A5101995423- Pancreatitis Pathology and Treatment
- Cancer-related molecular mechanisms research
- Antifungal resistance and susceptibility
- Pancreatic and Hepatic Oncology Research
- Dermatologic Treatments and Research
- Wound Healing and Treatments
- Mesenchymal stem cell research
- Computational Drug Discovery Methods
- RNA modifications and cancer
- Nanoplatforms for cancer theranostics
- Protease and Inhibitor Mechanisms
- Advanced Nanomaterials in Catalysis
- Corneal Surgery and Treatments
- Photoacoustic and Ultrasonic Imaging
- SARS-CoV-2 and COVID-19 Research
- ATP Synthase and ATPases Research
- Facial Rejuvenation and Surgery Techniques
- Tissue Engineering and Regenerative Medicine
- Hip and Femur Fractures
- Microbial Natural Products and Biosynthesis
- Bioactive Compounds and Antitumor Agents
- Synthesis and Biological Evaluation
- Laser Applications in Dentistry and Medicine
- Erythrocyte Function and Pathophysiology
- Vaccine Coverage and Hesitancy
Tongren Hospital
2019-2025
Shanghai Jiao Tong University
2015-2024
Shanghai Ninth People's Hospital
2017-2024
The University of Texas Medical Branch at Galveston
2012-2024
Shanghai Tenth People's Hospital
2020-2023
Tongji University
2020-2023
State Key Laboratory of Oncogene and Related Genes
2021-2022
Shanghai Sixth People's Hospital
2017-2019
Berufsgenossenschaftliche Unfallklinik Murnau
2017
Ruijin Hospital
2016
Severe acute pancreatitis (SAP), a life-threatening inflammatory disease of the pancreas, has high mortality rate (∼40 %). Current therapeutic approaches, including antibiotics, trypsin inhibitors, fasting, rehydration, and even continuous renal replacement therapy, yield limited clinical management efficacy. Abnormally elevated calcium levels reactive oxygen species (ROS) overproduction by damaged mitochondria are key factors in cascade SAP. The combination chelators cerium-based nanozymes...
Interaction of charge-switchable and multistage pH-responsive nanocapsules with MGC-803 cells at tumor site.
Recent anatomic findings suggest aging-related changes of the complex fat distribution in hand. To rejuvenate aging hand, we developed a targeted grafting technique based on physiologic The dorsum both hands was examined 30 healthy volunteers different age utilizing B-mode ultrasound to determine physiological Additional dissection performed 10 five fresh cadavers establish basis for restoration technique. A total 17 patients were treated hand rejuvenation this and followed up at least 6...
Abstract Background Patients with severe acute pancreatitis (SAP), which is characterized by high morbidity and mortality, account for an increasing medical burden worldwide. We previously found that mesenchymal stem cells (MSCs) could attenuate SAP expression of long noncoding RNA H19 (LncRNA H19) was upregulated in rats receiving MSCs. In the present study, we investigated mechanisms LncRNA regulating therapeutic efficacy MSCs alleviation SAP. Methods transfected overexpression knockdown...
Active drug-loaded nanocarriers have been widely employed as efficient drug delivery systems for tumor theranostics. Herein, we report folate-mediated "all-in-one" nanobubbles tumor-targeted NIR/MR/US imaging and combined chemo-photothermal therapy. The surface-engineered are constructed from oleylamine-/IR-780-loaded hollow structures, folate the GdDTPA-BSA@5-FU complex via electrostatic adsorption further filled with gas after freeze drying. DLS data show that a hydrodynamic diameter of...
PAMs new in town! An effective, combined bioinformatics and chemoinformatics approach was applied to the design of novel asymmetric bivalent α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor positive allosteric modulators (PAMs) with marked potency vitro efficacy vivo for preventing neuroapoptosis. The chemotype could provide pharmacological probes potential therapeutic agents glutamatergic hypofunction its related neurological psychiatric disorders. As a service our...
Abstract Pancreatic ductal adenocarcinoma (PDAC) is one of the leading causes cancer death. Early detection precancerous pancreatic intraepithelial neoplasia (PanIN) tissues an urgent challenge to improve PDAC prognosis. Here, a urokinase‐type plasminogen activator receptor (uPAR)‐targeted magnetic resonance (MR)/near‐infrared fluorescence (NIRF) dual‐modal nanoprobe dendron‐grafted polylysine (DGL)‐U11 for ultra‐early precancerosis reported. Because its good biocompatibility and...
