A5039983100- Nanoparticle-Based Drug Delivery
- Advanced Drug Delivery Systems
- RNA Interference and Gene Delivery
- Hydrogels: synthesis, properties, applications
- Lipid Membrane Structure and Behavior
- Graphene and Nanomaterials Applications
- Erythrocyte Function and Pathophysiology
- Analytical Methods in Pharmaceuticals
- Drug Solubulity and Delivery Systems
- Nanoplatforms for cancer theranostics
- Advanced Polymer Synthesis and Characterization
- Antibiotics Pharmacokinetics and Efficacy
- biodegradable polymer synthesis and properties
- HIV/AIDS drug development and treatment
- Blood properties and coagulation
- Advancements in Transdermal Drug Delivery
- Mesoporous Materials and Catalysis
- Drug Transport and Resistance Mechanisms
- Analytical Chemistry and Chromatography
- Curcumin's Biomedical Applications
- Advanced biosensing and bioanalysis techniques
- HIV Research and Treatment
- Lipoproteins and Cardiovascular Health
- Pancreatic function and diabetes
- Computational Drug Discovery Methods
Zanjan University of Medical Sciences
2016-2025
University of Zanjan
2016-2023
Chemotherapy Foundation
2017
Weatherford College
2008-2014
Shiraz University of Medical Sciences
2004-2013
University of Helsinki
2012
Laboratoire de Chimie Physique
2011
Université Moulay Ismail de Meknes
2007
University of Toronto
2002-2003
Tehran University of Medical Sciences
2000-2001
Because of expanding presence nanomaterials, there has been an increase in the exposure humans to nanoparticles that is why nanotoxicology studies are important. A number on effects nanomatrials vitro and vivo systems have published. Currently cytotoxicity different assessed using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay cell lines determine viability, a tedious expensive method. The aim this study was evaluate Artemia salina test comparison with MTT...
Curcumin is a multitherapeutic agent with great therapeutic potential in central nervous system (CNS) diseases. In the current study, curcumin was encapsulated solid lipid nanoparticles (SLNs) and nanostructured carriers (NLCs) for purpose of increasing brain accumulation. The preparation processes have been optimized using experimental design multiobjective optimization methods. Entrapment efficiency SLNs NLCs found to be 82% ± 0.49 94% 0.74, respectively. pharmacokinetic studies showed...
Superparamagnetic iron oxide nanoparticles (SPIONs) are the most commonly used negative MRI contrast agent which affect transverse (T2) relaxation time. The aim of present study was to investigate impact various polymeric coatings on performance magnetite as agents. Ferrofluids based (Fe3O4) were synthesized via chemical co-precipitation method and coated with different biocompatible polymer including mPEG-PCL, chitosan dextran. bonding status polymers surface confirmed by Fourier transform...
Repaglinide is an efficient anti-diabetic drug which prescribed widely as multi-dosage oral daily regimens. Due to the low compliance inherent each regimen, development of prolonged-release formulations could enhance overall efficacy in patient populations. Repaglinide-loaded solid lipid nanoparticles (SLNs) were developed and characterized vitro. Various surfactants used this study during nanocarrier preparation procedure their corresponding effects on some physicochemical properties SLNs...
A conjugate of the antihypertensive drug, lisinopril, with triblock poly(lactic acid)-poly(ethylene glycol)-poly(lactic acid) (PLA-PEG-PLA) copolymer was synthesized by reaction PLA-PEG-PLA lisinopril in presence dicyclohexylcarbodiimide and dimethylaminopyridine. The conjugated characterized vitro hydrogen nuclear magnetic resonance (HNMR), Fourier transform infrared (FTIR), differential scanning calorimetry (DSC) gel permeation chromatography (GPC) techniques. Then, were self-assembled...
Alzheimer's disease (AD) is one of the most common neurodegenerative diseases and caused by accumulation amyloid-β (Aβ) peptide associated with neurological abnormalities in learning memory. The protective role curcumin on nerve cells, along a potent antioxidant free r adical scavenging activity, has been widely studied. However, its low bioavailability limited transport ability across blood-brain barrier are two major drawbacks application treatment different diseases. present study was...
The blood–brain barrier (BBB) acts as a physical/biochemical that protects brain parenchyma from potential hazards exerted by different xenobiotics found in the systemic circulation. This is created "a lipophilic gate" well series of highly organized influx/efflux mechanisms. BBB bottleneck adversely affects efficacy chemotherapeutic agents treating CNS malignancies such glioblastoma, an aggressive type cancer affecting brain. In present study, mesoporous silica nanoparticles (MSNs) were...
The purpose of this study was to prepare nanoparticles made tri-block poly(lactide)–poly(ethylene glycol)–poly (lactide) (PLA–PEG–PLA) with controlled size as drug carrier. Artificial neural networks (ANNs) were used identify factors which influence particle size. In way, PLA–PEG–PLA synthesized and into by nanoprecipitation under different conditions. copolymer the resulting characterized various techniques such proton nuclear magnetic resonance spectroscopy, Fourier transform infrared gel...
Among the potent anticancer agents, curcumin is known as a very efficacious against many different types of cancer cells, but its clinical applications has been limited because hydrophobicity, low gastrointestinal absorption, poor bioavailability and rapid metabolism. In this way, novel micellar delivery system with mPEG-PCL was synthesized release profile from drug-loaded micelles evaluated.In study, encapsulated within monomethoxypoly(ethylene glycol)-poly(ε-caprolactone) (mPEG-PCL)...
Introduction: Expansion of efficacious theranostic systems is pivotal significance for medicine and human healthcare. Magnetic nanoparticles (MNPs) are known as drug delivery system magnetic resonance imaging (MRI) contrast agent. MNPs carriers have attracted significant attention because the drugs loaded onto to solid tumors, maintaining them in target site by an external electromagnetic field, subsequently releasing a controlled manner. On other hand, it believed that possess high...