A5025792760- Influenza Virus Research Studies
- Respiratory viral infections research
- Vaccine Coverage and Hesitancy
- Mechanical Circulatory Support Devices
- Transplantation: Methods and Outcomes
- Cardiac, Anesthesia and Surgical Outcomes
- COVID-19 epidemiological studies
- Organ Transplantation Techniques and Outcomes
- Cardiac and Coronary Surgery Techniques
- Cardiac Valve Diseases and Treatments
- Animal Disease Management and Epidemiology
- Cardiac Ischemia and Reperfusion
- Pneumonia and Respiratory Infections
- Cardiac Structural Anomalies and Repair
- Viral Infections and Outbreaks Research
- Viral gastroenteritis research and epidemiology
- Acute Kidney Injury Research
- Anesthesia and Neurotoxicity Research
- Cardiac pacing and defibrillation studies
- Cardiac Arrest and Resuscitation
- Heart Failure Treatment and Management
- SARS-CoV-2 and COVID-19 Research
- Consumer Retail Behavior Studies
- Hepatitis C virus research
- Takotsubo Cardiomyopathy and Associated Phenomena
Harefield Hospital
2015-2025
Guy's and St Thomas' NHS Foundation Trust
2021-2025
Seqirus (United States)
2021-2025
Royal Brompton & Harefield NHS Foundation Trust
2015-2021
University Health Network
2021
University of Toronto
2021
University of Wolverhampton
2007
London Chest Hospital
2002-2003
Royal London Hospital
1999-2002
Abstract Background In the US, adults aged ≥65 years are recommended to receive an adjuvanted or higher dose influenza vaccine. Adjuvanted (aIIV) and high-dose (HD-IIV) inactivated vaccines were similarly effective against in several studies based on diagnostic codes. However, less is known about their relative vaccine effectiveness (rVE) laboratory-confirmed they have never been compared a randomized study. We assessed rVE of vs. PCR-confirmed at Kaiser Permanente Northern California...
Background Survival for cardiac arrest remains poor, and the use of extracorporeal cardiopulmonary resuscitation (ECPR) has been suggested as a potential therapy to improve outcomes. Harefield Hospital performing ECPR over decade; however outcomes have historically poor. Methods A retrospective analysis was performed all cases at between April 2018 2023. new structured system including systematic screening process, strict exclusion criteria, assessment adequacy through physiological stop...
Seasonal influenza viruses undergo unpredictable changes, which may lead to antigenic mismatch between circulating and vaccine strains a reduced effectiveness. A continuously updated knowledge of strain circulation seasonality is essential optimize the effectiveness vaccination campaigns. We described global epidemiology 2009 A(H1N1)p 2020 COVID-19 pandemic.Influenza virological surveillance data were obtained from WHO-FluNet database. determined median proportion cases caused by different...
Recommending co-administration of influenza and COVID-19 vaccines has emerged as a strategy to enhance vaccination coverage. This study describes the policy on uptake in Europe, United Kingdom, States, Canada between 2019 2023. We collected data from governmental websites, national health organizations, newspapers. Influenza coverage among persons ≥65 years rates ≥60 or general population were using databases, ECDC database, ourworldindata.org Descriptive analyses used. 30/32 (94%) countries...
The COVID-19 pandemic, along with disruptions to routine medical care, brought renewed urgency public health messaging about the importance of influenza vaccination. This retrospective cohort study used a database linked claims and electronic record data evaluate clinical demographic characteristics vaccination history associated changes in vaccine uptake following start pandemic. Influenza was examined six seasons (2015−2016 through 2020−2021). Individuals were grouped by five before...
Abstract Background Egg-based influenza vaccine viruses often acquire egg-adaptive mutations in the hemagglutinin protein that can alter their antigenicity and may contribute to reduced effectiveness. Cell-based manufacturing avoids egg adaptation. We recently demonstrated improved effectiveness of cell-based quadrivalent vaccines (QIVc) compared with egg-based (QIVe) preventing test-confirmed during 2017-18 2019-20 seasons population aged 4-64 years United States. The objective this study...
