A5011518097- Nanoparticle-Based Drug Delivery
- RNA Interference and Gene Delivery
- Advanced Drug Delivery Systems
- Advanced biosensing and bioanalysis techniques
- Nanoplatforms for cancer theranostics
- Graphene and Nanomaterials Applications
- Drug Solubulity and Delivery Systems
- Electrospun Nanofibers in Biomedical Applications
- Advancements in Transdermal Drug Delivery
- Corneal Surgery and Treatments
- Immunotherapy and Immune Responses
- Ocular Surface and Contact Lens
- Silk-based biomaterials and applications
- Lipid Membrane Structure and Behavior
- Dendrimers and Hyperbranched Polymers
- Hydrogels: synthesis, properties, applications
- Monoclonal and Polyclonal Antibodies Research
- MicroRNA in disease regulation
- Adenosine and Purinergic Signaling
- biodegradable polymer synthesis and properties
- Protein purification and stability
- 3D Printing in Biomedical Research
- Pancreatic function and diabetes
- Extracellular vesicles in disease
- Cancer Treatment and Pharmacology
Tehran University of Medical Sciences
2016-2025
Razi Hospital
2023
Iran University of Medical Sciences
2016-2021
Shahed University
2021
Guilan University of Medical Sciences
2019
American Pharmacists Association
2011-2018
Stem Cell Technology Research Center
2018
Tarbiat Modares University
2018
Noor Eye Hospital
2018
University of Tehran
2005-2017
Background: Low drug entrapment efficiency of hydrophilic drugs into poly(lactic-co-glycolic acid) (PLGA) nanoparticles is a major drawback. The objective this work was to investigate different methods producing PLGA containing minocycline, suitable for periodontal infections. Methods: Different methods, such as single and double solvent evaporation emulsion, ion pairing, nanoprecipitation were used prepare both PEGylated nanoparticles. resulting analyzed their morphology, particle size...
For folate-receptor-targeted anticancer therapy, docetaxel (DTX) nanoparticles (NPs) were produced employing polylactide-co-glycolide–polyethylene glycol–folate (PLGA–PEG–FOL) conjugate. The FOL-conjugated di-block copolymer was synthesized by coupling the PLGA–PEG–NH2 with an activated folic acid. It expected that FOL moieties exposed on micellar surface.The conjugates assisted in formation of DTX NPs average size 200 nm diameter through emulsification/solvent diffusion method. FOL-targeted...
Background: Targeting drugs to their sites of action overcome the systemic side effects associated with most antineoplastic agents is still a major challenge in pharmaceutical research. In this study, monoclonal antibody, trastuzumab, was used as targeting agent nanoparticles carrying antitumor drug, doxorubicin, specifically its site action. Methods: Chitosan-doxorubicin conjugation carried out using succinic anhydride crosslinker. Trastuzumab conjugated self-assembled chitosan-doxorubin...
Nanoparticles have proven to be an effective delivery system with few side effects for anticancer drugs. In this study, gemcitabine-loaded nanoparticles been prepared by ionic gelation method using chitosan and Pluronic(®) F-127 as a carrier. Prepared were characterized dynamic light scattering, Fourier transform infrared spectroscopy (FT-IR), differential scanning calorimetry (DSC), electron microscopy, transmission microscopy. Different parameters such concentration of sodium...
Several chemo-drugs act as the biocompatible fluorophores. Here, laser induced fluorescence (LIF) properties of doxorubicin, paclitaxel and bleomycin are investigated. The absorption lines mostly lie over UV range according to UV-VIS spectra. Therefore, a single XeCl provokes desired transitions interest at 308 nm. It is shown that LIF spectra strongly dependent on fluorophore concentration giving rise sensible red shift. This happens when large overlapping area appears between emission...
The aim of this study was to prepare and evaluate mucoadhesive core-shell nanoparticles based on copolymerization thiolated chitosan coated poly methyl methacrylate cores as a carrier for oral delivery docetaxel. Docetaxel-loaded with various concentrations were prepared via radical emulsion polymerization method using cerium ammonium nitrate an initiator. physicochemical properties the obtained characterized by: dynamic light-scattering analysis their mean size, size distribution, zeta...