Despite similar energy intake when HSP72Tg compared with WT mice, HFD increased body weight, intramuscular lipid accumulation...
CFTR is a dynamically regulated anion channel. Intracellular WNK1-SPAK activation causes to change permeability and conductance characteristics from chloride-preferring bicarbonate-preferring channel through unknown mechanisms. Two severe mutations (CFTRsev) cause complete loss of function result in cystic fibrosis (CF), genetic disorder affecting sweat glands, nasal sinuses, lungs, pancreas, liver, intestines, male reproductive system. We hypothesize that those disrupt the mechanisms...
Abstract Introduction: Pancreatic ductal adenocarcinoma (PDAC) is a lethal malignancy. Diagnosis and management of PDAC are hampered by the absence sensitive specific disease biomarkers. MicroRNAs (miRNA) noncoding regulatory RNAs involved in initiation progression human cancers. In this study, we sought to determine whether miR-10b could serve as biomarker for PDAC. Experimental Design: miRNA expression was characterized fluorescence-based situ hybridization using locked nucleic...
<h3>Objective</h3> Minimally invasive surgical necrosectomy and endoscopic necrosectomy, compared with open might improve outcomes in necrotising pancreatitis, especially critically ill patients. Evidence from large comparative studies is lacking. <h3>Design</h3> We combined original newly collected data 15 published unpublished patient cohorts (51 hospitals; 8 countries) on pancreatic for pancreatitis. Death rates were patients undergoing versus minimally or necrosectomy. To adjust...