A5072347904- Advanced Drug Delivery Systems
- Nanoparticle-Based Drug Delivery
- Advancements in Transdermal Drug Delivery
- RNA Interference and Gene Delivery
- Lipid Membrane Structure and Behavior
- Glioma Diagnosis and Treatment
- Alzheimer's disease research and treatments
- Hydrogels: synthesis, properties, applications
- Drug Solubulity and Delivery Systems
- Acute Lymphoblastic Leukemia research
- Graphene and Nanomaterials Applications
- Nanoplatforms for cancer theranostics
- CNS Lymphoma Diagnosis and Treatment
- Dermatology and Skin Diseases
- Cancer Treatment and Pharmacology
- Essential Oils and Antimicrobial Activity
- Lymphoma Diagnosis and Treatment
- Neurological Disorders and Treatments
- Brain Metastases and Treatment
- Antibiotics Pharmacokinetics and Efficacy
- Protein Kinase Regulation and GTPase Signaling
- Olfactory and Sensory Function Studies
- Tryptophan and brain disorders
- Pharmacological Effects of Natural Compounds
- Chronic Lymphocytic Leukemia Research
Shiraz University of Medical Sciences
2016-2025
Shiraz University
2022-2024
HonorHealth
2022-2023
Flagstaff Medical Center
2022
Barrow Neurological Institute
2020-2022
The University of Texas MD Anderson Cancer Center
2022
Banner MD Anderson Cancer Center
2022
Finnish Society of Sciences and Letters
2022
University of Helsinki
2022
Nutrition 21 (United States)
2022
Poly (lactic-co-glycolic acid) has received much academic attention for developing nanotherapeutics and FDA approved it several applications. An important parameter that dictates the bioavailability hence biological effect of drug is release from its delivering system. This study offers a comparative mathematical analysis acid)-based nanoparticles to suggest general model explaining multi-mechanistic they provide.Eight models, zero order, first Higuchi, Hixson-Crowell, square root mass,...
Curcumin is a multitherapeutic agent with great therapeutic potential in central nervous system (CNS) diseases. In the current study, curcumin was encapsulated solid lipid nanoparticles (SLNs) and nanostructured carriers (NLCs) for purpose of increasing brain accumulation. The preparation processes have been optimized using experimental design multiobjective optimization methods. Entrapment efficiency SLNs NLCs found to be 82% ± 0.49 94% 0.74, respectively. pharmacokinetic studies showed...
Alzheimer's disease (AD) is one of the most common neurodegenerative diseases and caused by accumulation amyloid-β (Aβ) peptide associated with neurological abnormalities in learning memory. The protective role curcumin on nerve cells, along a potent antioxidant free r adical scavenging activity, has been widely studied. However, its low bioavailability limited transport ability across blood-brain barrier are two major drawbacks application treatment different diseases. present study was...
The blood–brain barrier (BBB) acts as a physical/biochemical that protects brain parenchyma from potential hazards exerted by different xenobiotics found in the systemic circulation. This is created "a lipophilic gate" well series of highly organized influx/efflux mechanisms. BBB bottleneck adversely affects efficacy chemotherapeutic agents treating CNS malignancies such glioblastoma, an aggressive type cancer affecting brain. In present study, mesoporous silica nanoparticles (MSNs) were...
The development of remineralizing smart biomaterials is a contemporary approach to caries prevention. present study aimed at formulation preparation and characterization thermoresponsive oral gel based on poloxamer chitosan loaded with sodium fluoride (NaF) nanohydroxyapatite (nHA) treat demineralization. chemical structure morphology the were characterized using FTIR FESEM-EDS tests. Hydrogel texture, rheology, stability also examined. hydrogel was in sol state room temperature became after...
Cyproterone acetate (CPA) is used to treat various skin disorders such as acne, hirsutism, and alopecia. Due the limited penetration of CPA, nanostructured lipid carriers (NLCs) with different size ranges were considered in this study order enhance target hair follicles. Drug loading, drug release morphological assessment evaluated for each targeted (100, 300, 600 nm). Ex vivo was also investigated using Franz diffusion cells. Finally, follicular targeting rhodamine B-loaded micro...
In-Vitro Dissolution Study and Shelf Life Calculation of Developed Sol-To-Gel Ocular Drug Delivery System Brimonidine for Conjunctivitis during Accelerated Stability StudyManu Babbar, Kanchan Kohli, Anil Bhandari
Alzheimer's disease (AD) is a neurodegenerative that associated with neuroinflammation. Dextromethorphan (DXM) exerts neuroprotective effects in many central nervous system injuries and diseases. The cell wall of Saccharomyces cerevisiae cell-based drug delivery can be suitable candidate for targeted to the site inflammation. In this study, nanoparticles (NPs) were prepared from walls, coated polysorbate-80, loaded DXM. NPs had favorable hemolytic behavior particle size distribution 187.25 ±...