A5015899892- Synthesis and biological activity
- Synthesis and Characterization of Heterocyclic Compounds
- Nanoparticle-Based Drug Delivery
- Advanced Drug Delivery Systems
- RNA Interference and Gene Delivery
- Synthesis and Biological Evaluation
- Inflammatory mediators and NSAID effects
- Synthesis and Reactions of Organic Compounds
- Click Chemistry and Applications
- Computational Drug Discovery Methods
- Phytochemistry and Biological Activities
- Steroid Chemistry and Biochemistry
- Synthesis of heterocyclic compounds
- Phenothiazines and Benzothiazines Synthesis and Activities
- Pharmacogenetics and Drug Metabolism
- Advanced biosensing and bioanalysis techniques
- Essential Oils and Antimicrobial Activity
- Analytical Chemistry and Chromatography
- Synthesis of β-Lactam Compounds
- Natural Antidiabetic Agents Studies
- Analytical Methods in Pharmaceuticals
- Quinazolinone synthesis and applications
- Antibiotics Pharmacokinetics and Efficacy
- Cancer therapeutics and mechanisms
- Cancer Treatment and Pharmacology
Tehran University of Medical Sciences
2016-2025
Development Research Center
2010-2025
University of Tehran
2007-2024
Food and Drug Administration
2019
Institute of Medicinal Plant Development
2017-2018
Isfahan University of Medical Sciences
2016
Pasteur Institute of Iran
2012
Shiraz University of Medical Sciences
2011
Biotechnology Research Center
2010
Pharmaceutical Biotechnology (Czechia)
2010
For folate-receptor-targeted anticancer therapy, docetaxel (DTX) nanoparticles (NPs) were produced employing polylactide-co-glycolide–polyethylene glycol–folate (PLGA–PEG–FOL) conjugate. The FOL-conjugated di-block copolymer was synthesized by coupling the PLGA–PEG–NH2 with an activated folic acid. It expected that FOL moieties exposed on micellar surface.The conjugates assisted in formation of DTX NPs average size 200 nm diameter through emulsification/solvent diffusion method. FOL-targeted...
The aim of this study was to develop and characterize 5-Fluorouracil (5FU) containing targeted liposomes in order enhance the efficacy safety drug. Folic acid (FA) used as a targeting ligand. vitro cytotoxicity formulation against HT-29, Caco-2, CT26, HeLa MCF-7 cell lines evaluated using MTT assay. Mechanism death induced by further investigated via production reactive oxygen species (ROS), change mitochondrial membrane potential (ΔΨm), release cytochrome c activity caspase 3/7. vivo tumor...
Context: Growth factors act in an integrated manner to promote the wound-healing process. However, probably due early inactivation of these molecules wound site, their topical administration scarcely leads a significant improvement chronic repair.Objectives: With aim identifying improved therapeutics, sodium carboxymethyl chitosan-recombinant human epidermal growth factor conjugate (NaCMCh-rhEGF) was developed. It is believed that conjugation will protect rhEGF against proteolysis and...
In the present survey, plasma level of diazinon after acute exposure was measured by HPLC method at a time-course manner. addition, impact on expression key genes responsible for hepatocellular antioxidative defense, including PON1, GPx and CAT were investigated. The increase in oxidative damages treated rats determined measuring LPO, protein carbonyl content total antioxidant power plasma. After administration 85 mg/kg ten groups male Wistar different time points between 0-24 hours,...
AbstractFischerella ambigua was isolated during a screening program from soil sample collected paddy-fields in the north of Iran. It shown that it excreted broad-spectrum antibacterial and antifungal substance culture medium. Bioassay-guided fraction medium F. led to isolation novel antimicrobial substance, which named parsiguine, exhibited activities. The structure parsiguine determined by spectroscopic methods, including NMR, MS, IR, UV.Keywords: : AntibioticAntimicrobial...
A group of 6-alkyl (alkoxy or alkylthio)-4-aryl-3-(4-methanesulfonylphenyl)pyran-2-ones (14a-v), possessing either a H F substituent at the para-position C-4 phenyl ring, were designed for evaluation as selective cyclooxygenase-2 (COX-2) inhibitors with in vivo antiinflammatory-analgesic activities. Although 6-ethylthio-3-(4-methanesulfonylphenyl)-4-phenylpyran-2-one (14s) exhibited very high vitro COX-2 inhibitory potency (IC(50) = 0.0032 muM) and selectivity (SI > 120 000), 14s moderate...