A5053725425- Influenza Virus Research Studies
- Respiratory viral infections research
- Maternal Mental Health During Pregnancy and Postpartum
- Meta-analysis and systematic reviews
- Mental Health Treatment and Access
- Mental Health Research Topics
- Health Systems, Economic Evaluations, Quality of Life
- SARS-CoV-2 and COVID-19 Research
- Maternal and Perinatal Health Interventions
- Health disparities and outcomes
- Child and Adolescent Psychosocial and Emotional Development
- Cardiac Health and Mental Health
- Health Policy Implementation Science
- Ethics in Clinical Research
- Delphi Technique in Research
- Pneumonia and Respiratory Infections
- Machine Learning in Healthcare
- Vaccine Coverage and Hesitancy
- Health and Wellbeing Research
- Health and Well-being Studies
- Clinical practice guidelines implementation
- Attachment and Relationship Dynamics
- scientometrics and bibliometrics research
- Aging and Gerontology Research
- Homicide, Infanticide, and Child Abuse
Seqirus (United States)
2025
Jewish General Hospital
2018-2024
McGill University
2020
Researchers increasingly use meta-analysis to synthesize the results of several studies in order estimate a common effect. When outcome variable is continuous, standard meta-analytic approaches assume that primary report sample mean and deviation outcome. However, when skewed, authors sometimes summarize data by reporting median one or both (i) minimum maximum values (ii) first third quartiles, but do not deviation. To include these meta-analysis, methods have been developed from reported...
Randomised controlled trials are increasingly conducted as embedded, nested, or using cohorts routinely collected data, including registries, electronic health records, and administrative databases, to assess if participants eligible for the trial facilitate recruitment, deliver an embedded intervention, collect outcome a combination of these purposes. This report presents Consolidated Standards Reporting Trials (CONSORT) extension randomised data (CONSORT-ROUTINE). The was developed look at...
Real-world evidence (RWE) increasingly informs public health and healthcare decisions worldwide. A large database has been created (“Integrated Dataset”) that integrates primary care electronic medical records with pharmacy claims data on >123 million US patients since 2014. This article describes the components of Integrated Dataset evaluates its representativeness to population potential use in evaluating influenza vaccine effectiveness. Representativeness (2014−2019) was evaluated by...
Abstract Background Selective reporting of results from only well-performing cut-offs leads to biased estimates accuracy in primary studies questionnaire-based screening tools and meta-analyses that synthesize results. Individual participant data meta-analysis (IPDMA) sensitivity specificity at each cut-off via bivariate random-effects models (BREMs) can overcome this problem. However, IPDMA is laborious depends on the ability successfully obtain datasets, BREMs ignore correlation between...
Among young adults, diabetes affects increasing numbers of persons and this is a cause for alarm as public health concern. Paleolithic nutrition depression are some the factors underlying condition. This study, therefore, aims at examining relationship between nutrition, lifestyle, mental well-being, among individuals aged 18 40 in Kenya. In case, research surveyed level junk food intake well levels, awareness diabetes, amount physical training participants had, to illustrate link poor diet,...
Background: Egg-based influenza vaccine production can lead to the accumulation of mutations that affect antigenicity. The mammalian cell-based inactivated quadrivalent (IIV4c) may improve effectiveness compared with egg-based vaccines. This study estimated relative (rVE) IIV4c versus (IIV4e) in preventing influenza-related medical encounters (IRME) among children and adolescents during 2019–2020 US season. Methods: retrospective cohort used a dataset linking primary specialty care...
ABSTRACT Background Adults ≥ 65 years of age have suboptimal influenza vaccination responses compared to younger adults due age‐related immunosenescence. Two vaccines were specifically developed enhance protection: MF59‐adjuvanted trivalent vaccine (aIIV3) and high‐dose egg‐based (HD‐IIV3e). Methods In a retrospective cohort study conducted using US electronic medical records linked claims data during the 2019–2020 season, we relative effectiveness (rVE) aIIV3 with HD‐IIV3e standard‐dose...
Abstract Background Mutations occurring during egg-based influenza vaccine production may affect effectiveness. The mammalian cell-based quadrivalent inactivated (IIV4c) demonstrated improved protection relative to vaccines in prior seasons. This study estimated the effectiveness (rVE) of IIV4c versus standard-dose (IIV4e) preventing influenza-related medical encounters (IRMEs) 2019–2020 US season. Methods retrospective cohort was conducted using a dataset linking electronic records with and...
MF59®-adjuvanted trivalent inactivated influenza vaccine (aIIV3) and high-dose (HD-IIV3) elicit an enhanced immune response in older adults compared to standard, quadrivalent vaccines (IIV4). We sought determine the relative effectiveness (rVE) of aIIV3 versus IIV4 HD-IIV3 preventing influenza-related medical encounters this retrospective cohort study involving ≥65 years with ≥1 health condition during 2017–2018 2018–2019 seasons. Data were obtained from primary specialty care electronic...
Higher rates of influenza-related morbidity and mortality occur in individuals with underlying medical conditions. To improve vaccine effectiveness, cell-based technology for influenza manufacturing has been developed. Cell-derived inactivated quadrivalent vaccines (cIIV4) may protection seasons which egg-propagated viruses undergo mutations that affect antigenicity. This study aimed to estimate the relative effectiveness (rVE) cIIV4 versus egg-derived (eIIV4) preventing encounters...
Age-related immunosenescence may impair the immune response to vaccination in older adults. Adjuvanted influenza vaccines are designed overcome senescence This study estimated relative vaccine effectiveness (rVE) of MF59-adjuvanted trivalent inactivated (aIIV3) vs egg-derived quadrivalent (IIV4e) and high-dose (HD-IIV3) preventing influenza-related medical encounters 2019-2020 US season.This retrospective cohort used electronic records linked pharmacy claims data. The population included...