A5025034153- Neuroendocrine Tumor Research Advances
- Pancreatic and Hepatic Oncology Research
- Neuropeptides and Animal Physiology
- Lung Cancer Research Studies
- Cancer, Stress, Anesthesia, and Immune Response
- Helicobacter pylori-related gastroenterology studies
- Pancreatitis Pathology and Treatment
- Peptidase Inhibition and Analysis
- Liver Disease Diagnosis and Treatment
- Cancer Research and Treatments
- Hepatocellular Carcinoma Treatment and Prognosis
- Pancreatic function and diabetes
- Epigenetics and DNA Methylation
- Inflammatory Bowel Disease
- Cancer Genomics and Diagnostics
- Gastric Cancer Management and Outcomes
- Phagocytosis and Immune Regulation
- Cancer Immunotherapy and Biomarkers
- Chemokine receptors and signaling
- Diabetes and associated disorders
- Cancer, Lipids, and Metabolism
- Cancer Cells and Metastasis
- Liver Disease and Transplantation
- Microscopic Colitis
- Liver physiology and pathology
Georgetown University
2016-2025
Harefield Hospital
2025
Guy's and St Thomas' NHS Foundation Trust
2025
Georgetown University Medical Center
2017-2024
Georgetown Lombardi Comprehensive Cancer Center
2016-2023
Roche (United Kingdom)
2021
Penn State Milton S. Hershey Medical Center
2006-2020
Georgetown-Howard Universities Center for Clinical and Translational Science
2017
Pennsylvania State University
2004-2016
MedStar Georgetown University Hospital
2015
OBJECTIVES: This study examined the relationships between wealth and income selected racial ethnic differences in health. METHODS: Cross-sectional data on a national sample of 9744 men women aged 51 through 61 from 1992 Health Retirement Survey were analyzed to examine association socioeconomic status functional among those with hypertension, diabetes, heart condition, arthritis. RESULTS: Compared Whites, African Americans report higher rates arthritis, while Hispanics hypertension diabetes...
OBJECTIVES: Low vitamin D status may be associated with Crohn's disease. A pilot study was performed in patients mild-to-moderate disease to determine the dose of needed raise serum levels above 40 ng/ml. METHODS: Patients were evaluated for severity symptoms using activity index (CDAI) and (150–400 CDAI scores) entered into (n=18). Vitamin D3 oral therapy initiated at 1,000 IU/d after 2 weeks, escalated incrementally until patients' concentrations reached ng/ml 25(OH)D3 or they taking 5,000...
The early diagnosis of cancer is the critical element in successful treatment and long-term favorable patient prognoses. high rate mortality mainly attributed to tendency for late diagnoses as symptoms may not occur until disease has metastasized, well lack effective systemic therapies. Late often associated with timely sensitive imaging modalities. promise nanotechnology presently limited by inability simultaneously seek, treat, image cancerous lesions. This study describes design synthesis...
In Brief A workshop sponsored by the National Institute of Diabetes and Digestive Kidney Diseases (NIDDK) Cancer (NCI) on "Pancreatitis-Diabetes-Pancreatic Cancer" focused risk factors chronic pancreatitis (CP) diabetes mellitus (DM) development pancreatic ductal adenocarcinoma (PDAC). Sessions were held (a) an overview problem PDAC; (b) CP as a factor (c) DM (d) pancreatogenic, or type 3c, DM; (e) genomic associations CP, DM, (f) surveillance high-risk populations early detection (g)...
Abstract Background Although 20 pancreatic cancer susceptibility loci have been identified through genome-wide association studies in individuals of European ancestry, much its heritability remains unexplained and the genes responsible largely unknown. Methods To discover novel risk possible causal genes, we performed a transcriptome-wide study Europeans using three approaches: FUSION, MetaXcan, Summary-MulTiXcan. We integrated summary statistics from 9040 cases 12 496 controls, with gene...
Background Survival for cardiac arrest remains poor, and the use of extracorporeal cardiopulmonary resuscitation (ECPR) has been suggested as a potential therapy to improve outcomes. Harefield Hospital performing ECPR over decade; however outcomes have historically poor. Methods A retrospective analysis was performed all cases at between April 2018 2023. new structured system including systematic screening process, strict exclusion criteria, assessment adequacy through physiological stop...
Endogenous opioids and opioid antagonists have been shown to play a role in healing repair of tissues. In an open-labeled pilot prospective trial, the safety efficacy low-dose naltrexone (LDN), antagonist, were tested patients with active Crohn's disease.Eligible subjects histologically endoscopically confirmed disease activity index (CDAI) score 220-450 enrolled study using 4.5 mg naltrexone/day. Infliximab was not allowed for minimum 8 wk prior initiation. Other therapy that at stable dose...
The present study reports the first evidence that gastrointestinal peptide gastrin stimulates growth of several human pancreatic cancer cells in culture and tumors transplanted to nude mice. Gastrin promoted all cell lines tested at a dose comparable binding affinity, providing for physiologically relevant receptor. stimulatory effects were blocked by CCK-B/gastrin receptor antagonist L-365,260 not CCK-A L-364,718. Growth PANC-1 inhibited L-365,260, suggesting is tonically produced...
Chronic pancreatitis (CP) is a rare but debilitating condition with an 8-fold increased risk of developing pancreatic cancer. In addition to the symptoms that come from loss endocrine and exocrine function in CP, management chronic pain problematic. We previously showed CCK-receptor antagonist called proglumide could decrease inflammation, acinar-ductal metaplasia, fibrosis murine models CP. hypothesized would be safe diminish caused by A Phase 1 open-labeled safety study was performed...
Introduction: We describe the first reported case of auto-brewery syndrome complicating liver transplantation, wherein a patient was temporarily removed from transplant list not due to ethanol consumption but rather spontaneous ethanolic fermentation within gastrointestinal tract. Auto-brewery (ABS) is rare metabolic condition where microbiota dysbiosis leads microbial under anaerobic, high carbohydrate conditions. Because no alcohol directly consumed by patient, this often referred as...
Hepatitis C is a common chronic infection. Nonsteroidal anti-inflammatory drugs are commonly ingested both over-the-counter and by prescription. This case report describes three cases where ibuprofen use leads to marked rise in hepatic transaminases with one repeating on rechallenge. These support the recommendation of acetaminophen over nonsteroidal drug patients hepatitis C.
Pancreatic adenocarcinoma is a fatal malignancy that ranks as the fourth most common cause of cancer-related mortality in United States. The median survival after diagnosis 3-6 months, with 5-year rate 3% or less. In spite treatment efforts surgery, radiation, and chemotherapy, remains unchanged. this study, we discovered an endogenous opioid peptide, [Met5]-enkephalin, inhibited growth human pancreatic cancers vitro; view pentapeptide's action it has been termed factor (OGF). OGF was found...
There is an unmet need for safe and effective medicines to treat children with Crohn's disease. Recently, investigations have shown association between endogenous opioid peptides inflammatory cells.
Pancreatic ductal adenocarcinomas (PDACs) constitutively express the G-protein-coupled cholecystokinin B receptor (CCKBR). In this study, we identified DNA aptamers (APs) that bind to CCKBR and describe their characterization targeting efficacy. Using dual SELEX selection against "exposed" peptides CCKBR-expressing PDAC cells, a pool of APs was identified. Further downselection based on predicted structures properties, selected eight for initial characterizations. The bound specifically...