A5069744121- Nanoparticle-Based Drug Delivery
- Advanced Drug Delivery Systems
- Analytical chemistry methods development
- RNA Interference and Gene Delivery
- 3D Printing in Biomedical Research
- Bone Tissue Engineering Materials
- Advanced biosensing and bioanalysis techniques
- Forensic Toxicology and Drug Analysis
- Microfluidic and Capillary Electrophoresis Applications
- Advancements in Transdermal Drug Delivery
- Analytical Chemistry and Chromatography
- Electrospun Nanofibers in Biomedical Applications
- Protein Interaction Studies and Fluorescence Analysis
- Extracellular vesicles in disease
- Metal complexes synthesis and properties
- Analytical Chemistry and Sensors
- Caveolin-1 and cellular processes
- Dendrimers and Hyperbranched Polymers
- Essential Oils and Antimicrobial Activity
- Lanthanide and Transition Metal Complexes
- Drug Solubulity and Delivery Systems
- Immune cells in cancer
- Nanoplatforms for cancer theranostics
- Dermatologic Treatments and Research
- Luminescence and Fluorescent Materials
Tehran University of Medical Sciences
2015-2025
Development Agency of Serbia
2024
University of Tehran
2023
Harvard–MIT Division of Health Sciences and Technology
2022
Massachusetts Institute of Technology
2022
Innovation Research Center
2022
Brigham and Women's Hospital
2022
Harvard University
2022
Amirkabir University of Technology
2010-2016
Background: Low drug entrapment efficiency of hydrophilic drugs into poly(lactic-co-glycolic acid) (PLGA) nanoparticles is a major drawback. The objective this work was to investigate different methods producing PLGA containing minocycline, suitable for periodontal infections. Methods: Different methods, such as single and double solvent evaporation emulsion, ion pairing, nanoprecipitation were used prepare both PEGylated nanoparticles. resulting analyzed their morphology, particle size...
A folate-receptor-targeted poly (lactide-co-Glycolide) (PLGA)-Polyethylene glycol (PEG) nanoparticle is developed for encapsulation and delivery of disulfiram into breast cancer cells. After a comprehensive characterization nanoparticles, cell cytotoxicity, apoptosis induction, cellular uptake intracellular level reactive oxygen species are analyzed. In vivo acute chronic toxicity nanoparticles their efficacy on inhibition tumor growth studied. The internalized the cells, induce formation,...
Abstract This study focus on the effect of porogenic solvent morphology, recognition, and drug release carbamazepine‐molecularly imprinted polymer nanospheres prepared by precipitation polymerization. The scanning electron microscopy (SEM) images Brunauer‐Emmett‐Teller (BET) analysis showed that molecularly (MIP) acetonitrile exhibited a regular spherical shape at nanoscale with high degree monodispersity, specific surface area 242 m 2 g −1 , pore volume 1 mL while those using chloroform...
Nanoparticles (NPs) play an important role in anticancer delivery systems. Surface modified NPs with hydrophilic polymers such as human serum albumin (HSA) have long half-life the blood circulation system.The method of nanoprecipitation was utilized for encapsulation paclitaxel (PTX) poly (lactic-co-glycolic acid) (PLGA). Para-maleimide benzoic hydrazide conjugated to PLGA surface modifications NPs, and then HSA attached on prepared by maleimide attachment thiol groups (cysteines) albumin....
Glioblastoma multiforme (GBM) is a widespread and life-threatening kind of brain cancer, which has high mortality rate. Ibrutinib, Bruton's tyrosine kinase (BTK) inhibitor, irreversibly adheres to conserved cysteine residue two enzymes BTK BMX, inhibiting their activities leads suppression the growth glioma cells. This study synthesized PLGA-PEG-folate (PPF) polymer subsequently encapsulated ibrutinib within PPF nanoparticles (IBT-PPF-NPs). HNMR spectra confirmed synthesis polymer. The...