A5024426748- Nanoparticle-Based Drug Delivery
- Silicon Nanostructures and Photoluminescence
- Advanced Drug Delivery Systems
- Drug Solubulity and Delivery Systems
- Nanoplatforms for cancer theranostics
- Graphene and Nanomaterials Applications
- Advancements in Transdermal Drug Delivery
- RNA Interference and Gene Delivery
- Nanowire Synthesis and Applications
- Advanced biosensing and bioanalysis techniques
- Microfluidic and Capillary Electrophoresis Applications
- Crystallization and Solubility Studies
- Mesoporous Materials and Catalysis
- Electrospun Nanofibers in Biomedical Applications
- 3D Printing in Biomedical Research
- Pharmaceutical Practices and Patient Outcomes
- Innovative Microfluidic and Catalytic Techniques Innovation
- Protein purification and stability
- Carbon and Quantum Dots Applications
- Lipid Membrane Structure and Behavior
- Analytical Chemistry and Chromatography
- Pharmacogenetics and Drug Metabolism
- Tissue Engineering and Regenerative Medicine
- Immunotherapy and Immune Responses
- Drug Transport and Resistance Mechanisms
University of Helsinki
2016-2025
Kuopio University Hospital
2018-2020
International Drug Development
2016-2020
Pharmaceutical Biotechnology (Czechia)
2018-2020
Seinäjoki University of Applied Sciences
2020
Helsinki Art Museum
2015
University of Turku
2007-2012
Swedish Chemicals Agency
2010
Åbo Akademi University
2007
University of Eastern Finland
1991-2000
Porous silicon (PSi) particles have been studied for the effects they elicit in Caco-2 and RAW 264.7 macrophage cells terms of toxicity, oxidative stress, inflammatory response. The most suitable were then functionalized with a novel 18F label to assess their biodistribution after enteral parenteral administration rat model. results show that thermally hydrocarbonized porous (THCPSi) nanoparticles did not induce any significant or response cells. Fluorescently labeled associated surface but...
Abstract Generation of reactive oxygen species, delayed blood clotting, prolonged inflammation, bacterial infection, and slow cell proliferation are the main challenges effective wound repair. Herein, a multifunctional extracellular matrix‐mimicking hydrogel is fabricated through abundant hydrogen bonding among functional groups gelatin tannic acid (TA) as green chemistry approach. The shows adjustable physicochemical properties by altering concentration TA it represents high safety features...
Immunoadjuvant porous silicon (PSi)-based nanovaccines are prepared by nanoprecipitation in a glass capillary microfluidics device. Vesicles, derived from cancer cell membranes encapsulating thermally oxidized PSi nanoparticles or PSi-polymer nanosystems binding model antigen, biocompatible over wide range of concentrations, and show immunostimulant properties human cells, promoting the expression co-stimulatory signals secretion pro-inflammatory cytokines. As service to our authors readers,...
Abstract Drug delivery systems with high content of drug can minimize excipients administration, reduce side effects, improve therapeutic efficacy and/or promote patient compliance. However, engineering such is extremely challenging, as their loading capacity inherently limited by the compatibility between molecules and carrier materials. To mitigate drug-carrier limitation towards therapeutics encapsulation, we developed a sequential solidification strategy. In this strategy, precisely...
As a result of the deficient tumor-specific antigens, potential off-target effect, and influence protein corona, metal-organic framework nanoparticles have inadequate accumulation in tumor tissues, limiting their therapeutic effects. In this work, pH-responsive linker (L) is prepared by covalently modifying oleylamine (OA) with 3-(bromomethyl)-4-methyl-2,5-furandione (MMfu) poly(ethylene glycol) (PEG). Then, L embedded into solid lipid nanoshell to coat apilimod (Ap)-loaded zeolitic...
The feasibility of four mesoporous materials composed biocompatible Si (TCPSi) or SiO2 (MCM-41, SBA-15, and TUD-1) were evaluated for oral drug delivery applications. main focus was to study the effect different pore systems (unidirectional/2D/3D) their diameters, size distributions, volumes on maximal load capacity, release profiles a loaded active pharmaceutical ingredient. Ibuprofen used as model drug. total volume solid factor limiting maximum with SBA-15 reaching very high 1:1 in weight...