A5014784394- Immune Cell Function and Interaction
- Adenosine and Purinergic Signaling
- Immunotherapy and Immune Responses
- RNA Interference and Gene Delivery
- T-cell and B-cell Immunology
- Immune cells in cancer
- Cancer Immunotherapy and Biomarkers
- Nanoplatforms for cancer theranostics
- Advanced Breast Cancer Therapies
- HIV Research and Treatment
- Erythrocyte Function and Pathophysiology
- Cancer, Lipids, and Metabolism
- Estrogen and related hormone effects
- Graphene and Nanomaterials Applications
- Immune Response and Inflammation
- CAR-T cell therapy research
- Bacterial Infections and Vaccines
- Phagocytosis and Immune Regulation
- Inflammatory mediators and NSAID effects
- Cancer, Hypoxia, and Metabolism
- Advanced Glycation End Products research
- Sphingolipid Metabolism and Signaling
- Liver physiology and pathology
- Circular RNAs in diseases
- Ginger and Zingiberaceae research
University of Alberta
2017-2024
Tehran University of Medical Sciences
2009-2017
Colorectal cancers (CRCs) deficient in DNA mismatch repair (dMMR) contain abundant CD8+ tumor-infiltrating lymphocytes (TILs) responding to the neoantigens from their unstable genomes. Priming of such tumor-targeted TILs first requires recruitment T cells into tumors, implying that this is an essential prerequisite successful dMMR anti-tumor immunity. We have discovered selective and activation systemic CRCs strictly depend on overexpression CCL5 CXCL10 due endogenous cGAS/STING type I IFN...
Summary Dendritic cell (DC) ‐based cancer immunotherapy is one of the most important anti‐cancer immunotherapies, and has been associated with variable efficiencies in different types. It well‐known that tumor microenvironment plays a key role efficacy various immunotherapies such as DC vaccine. Accordingly, expression programmed death ligand 1 (PD‐L1) on DCs, which interacts PD‐1 T cells, leads to inhibition anti‐tumor responses following presentation antigens by DCs cells. Therefore, we...
Cell-surface transferrin receptor (CD71+) erythroid cells are abundant in newborns with immunomodulatory properties. Here, we show that neonatal CD71+ express significant levels of V-domain Immunoglobulin (Ig) Suppressor T Cell Activation (VISTA) and, via constitutive production transforming growth factor (TGF)- β, play a pivotal role promotion naïve CD4+ into regulatory (Tregs). Interestingly, discovered CD71+VISTA+ produce significantly higher TGF-β compared to CD71+VISTA− and from the...
Abstract Newborns are highly susceptible to infection. The underlying mechanism of neonatal infection susceptibility has generally been associated with immune cell immaturity. In this study, we challenged notion and built upon our recent discovery that neonates physiologically enriched erythroid TER119+CD71+ cells (Elahi et al. 2013. Nature 504: 158–162). We have used Bordetella pertussis, a common respiratory tract infection, as proof concept investigate the role these in newborns. found...
Type III interferons (IFN-lambdas(λ)) are important cytokines that inhibit viruses and modulate immune responses by acting through a unique IFN-λR1/IL-10RB heterodimeric receptor. Until now, the primary antiviral function of IFN-λs has been proposed to be at anatomical barrier sites. Here, we examine regulation IFN-λR1 expression measure downstream effects IFN-λ3 stimulation in human blood cells, compared with lung or liver epithelial cells. directly bound upregulated IFN-stimulated gene...
Dendritic cells are important in initiating immune responses; therefore, a range of dendritic cell–based approaches have been established to induce response against cancer cells. However, the presence immunosuppressive mediators such as adenosine tumor microenvironment reduces efficacy immunotherapy. In this study, we investigated whether blockade A2A receptor with selective antagonist and CD73 inhibitor may increase vaccine. According findings, therapeutic combination reduced growth,...
Infant's immune system cannot control infection or respond to vaccination as efficiently older individuals, a phenomenon that has been attributed immunological immaturity. Recently, we challenged this notion and proposed the presence of actively immunosuppressive physiologically enriched CD71+ erythroid cells in neonates. Here utilized Bordetella pertussis, common neonatal respiratory tract pathogen, proof concept investigate role these adaptive immunity. We observed have distinctive...
Abstract Inhibitory immune checkpoint (ICP) molecules are important immunosuppressive factors in a tumor microenvironment (TME). They can robustly suppress T‐cell‐mediated antitumor responses leading to cancer progression. Among the molecules, cytotoxic T‐lymphocyte‐associated protein‐4 (CTLA‐4) is one of critical inhibitors anticancer T‐cell responses. Besides, expression adenosine receptor (A2AR) on tumor‐infiltrating T cells potently reduces their function. We hypothesized that...
CD71+ erythroid cells (CECs) have a wide range of immunomodulatory properties. Here, we show that CECs are expanded in the peripheral blood HIV patients, with positive correlation between their frequency and plasma viral load. from patients human cord blood/placenta exacerbate HIV-1 infection/replication when cocultured CD4+ T cells, preexposure to enhances permissibility infection. However, mature red (RBCs) do not enhance replication cells. We also found express substantial levels NOX2...
Regulation of T cell function in the steady state is mediated by co-inhibitory receptors or immune checkpoints such as PD-1, CTLA-4, TIM-3 and LAG-3. Persistent antigen stimulation, during chronic viral infections cancer, results sustained expression multiple subsequently poor effector function. Immune checkpoint blockade using monoclonal antibodies against PDL-1 CTLA-4 has been implemented an immunotherapy strategy- resulting restoration reduction load tumour growth. Immunomodulatory roles...