A5100675004- Fungal Infections and Studies
- Antifungal resistance and susceptibility
- Nail Diseases and Treatments
- Plant Pathogens and Fungal Diseases
- Anesthesia and Neurotoxicity Research
- Peptidase Inhibition and Analysis
- Antimicrobial Peptides and Activities
- Urinary Bladder and Prostate Research
- Bacterial biofilms and quorum sensing
- Anesthesia and Sedative Agents
- Fungal Biology and Applications
- Acute Kidney Injury Research
- Dermatology and Skin Diseases
- Fungal and yeast genetics research
- Vitamin C and Antioxidants Research
- CRISPR and Genetic Engineering
- Radiation Dose and Imaging
- Vitamin K Research Studies
- Antimicrobial Resistance in Staphylococcus
- Biosensors and Analytical Detection
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Pelvic floor disorders treatments
- Gut microbiota and health
- COVID-19 and healthcare impacts
- Advanced MRI Techniques and Applications
Zunyi Medical University
2025
Peking University First Hospital
2021-2025
Peking University
2021-2025
National Clinical Research Center for Digestive Diseases
2025
Children's Hospital of Fudan University
2025
Shantou University
2024
Chinese Academy of Sciences
2017-2023
Institut Pasteur of Shanghai
2017-2023
University of Chinese Academy of Sciences
2022-2023
Yuhuangding Hospital
2022
Abstract Candida auris is a multidrug-resistant human fungal pathogen responsible for nosocomial outbreaks worldwide. Although considerable progress has increased our understanding of the biological and clinical aspects C. , its interaction with host immune system only now beginning to be investigated in-depth. Here, we compare innate responses induced by BJCA001 albicans SC5314 in vitro vivo. Our results indicate that appears less immunoinflammatory than SC5314, this differential response...
ABSTRACT Background Microsporum canis , a dermatophyte commonly associated with pets, is leading cause of severe tinea capitis. The increasing prevalence antifungal resistance among dermatophytes poses significant global health challenge. Objectives This study aims to define the updated susceptibility profile M. enhance treatment strategies for infections. Methods analysed 348 isolates from mainland China their 11 agents, following CLSI M38‐A3 guidelines. Additionally, we investigated agents...
Background: The medial prefrontal cortex plays a crucial role in regulating consciousness. However, the specific functions of its excitatory and inhibitory networks during anesthesia remain uncertain. Here we explored hypothesis that somatostatin interneurons enhance effects sevoflurane by increasing GABA transmission to pyramidal neurons. Methods: EEG was utilized reflect depth anesthesia. Immunostaining fiber photometry were employed assess neuronal activities delivery. regulation activity...
Tinea capitis is still common in developing countries, such as China. Its pathogen spectrum varies across regions and changes over time.This study aimed to clarify the current epidemiological characteristics of tinea China.A multicentre, prospective descriptive involving 29 tertiary hospitals China was conducted. From August 2019 July 2020, 611 patients with were enrolled. Data concerning demography, risk factors fungal tests collected. When necessary, pathogens further identified by...
Efficient assimilation of alternative carbon sources in glucose-limited host niches is critical for colonization Candida albicans, a commensal yeast that frequently causes opportunistic infection human. C. albicans evolved mechanistically to regulate the promotion fungal growth and commensalism mammalian hosts. However, this highly adaptive mechanism employs cope with has yet be clearly understood. Here we identified novel role mitochondrial complex I (CI) regulating such as mannitol. Our...
Successful host colonization by fungi in fluctuating niches requires response and adaptation to multiple environmental stresses. However, our understanding about how fungal species thrive the gastrointestinal (GI) ecosystem combing multifaceted nutritional stress with respect homeostatic host-commensal interactions is still its infancy. Here, we discover that depletion of phosphate transceptor Pho84 across encountered a substantial cost colonization. Mechanistically, enhances commensalism...
This work was to investigate the drug resistance, molecular and virulence characteristics of methicillin-resistant Staphylococcus aureus (MRSA) in burn patients provide empiric antibiotic therapy for clinical treatment. A total 365 non duplicate strains, including 85 MRSA 280 methicillin-susceptible (MSSA), were collected from 2008 2015. The susceptibility tests antibacterial agents performed by Kirby-Bauer disk diffusion method. Polymerase chain reaction (PCR) gel electrophoresis...
The transition metal iron plays a crucial role in living cells. However, high levels of are potentially toxic through the production reactive oxygen species (ROS), serving as deterrent to commensal fungus Candida albicans for colonization iron-rich gastrointestinal tract. We observe that mutant lacking an iron-responsive transcription factor Hap43 is hyper-fit murine gut. demonstrate specifically triggers multiple post-translational modifications and proteasomal degradation Hap43, vital...
Kerion is a severe type of tinea capitis that difficult to treat and remains public health problem.
Acute kidney injury (AKI) is a prevalent complication of coronavirus disease 2019 (COVID-19) and closely linked with poorer prognosis. The aim this study was to develop validate an easy-to-use accurate early prediction model for AKI in hospitalized COVID-19 patients.Data from 480 COVID-19-positive patients (336 the training set 144 validation set) were obtained public database Cancer Imaging Archive (TCIA). least absolute shrinkage selection operator (LASSO) regression method multivariate...
MicroRNA (miRNA) is a promising biomarker for early diagnosis of pancreatic cancer. To enable sensitive and reliable miRNA detection, we have developed one-pot isothermal CRISPR/Dx detection system by combining...
Abstract The transition metal iron plays a crucial role in living cells. However, high level of is potentially toxic through the production reactive oxygen species (ROS), serving as deterrent to commensal fungus Candida albicans for colonization iron-rich gastrointestinal (GI) tract. We observe that mutant lacking an iron-responsive transcription factor Hap43 hyper-fit murine gut. demonstrate specifically triggers multiple post-translational modifications (PTMs) and proteasomal degradation...
Objective To explore the appropriate traction weight of method for prevention leakage urine in elderly patients with indwelling urethral catheterization so as to provide a theoretical basis clinical work. Methods A total 120 department geriatrics Jiangdu People's Hospital Yangzhou (affiliated School Medicine, University) were selected by convenient sampling from January 2014 August 2016. They randomly divided into four groups and accepted involving 50, 100, 150, 200 g. The preventive...
Abstract This study aimed to compare MRI quality between common fast spin echo T 2 weighted imaging (FSE WI) with periodically rotated overlapping parallel lines enhanced reconstruction (PROPELLER) FSE WI for patients various porcelain fused metal (PFM) crown and analyze the value of PROPELLER technique in reducing artifacts. Common sequences axial head were applied participants different PFM crowns: cobalt-chromium (Co-Cr) alloy, pure titanium (Ti), gold-palladium (Au-Pd) alloy. Two...