A5068673089- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- RNA modifications and cancer
- Circular RNAs in diseases
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Sperm and Testicular Function
- Pregnancy and preeclampsia studies
- Genetics and Neurodevelopmental Disorders
- Cancer-related Molecular Pathways
- Sexual Differentiation and Disorders
- Birth, Development, and Health
- Epigenetics and DNA Methylation
- Cancer-related gene regulation
- Acute Myeloid Leukemia Research
- Wnt/β-catenin signaling in development and cancer
- Immune Cell Function and Interaction
- Migraine and Headache Studies
- Autism Spectrum Disorder Research
- Reproductive Biology and Fertility
- Genomic variations and chromosomal abnormalities
- Reproductive System and Pregnancy
- RNA regulation and disease
- Endometriosis Research and Treatment
- Uterine Myomas and Treatments
- Genetic Associations and Epidemiology
Shahid Beheshti University of Medical Sciences
2016-2025
Institute for Health Metrics and Evaluation
2022-2024
University of Washington
2022-2024
Tehran University of Medical Sciences
2021-2023
Ahvaz Jundishapur University of Medical Sciences
2023
Zabol University of Medical Sciences
2023
Emami (India)
2023
University of Electronic Science and Technology of China
2023
Shahid Beheshti University
2019
Medical Genetics Center
2018
Breast cancer is a molecularly heterogeneous disease which necessitates search for markers to provide more specific classification of this disorder. Long noncoding RNAs as the important subset transcripts have been shown be involved in tumorigenic processes. So, they may used early detection and evaluation prognosis. In addition, can applied therapeutic targets. study, we analyzed expression four long (lncRNAs) namely SOX2OT, PTPRG-AS1, ANRASSF1, ANRIL 38 breast tissues their adjacent...
Current cancer treatments have unexpected side effects of which the death normal cells is one. In some cancers, iron nanoparticles (NPs) can be subjected to diagnosis and passive targeting treatment. Cold atmospheric plasma (CAP) has a proven induction selective cell ability. this study, we attempted analyze synergy between CAP NPs in human breast adenocarcinoma (MCF-7).In vitro cytotoxicity treatment measured by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay was...
Autism spectrum disorder (ASD) as a synaptopathy is revealed to be pertained aberrant glutamatergic neurotransmission. Glutamate receptor, metabotropic 7 ( GRM7 ), receptor coding gene of this pathway, new candidate for autism. The aim study was examine if there relationship between genetic variants rs779867 and rs6782011 with ASD. present research designed population‐based, case–control including 518 ASD patients versus 472 control individuals. results showed that the frequency G/G genotype...
Considerable research shows that long non-coding RNAs, those longer than 200 nucleotides, are involved in several human diseases such as various cancers and cardiovascular diseases. Their significant role regulating the function of endothelial cells, smooth muscle macrophages, vascular inflammation, metabolism indicates possible effects lncRNAs on progression atherosclerosis which is most common underlying pathological process responsible for coronary artery disease (CAD). The aim present...
Recent studies have suggested that single-nucleotide polymorphisms (SNPs) in miRNA genes or their binding sites may alter an individual's susceptibility to coronary artery disease (CAD). In the present study, association between two such SNPs (rs2910164 miR-146a and rs12190287, which disrupts TCF21) CAD, Iranian population, was evaluated silico analyses were conducted predict disease-related effects of rs2910164.The study population consisted angiographically confirmed CAD patients (n = 300)...
Docetaxel acts through the inhibition of tubulin polymerization and reduction in expression BCL-2 gene. In this study, nanoparticles containing were prepared their effects on gene levels BAX genes investigated. The drug was first conjugated to chitosan, assembled presence hyaluronic acid. Conjugations confirmed by 1 H-NMR, obtained characterized dynamic light scattering SEM. Cytotoxicity nanoparticles, cellular uptake, cell death evaluated. Finally, effect MCF-7 cells investigated real-time...
ABSTRACT Background The activin A receptor type 2A gene ( ACVR2A ) plays an important role in normal gestation, particularly decidualization, trophoblastic invasion, and placentation. Although several studies have investigated the association between maternal variants preeclampsia (PE) susceptibility; however, controversial results were obtained. Moreover, none of previous studies, fetal was explored. aim present study to investigate rs1424954 rs1424941 polymorphisms PE susceptibility...
Knobloch Syndrome (KS) is a rare genetic disorder characterized by ocular abnormalities and central nervous system (CNS) defects, which are attributed to collagenopathy. The primary gene implicated in KS <em>COL18A1</em>, encodes the alpha chain of type XVIII collagen. This collagen functions as proteoglycan, predominantly located basement membrane human tissues. study examined an Iranian female presenting with symptoms horizontal nystagmus, strabismus, suspected vision loss,...
Breast cancer accounts for one third of new cases among women. The need biomarkers early detection is the stimulus to researchers evaluate altered expression genes in tumours. Cancer-testis (CT) are a group with limited normal tissues except testis but up-regulation wide variety cancers. We here evaluated two CT named FBXO39 and TDRD4 32 invasive ductal carcinoma samples, 10 fibroadenomas 6 breast tissue addition cell lines, MCF-7 MDA-MB-231, by means quantitative real time RT-PCR. showed...
Lactobacilli are a group of beneficial bacteria whose anti cancer effects have been evaluated in different cell lines as well animal models and human subjects. Such can be exerted via mechanisms such modulation immune response inhibition pathogens colonization. In addition, lactobacilli direct cytotoxic against cells which may through expression related pathways.The aim this study is to find the mechanism two strains, Lactobacillus. crispatus (LC) rhamnosus (LR).We analyzed some mTOR Wnt/...
Hypoxia‐inducible factors (HIFs) have been shown to be upregulated in tumor tissues and linked with progression metastasis breast cancer. Among regulatory mechanisms for HIF expression is a natural occurring antisense named aHIF , which has overexpressed cancer influence the level of HIF‐1α transcript. In present study, we analyzed versus adjacent noncancer (ANCTs) relation clinical biological behavior tumors. expressed 67.4% invasive ductal carcinoma samples, while none ANCTs showed its...
Hypoxia-Inducible Factor (HIF)-1 plays an essential role in the body's response to low oxygen concentrations and regulates expression of several genes implicated homeostasis, vascularization, anaerobic metabolism as well immunological responses. Increased levels HIF-1α are associated with increased proliferation more aggressive breast tumor development. Lactobacilli have been shown exert anti-cancer effects on malignancies including cancer. However, exact mechanism such effect is not clear...
Genes involved in piwi-interacting RNAs (piRNAs) pathway have an essential role spermatogenesis. HIWI and TDRD proteins are critical for piRNA biogenesis function. Therefore, Mutations polymorphisms genes may play male infertility. The aim of the present study was to investigate HIWI2 rs508485 (T>C) HIWI3 rs11703684 (C>T) mutational analysis TDRD5 gene idiopathic non-obstructive azoospermia a case-control including 226 patients 200 fertile males. Genotyping both performed using Tetra-Primer...