A5102926643- Immune cells in cancer
- Immunotherapy and Immune Responses
- Mathematical Biology Tumor Growth
- Immune Cell Function and Interaction
- Adenosine and Purinergic Signaling
- Histone Deacetylase Inhibitors Research
- Epigenetics and DNA Methylation
- Cancer Immunotherapy and Biomarkers
- Cancer Cells and Metastasis
- T-cell and B-cell Immunology
- Pregnancy and Medication Impact
- Childhood Cancer Survivors' Quality of Life
- Monoclonal and Polyclonal Antibodies Research
- Dental Radiography and Imaging
- Nanoplatforms for cancer theranostics
- CAR-T cell therapy research
- Gene Regulatory Network Analysis
- Oropharyngeal Anatomy and Pathologies
- Maternal Mental Health During Pregnancy and Postpartum
- Cerebrovascular and Carotid Artery Diseases
- Chemokine receptors and signaling
- Pharmacological Effects of Natural Compounds
- COVID-19 Impact on Reproduction
- Cancer, Stress, Anesthesia, and Immune Response
- Antimicrobial Peptides and Activities
Tarbiat Modares University
2015-2022
Stony Brook University
2022
University of San Francisco
2021
Dendritic cells are important in initiating immune responses; therefore, a range of dendritic cell–based approaches have been established to induce response against cancer cells. However, the presence immunosuppressive mediators such as adenosine tumor microenvironment reduces efficacy immunotherapy. In this study, we investigated whether blockade A2A receptor with selective antagonist and CD73 inhibitor may increase vaccine. According findings, therapeutic combination reduced growth,...
Different cells and mediators in the tumor microenvironment play important roles progression of breast cancer. The aim this study was to determine composition during order discover new related biomarkers potentials for targeted therapy.In study, cancer biopsies from four different stages, control were collected. Then, mRNA expression several markers CD4+ T cell subsets including regulatory (Treg), helper (Th) type 1, 2 17 determined. In addition, we investigated two inflammatory cytokines...
We assessed the effect of sodium butyrate (SB) as a histone deacetylase inhibitor (HDACi) on Toll-like receptor 4 (TLR4) gene expression levels, in low TLR4 expressing (HCT116) and high (SW480) colorectal cancer cells. The cytotoxic SB was by culturing SW480 HCT116 cell lines using broad spectrum times concentrations SB. MTT assay done to check properties different concentrations. Gene levels then evaluated for non-cytotoxic Morphological analysis confirmed that equal or less than 5mM were...
This study is designed to present an agent-based model (ABM) simulate the interactions between tumor cells and immune system in melanoma model. The Myeloid-derived Suppressor Cells (MDSCs) dendritic (DCs) are considered this as immunosuppressive antigen-presenting agents respectively. animal experiment was performed on 68 B16F10 tumor-bearing C57BL/6 female mice collect dynamic data for ABM implementation validation. Animals were divided into 4 groups; group 1 control (no treatment) while...
The aim of this study was to determine if a convolutional neural network (CNN) can be trained automatically detect and localize cervical carotid artery calcifications (CACs) in CBCT. A total 56 CBCT studies (15,257 axial slices) were utilized train, validate, test the deep learning model. comprised two steps: Step 1: Localizing slices that are below C2-C3 disc space. For step openly available Inception V3 architecture on ImageNet dataset real-world images, retrained 40 studies. 2: Detecting...
The purpose of this study was the translation and cultural adaptation CLEFT-Q to Farsi evaluating reliability it.The English version translated following guidelines set forth by International Society for Pharmacoeconomics Outcomes Research (ISPOR). To calculate reliability, 50 participants filled out questionnaire twice at 2-week intervals.The difficulties during process were as follows: 7.56% items from independent forward translations, 62.18% comparison between two 21% post-back original...
Abstract CD137 (ILA/4‐1BB), a member of tumor necrosis factor receptor superfamily, is one the most important T cell costimulatory molecules. Interaction this molecule with its ligand transmits two‐way signal that activates both lymphocyte and antigen presenting cells. The soluble form (sCD137) reduces activity membrane isoform associated activation‐induced death. Recombinant CD137‐Fc may be used to treat cancers, autoimmune disorders viral infections. It also useful for management...
Event Abstract Back to Domination of Th17 subpopulation lymphocytes during tumor progression. Maryam Ajami1, 2, Reza Mansouri2 and Jamshid Hadjati1* 1 Tehran university medical sciences, Immunology, Iran 2 Shahid Sadoughi Background: Inflammatory responses play a decisive role in the early stages development, Progress, Invasion metastasis. An inflammatory mechanism is also effective immune surveillance efficacy treatment. The microenvironment consists complex network various cell types...