A5101426800- Fungal Infections and Studies
- Congenital Diaphragmatic Hernia Studies
- Congenital Anomalies and Fetal Surgery
- Antifungal resistance and susceptibility
- Pediatric Hepatobiliary Diseases and Treatments
- Tracheal and airway disorders
- Esophageal and GI Pathology
- Intestinal Malrotation and Obstruction Disorders
- Congenital gastrointestinal and neural anomalies
- Neonatal Respiratory Health Research
- Nail Diseases and Treatments
- Plant Pathogens and Fungal Diseases
- Liver Diseases and Immunity
- Dysphagia Assessment and Management
- Gallbladder and Bile Duct Disorders
- Dermatology and Skin Diseases
- Hernia repair and management
- Organ Transplantation Techniques and Outcomes
- Inflammation biomarkers and pathways
- Gastrointestinal disorders and treatments
- Plant-Microbe Interactions and Immunity
- Skin Protection and Aging
- Neuroendocrine Tumor Research Advances
- Liver Disease Diagnosis and Treatment
- Streptococcal Infections and Treatments
Second Military Medical University
2013-2025
Shanghai Changzheng Hospital
2015-2025
XinHua Hospital
2016-2025
Shanghai Jiao Tong University
2016-2025
University of Pittsburgh
2022
Pennsylvania State University
2004-2016
Harvard University
2005-2015
Massachusetts General Hospital
2014-2015
Shanghai Institute of Nutrition and Health
2014
Southwest University
2013
Cutaneous warts caused by human papillomavirus are benign proliferative lesions that occur at any ages in lives. Updated, comprehensive and systematic evidence-based guidelines to guide clinical practice urgently needed.We collaborated with multidisciplinary experts formulate this guideline based on evidences of already published literature, focusing 13 questions elected a panel experts. We adopted Grading Recommendations Assessment, Development Evaluation (GRADE) system form classification...
Abstract Background Transplanting autologous patient‐derived enteric neuronal stem/progenitor cells ( ENSC s) is an innovative approach to replacing missing neurons in patients with Hirschsprung disease HSCR ). Using eliminates immunologic and ethical concerns raised by other cell sources. However, whether postnatal aganglionic bowel permissive for transplanted s from can be successfully isolated, cultured, vivo remains unknown. Methods isolated the ganglionic intestine of Ednrb −/− mice ‐...
Biliary atresia (BA) is a severe chronic cholestasis disorder of infants that leads to death if not treated on time. Neonatal hepatitis syndrome (NHS) another leading cause neonatal confounding the diagnosis BA. Recent studies indicate altered bile acid metabolism closely associated with liver injury and cholestasis. In this study, we systematically measured metabolome in plasma BA, NHS, healthy controls. Liver acids were also using biopsy samples from 48 BA 16 NHS undergoing operative...
Abstract Comprehensive reference genomes are needed for the classification and functional characterization of human skin microbiota. Here, we established microbiome genome (HSMG) protein (HSMP) catalogs by integrating 739 newly sequenced 2,520 published samples, along with two microbial catalogs. The HSMG includes 3547 prokaryotic species, which 1556 (43.87%) unidentified, HSMP contains 39,283,339 nonredundant proteins, 64.8% poorly characterized. Using as a reference, identified distinct...
Objective: To compare the effectiveness and safety of da Vinci robot-assisted conventional laparoscopic surgery for hiatal hernia (HH) treatment in children after repair esophageal atresia (EA).
Recurrent tracheoesophageal fistula (rTEF) is a complex complication after the repair of esophageal atresia (EA) and remains challenge because difficulties in preoperative management substantial rates mortality morbidity reoperation. By reviewing single institution's experience rTEF assessing outcome, we aimed to provide an optimal approach for managing evaluate growth feeding problems reoperations. The medical records 35 patients with treated at institution from June 2012 December 2015 were...
Pancreatic ductal adenocarcinomas (PDACs) constitutively express the G-protein-coupled cholecystokinin B receptor (CCKBR). In this study, we identified DNA aptamers (APs) that bind to CCKBR and describe their characterization targeting efficacy. Using dual SELEX selection against "exposed" peptides CCKBR-expressing PDAC cells, a pool of APs was identified. Further downselection based on predicted structures properties, selected eight for initial characterizations. The bound specifically...
Tinea capitis is still common in developing countries, such as China. Its pathogen spectrum varies across regions and changes over time.This study aimed to clarify the current epidemiological characteristics of tinea China.A multicentre, prospective descriptive involving 29 tertiary hospitals China was conducted. From August 2019 July 2020, 611 patients with were enrolled. Data concerning demography, risk factors fungal tests collected. When necessary, pathogens further identified by...
Cryptococcus neoformans causes cryptococcal meningitis, which is frequent in patients with HIV/AIDS, especially less-developed countries. The incidence of meningitis close to 1 million each year globally.
We have a long-standing interest in nuclear protease which appears to be involved carcinogenesis. recently identified the as high temperature requirement factor A 1 (HtrA1), also known Prss11, is member of an oxidative stress-response family proteases. HtrA1 has been classified secreted TGFbeta signaling, but recent work shown tumor suppressor. Here we show that processed forms are found intracellularly and intranuclearly, active intranuclear form shows approximately Mr 29,000. Further,...
Global distribution patterns of Cladophialophora carrionii, agent human chromoblastomycosis in arid climates Africa, Asia, Australia, Central-and South-America, were compared with similar data the vicarious Fonsecaea spp., agents disease tropical rain forests. Population diversities among 73 C. carrionii strains and 60 three species analyzed for rDNA ITS, partial β-tubulin, amplified fragment-length polymorphism (AFLP) fingerprints. Populations differed significantly between continents....
Whether the alternated microbiota in gut contribute to risk of allograft rejection (AR) and pulmonary infection (PI) setting lung transplant recipients (LTRs) remains unexplored. A prospective multicenter cohort LTRs was identified four centers. Paired fecal serum specimens were collected divided into AR, PI, event-free (EF) groups according diagnosis at sampling. Fecal samples determined by metagenomic sequencing. And metabolites cytokines detected paired analyze potential effect altered...
Nonsyndromic biliary atresia (BA) is a rare polygenic disease, with autoimmunity, virus infection and inflammation thought to play roles in its pathogenesis. We conducted genome-wide association study 336 nonsyndromic BA infants 8900 controls. Our results validated the of rs17095355 ADD3 risk (odds ratio (OR) = 1.70, 95% confidence interval (95% CI) 1.49-1.99; p 4.07 × 10-11). An eQTL analysis revealed that allele was associated increased expression ADD3. Single-cell RNA-sequencing data...
Biliary atresia (BA) is a rare neonatal cholestatic disorder caused by obstruction of extra- and intra-hepatic bile ducts. If untreated, progressive liver cirrhosis will lead to death within 2 years. Early diagnosis operation improve the outcome significantly. Infants with hepatitis syndrome (NHS) present similar symptoms, confounding early BA. The lack noninvasive diagnostic methods differentiate BA from NHS greatly delays surgery infants, thus deteriorating outcome. Here we performed...