A5101674051- Nanoplatforms for cancer theranostics
- Nanoparticle-Based Drug Delivery
- Advanced Nanomaterials in Catalysis
- Luminescence and Fluorescent Materials
- RNA Interference and Gene Delivery
- Photoacoustic and Ultrasonic Imaging
- Advanced biosensing and bioanalysis techniques
- Protease and Inhibitor Mechanisms
- Extracellular vesicles in disease
- Cancer Cells and Metastasis
- Soft Robotics and Applications
- Advanced Photocatalysis Techniques
- Tissue Engineering and Regenerative Medicine
- Pancreatic and Hepatic Oncology Research
- Gallbladder and Bile Duct Disorders
- Graphene and Nanomaterials Applications
- Dendrimers and Hyperbranched Polymers
- Supramolecular Self-Assembly in Materials
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Neuroinflammation and Neurodegeneration Mechanisms
- Liver Disease Diagnosis and Treatment
- Fetal and Pediatric Neurological Disorders
- Electrospun Nanofibers in Biomedical Applications
- Cancer Research and Treatments
- Pregnancy and Medication Impact
Shanghai Sixth People's Hospital
2015-2025
Shanghai Jiao Tong University
2014-2025
Tongji Hospital
2024
Shanghai Cancer Institute
2012
Shanghai Tenth People's Hospital
2012
Renji Hospital
2012
Light in the second near-infrared window, especially beyond 1500 nm, shows enhanced tissue transparency for high-resolution vivo optical bioimaging due to decreased scattering, absorption, and autofluorescence. Despite some inorganic luminescent nanoparticles have been developed improve around it is still a great challenge synthesize organic molecules with absorption emission toward this region. Here, we present J-aggregates 1360 nm 1370 formed by self-assembly of amphiphilic cyanine dye...
Real-time monitoring of vessel dysfunction is great significance in preclinical research. Optical bioimaging the second near-infrared (NIR-II) window provides advantages including high resolution and fast feedback. However, reported molecular dyes are hampered by limited blood circulation time (~ 5-60 min) short absorption emission wavelength, which impede accurate long-term monitoring. Here, we report a NIR-II molecule (LZ-1105) with beyond 1000 nm. Thanks to long (half-life 3.2 h),...
Oxidative stress and a series of excessive inflammatory responses are major obstacles for neurological functional recovery after ischemic stroke. Effective noninvasive anti-inflammatory therapies urgently needed. However, unsatisfactory therapeutic efficacy current drugs inadequate drug delivery to the damaged brain problems. Nanozymes with robust antioxidative properties possess possibility insufficiency nanozyme accumulation in by administration hindered their application. Herein, we...
The clinical treatment efficacy for implant-associated infections (IAIs), particularly those caused by Methicillin-resistant Staphylococcus aureus (MRSA), remains unsatisfactory, primarily due to the formation of biofilm barriers and resulting immunosuppressive microenvironment, leading chronicity recurrence IAIs. To address this challenge, we propose a light-induced immune enhancement strategy, synthesizing BSA@MnO2@Ce6@Van (BMCV). BMCV exhibits precise targeting adhesion S....
Abstract Background Chemotherapy and gene therapy are used in clinical practice for the treatment of castration-resistant prostate cancer. However, poor efficiency drug delivery serious systemic side effects remain an obstacle to wider application these drugs. Herein, we report newly designed PEO-PCL micelles that were self-assembled modified by spermine ligand, DCL ligand TAT peptide carry docetaxel anti-nucleostemin siRNA. Results The particle size was 42 nm, zeta potential increased from...
Cardiovascular and cerebrovascular diseases induced by atherosclerosis (AS) have become the dominant cause of disability mortality throughout world. The typical early pathological process AS involves activation inflammatory macrophages in vulnerable plaque. In this work, we first employed chitosan-coated carbon nanocages (CS-CNCs) as nanocarriers to load Chlorin e6 (Ce6) then linked dextran sulfate (DS) outermost layer electrostatic adsorption create a multifunctional therapeutic...
The BSA-MnO<sub>2</sub>/IR820@OCNC nanosystem is a “one for all” system that allows highly efficacious real-time imaging-guided phototherapy of esophageal cancer.
Gallstone disease (GSD) is a common and costly health issue with multifactorial etiology linked to obesity. The Weight-Adjusted-Waist Index (WWI) novel anthropometric measure that incorporates both weight waist circumference, potentially offering better assessment of GSD risk associated adiposity. This study aims evaluate the association between WWI prevalence GSD. We conducted cross-sectional involving 19,426 participants divided into stone (n = 4,398) non-stone 15,028) groups based on...