Background: Cartilage tissue engineering provided a promising therapy for the repair of cartilage defects, and seeding cells play vital role in regeneration. Chondrocytes bone marrow-derived mesenchymal stem (BMSCs) were reported to be ideal cells, but ‘dedifferentiation’ ‘unstable phenotype’ tissue-engineered constructed by two cell type hamper their clinical application. Recently, was possess population, which may more superior source engineering.
Abstract Background Pancreatic cancer (PC) is an aggressive malignancy with poor prognosis. Accumulating studies have showed that long non‐coding RNA (lncRNA) a crucial regulator in various tumorigenesis and progression including PC. This research aims to explore the roles molecular mechanism of lncRNA susceptibility candidate 9 (CASC9) Methods The expression levels CASC9 miR‐497‐5p were evaluated PC tissues paired adjacent healthy by quantitative real‐time PCR. cell lines transfected...
Successful host colonization by fungi in fluctuating niches requires response and adaptation to multiple environmental stresses. However, our understanding about how fungal species thrive the gastrointestinal (GI) ecosystem combing multifaceted nutritional stress with respect homeostatic host-commensal interactions is still its infancy. Here, we discover that depletion of phosphate transceptor Pho84 across encountered a substantial cost colonization. Mechanistically, enhances commensalism...
Background and Purpose: Remote white matter cortex reorganization may contribute to functional clinical outcome after acute infarcts. To determine the microstructural changes in remote intact corticospinal tract (CST) precentral gyrus connected infarct subcortical stroke involving CST over 6 months. Methods: Twenty-two patients with underwent magnetic resonance imaging (MRI) assessment phase (baseline) months (follow-up) stroke. The MRI sequences included T1-weighted imaging, T2-weighted...
Fungal infections have emerged as a major global threat to human health because of the increasing incidence and mortality rates every year. The emergence drug resistance limited arsenal antifungal agents further aggravates current situation resulting in growing challenge medical mycology. Here, we identified that ponatinib, an FDA-approved antitumour drug, significantly enhanced activity azole fluconazole, most widely used drug. Further detailed investigation ponatinib revealed its...
Background:Diabetic retinopathy (DR) is a progressive neurodegenerative disease with early-stage symptoms such as dysfunction of Muller cells, which leads to ganglion cell death.Its pathogenesis probably associated oxidative stress and recently discovered protein, thioredoxin-interacting protein (TXNIP). Material/Methods:To explore the role TXNIP in DR, we cultured cells under diabetic conditions, then used immunohistochemistry, Western blot, RT-PCR detect expression level conditions.We...
Abstract Background Salvia miltiorrhiza (SM) is an herb used in Chinese medicine formulations for promoting blood circulation and minimizing vascular stasis. It has been successfully utilized treating cardiovascular diseases, such as atherosclerosis, thromboembolism, angina. Objectives The authors sought to study the effect of SM injections autologous fat grafting breast. Methods Fifteen women who elected undergo breast augmentation with were included this study. Of these, 10 given...
Hypertrophic scar (HTS) formation is a pathological fibrotic skin disease, with no satisfactory treatments available currently. Inducing apoptosis of HTS-derived fibroblasts (HSFs) are becoming promising approaches. In this research, we aim to improve the technology co-delivery COX-2 and TGF-β1 siRNAs further investigate underlying mechanism. Firstly, HSFs were transfected 1 µg/ml and/or siRNAs, proved that was greater induced by COX-2/TGF-β1 than either or siRNA alone flow cytometry. To...
Keloids are scars characterized by abnormal proliferation of fibroblasts and overproduction extracellular matrix components including collagen. We previously showed that LY2109761, a transforming growth factor- (TGF-) β receptor inhibitor, suppressed the secretion slowed derived from human hypertrophic scar tissue. However, exact mechanism underlying this effect remains unclear. Here, we replicated above results in keloid-derived show LY2109761 promoted apoptosis, decreased phosphorylation...
Skin fibrotic diseases are characterized by abnormal fibroblast function and excessive deposition of extracellular matrix. Our previous single-cell sequencing results identified an enriched subcluster in skin tissues that highly expresses the actin cross-linking cytoskeletal protein Transgelin (TAGLN), which bridges mechanical environment cellular metabolism. Therefore, we aimed to investigate role TAGLN pathogenesis fibrosis. Transwell, wound healing, collagen gel contraction assay,...