A5083882203- Cancer-related molecular mechanisms research
- Molecular Biology Techniques and Applications
- Synthesis and biological activity
- Circular RNAs in diseases
- MicroRNA in disease regulation
- BRCA gene mutations in cancer
- Quinazolinone synthesis and applications
- CRISPR and Genetic Engineering
- RNA Research and Splicing
- Cancer Mechanisms and Therapy
- Click Chemistry and Applications
- Aluminum Alloys Composites Properties
- Estrogen and related hormone effects
- HER2/EGFR in Cancer Research
- Monoclonal and Polyclonal Antibodies Research
- Angiogenesis and VEGF in Cancer
- Cancer-related Molecular Pathways
- Cancer Genomics and Diagnostics
- Molecular Sensors and Ion Detection
- Synthesis and Biological Evaluation
- Pharmacogenetics and Drug Metabolism
- Genetics, Bioinformatics, and Biomedical Research
- Mesenchymal stem cell research
- Analytical Chemistry and Sensors
- Synthesis and Characterization of Heterocyclic Compounds
Motamed Cancer Institute
2015-2024
Academic Center for Education, Culture and Research
2015-2024
The University of Texas MD Anderson Cancer Center
2024
Islamic Azad University of Najafabad
2024
Tarbiat Modares University
2015-2021
Cancer Genetics (United States)
2016-2018
Shahid Bahonar University of Kerman
2013-2015
Breast Cancer Research Foundation
2013
Biomedical researchers have long looked for ways to diagnose and treat cancer patients at the early stages through biomarkers. Although conventional techniques are routinely applied in detection of biomarkers, attitudes towards using Real-Time PCR many biomarkers increasing. Normalization quantitative is necessary validate non-biological alteration occurring during steps RNA quantification. Selection variably expressed housekeeping genes (HKs) will affect validity data. The aim present study...
Different cells and mediators in the tumor microenvironment play important roles progression of breast cancer. The aim this study was to determine composition during order discover new related biomarkers potentials for targeted therapy.In study, cancer biopsies from four different stages, control were collected. Then, mRNA expression several markers CD4+ T cell subsets including regulatory (Treg), helper (Th) type 1, 2 17 determined. In addition, we investigated two inflammatory cytokines...
Purpose: Bone marrow-derived mesenchymal stem cells (MSCs) have the potential ability to differentiate into bone, muscle, fat, and cartilage lineage cells. Furthermore, MSCs are known migrate tumor-associated stroma of cancer. This tumor microenvironment consists a dynamic network growth factors, immune cells, fibroblasts, extracellular matrix, MSCs. as nonhematopoietic affect tumor, epithelial by alteration proliferative capacity, morphology, aggregation pattern Materials Methods: research...
Abstract The present study aimed to improve the understanding of non-uterine leiomyosarcoma (NULMS) prognostic genes through system biology approaches. This cancer is heterogeneous and rare. Moreover, gene interaction networks have not been reported in NULMS yet. datasets were obtained from public expression databases. Seven co-expression modules identified 5000 most connected genes; using weighted network analysis. Using Cox regression, showed favorable (HR = 0.6, 95% CI 0.4–0.89, P...
Background: Breast cancer accounts about one million from total annual ten new diagnosed cases of neoplasia worldwide and is the main cause death due to in women. Tamoxifen most popular selective estrogen receptor modulator used anti treatments. must be converted into its metabolite endoxifen for biologic effects; this conversion process catalysed by highly polymorphic cytochrome P450 2D6 (CYP2D6). This study surveyed copy number variation CYP2D6 gene possible correlation with resistance...
The expression level of NDRG3 gene is investigated among breast cancer (BC) patients.Real-time quantitative PCR was performed. downregulated in BC patients particularly advanced stage the disease. HER2 status significantly correlated with NDRG3. Also, triple-negative showed low levels comparison to other subtypes. Lastly, had significant impact on survival, having worst event-free survival rate others.We have presented that might be a tumor suppressor candidate. downregulation involved...