Abstract Background Estimation of burden averted is useful to contextualize the impact differentiated vaccines. Traditional influenza vaccine production in eggs can introduce egg-adaptive mutations. Cell-based vaccines avoid egg-adaptation, potentially improving match circulating viruses and thereby effectiveness (VE). This study modeled public health if all people aged 0-64 years vaccinated United States during 2022-2023 season had received either cell-based inactivated quadrivalent...
Influenza vaccine viruses grown in eggs may acquire egg-adaptive mutations that reduce antigenic similarity between and circulating influenza decrease effectiveness. We compared cell- egg-based quadrivalent vaccines (QIVc QIVe, respectively) for preventing test-confirmed over 3 US seasons (2017-2020). Using a retrospective test-negative design, we estimated the relative effectiveness (rVE) of QIVc vs QIVe among individuals aged 4 to 64 years who had an acute respiratory or febrile illness...
The adaptation of influenza seed viruses in egg culture can result a variable antigenic vaccine match each season. cell-based quadrivalent inactivated (IIV4c) contains grown mammalian cell lines rather than eggs. IIV4c is not subject to egg-adaptive changes and therefore may offer improved protection relative egg-based vaccines, depending on the degree with circulating viruses. We summarize effectiveness (rVE) versus vaccines (IIV4e) prevent influenza-related medical encounters (IRMEs) from...
Abstract The 10 years between the last influenza pandemic and start of severe acute respiratory syndrome coronavirus 2 have been marked by great advances in our ability to follow occurrence determine vaccine effectiveness (VE), largely based on widespread use polymerase chain reaction assay. We examine results, focusing mainly data from United States inactivated vaccines. Surveillance has expanded, resulting increased characterize circulating viruses their impact. surveillance often...
Cell-based quadrivalent inactivated influenza vaccines (IIV4c) avoid egg-adaptive mutations found in egg-based production, improving vaccine effectiveness (VE). Studies demonstrate improved VE for IIV4c relative to (IIV4).
Research on influenza burden in adults has focused crude subgroups with cut-points at 65-years, limiting insight into how varies increasing age. This study describes the incidence of influenza-related outpatient visits, emergency room (ER) and hospitalizations, along healthcare resource use complications aging adult population.
Recent advances in the management of patients with adult congenital heart disease (ACHD) have led to an increased number who may develop failure and require transplantation (HTx). The purpose this study was evaluate early mid-term postoperative outcomes after HTx use Organ Care System (OCS) a cohort ACHD transplanted at our tertiary center. All consecutive performed from January 2015 2019 institution were analyzed. Donor recipient preoperative characteristics, intraoperative course,...
Venovenous extracorporeal membrane oxygenation (VV-ECMO) is increasingly being used in acutely deteriorating patients with end-stage lung disease as a bridge to transplantation (BTT). It can allow critically ill recipients remain eligible for transplants (LTx) while reducing pretransplant deconditioning. We analyzed early- and midterm postoperative outcomes of on VV-ECMO BTT the impact preoperative posttransplant survival outcomes.All consecutive LTx performed at our institution between...
Abstract Background : Establishing a large study network to conduct influenza vaccine effectiveness (IVE) studies while collecting appropriate variables account for potential bias is important; the most relevant should be prioritized. We explored impact of confounders on IVE in DRIVE multi‐country sites conducting test‐negative design (TND) studies. Methods constructed directed acyclic graph (DAG) map relationship between vaccination, medically attended infection, confounders, and other...
While studies have evaluated factors influencing the risk of severe influenza outcomes, there is limited evidence on additive impact having multiple and how this varies by age. Patients ≥18 years age in United States were retrospectively 5 seasonal cohorts during 2015-2020 seasons. Patient-level electronic medical records linked to pharmacy claims used ascertain covariates outcomes. Multivariable logistic regression models fitted for overall population subgroups evaluate association...
Abstract Background This study estimated the relative vaccine effectiveness (rVE) of MF59-adjuvanted trivalent influenza (aTIV) versus high-dose inactivated (HD-TIV) for prevention influenza-related medical encounters (IRMEs) during 2019–2020 United States (US) season stratified by cumulative number risk factors. A secondary objective evaluated outpatient IRMEs and influenza- pneumonia-related hospitalizations. Methods retrospective cohort included US adults ≥65 years old vaccinated with...