Interaction of charge-switchable and multistage pH-responsive nanocapsules with MGC-803 cells at tumor site.
A smart nanotheranostics nanoplatform was constructed using engineered graphene oxide and the in situ growth of ultrasmall superparamagnetic iron particles (SPIONs). The construction such a novel theranostics shows great potential tumor theranostics, especially for T1-weighted magnetic resonance (T1-MR) imaging guided, pH-sensitive chemotherapy.
The inflammatory activity of ulcerative colitis plays an important role in the medical treatment. However, accurate and real-time monitoring with noninvasive bioimaging method is still challenging, especially distinguishing between chronic acute colitis. As a good receptor, oligopeptide transporter (PepT1) overexpressed colonic epithelial cells colitis, which can deliver tripeptide KPV (Lys-Pro-Val, C-terminal sequence α-MSH) into cytosol intestine. Herein, we report PepT1 peptide...
Pancreatic ductal adenocarcinoma (PDAC), as one of the most malignant tumors with dense desmoplastic stroma, forms a specific matrix barrier to hinder effective diagnosis and therapy. To date, paramount challenge is in search for intelligent nanotheranostics such hypopermeable tumors, especially breaking PDAC-specific physical barrier. The unpredictable vivo behaviors nanotheranostics, that is, real-time tracking where, when, how they cross barriers are taken up by tumor cells, major...
The monitoring of pancreatic ductal adenocarcinoma (PDAC) in high-risk populations is essential. Cathepsin E (CTSE) specifically and highly expressed PDAC intraepithelial neoplasias (PanINs), its expression gradually increases along with disease progression. In this study, we first established an situ 7,12-dimethyl-1,2-benzanthracene (DMBA)-induced rat model for PanINs then confirmed that tumorigenesis properties were consistent those human CTSE increased tumor development using histology...
Abstract Pancreatic ductal adenocarcinoma (PDAC) is one of the leading causes cancer death. Early detection precancerous pancreatic intraepithelial neoplasia (PanIN) tissues an urgent challenge to improve PDAC prognosis. Here, a urokinase‐type plasminogen activator receptor (uPAR)‐targeted magnetic resonance (MR)/near‐infrared fluorescence (NIRF) dual‐modal nanoprobe dendron‐grafted polylysine (DGL)‐U11 for ultra‐early precancerosis reported. Because its good biocompatibility and...
Abstract Poly(ethylene glycol) grafted octadecyl quaternized carboxymethyl chitosan (PEG‐ g ‐OQC) copolymers were synthesized to both improve the biocompatibility of OQC and form PEGylated cationic polymeric liposomes (CPLs), which composed mixture OQC, cholesterol, PEG‐ ‐OQC. Structure was characterized by using Fourier transform infrared spectroscopy (FTIR), proton nuclear magnetic resonance ( 1 H‐NMR), X‐ray diffraction (XRD). The methyl tetrazolium (MTT) assay with L929 cell lines...
Ultrasound-guided percutaneous needle insertion is a standard procedure employed in both biopsy and ablation clinical practices. However, due to the complex interaction between tissue instrument, may deviate from in-plane view, resulting lack of close monitoring needle. To address this challenge, we introduce robot-assisted ultrasound (US) imaging system designed seamlessly monitor process autonomously restore visibility inserted instrument when misalignment happens. end, adversarial...
Background: Albumin-bound paclitaxel (nab-PTX) nanoparticles have been proven effective in treating advanced pancreatic cancer. However, the clinical application of nab-PTX is often associated with suboptimal outcomes and severe side effects due to its non-specific distribution rapid clearance. This study aims develop a novel nanoplatform that integrates sonodynamic therapy (SDT) chemotherapy enhance treatment efficacy reduce systemic effects. Methods: Bovine serum albumin (BSA) was...
Abstract Magnetic resonance imaging (MRI) contrast agents are broadly employed for better clinical trials in MR imaging. Magnevist solution (Gd‐DTPA), a MRI agent, possesses inherent shortcomings like poor r 1 relaxation, short half‐time, nephrotoxicity, etc. To overcome these problems, Gd‐DTPA‐grafted protein assemblies (Gd‐P‐ABs) loading with anticancer drug cisplatin and photosentizer IR‐780 constructed via chelation of Gd 3+ . Gd‐P‐ABs exhibit dual MR/fluorescence (FL) imaging–guided...