A5013375880- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Immunotherapy and Immune Responses
- Nuclear Receptors and Signaling
- Cancer Immunotherapy and Biomarkers
- HIV Research and Treatment
- Immune Response and Inflammation
- Hepatitis C virus research
- Whipple's Disease and Interleukins
- Microscopic Colitis
- Macrophage Migration Inhibitory Factor
- Chemokine receptors and signaling
- Cytokine Signaling Pathways and Interactions
- interferon and immune responses
- Pain Mechanisms and Treatments
- Exercise and Physiological Responses
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Algorithms and Data Compression
University of Alberta
2020-2024
Type III interferons (IFN-lambdas(λ)) are important cytokines that inhibit viruses and modulate immune responses by acting through a unique IFN-λR1/IL-10RB heterodimeric receptor. Until now, the primary antiviral function of IFN-λs has been proposed to be at anatomical barrier sites. Here, we examine regulation IFN-λR1 expression measure downstream effects IFN-λ3 stimulation in human blood cells, compared with lung or liver epithelial cells. directly bound upregulated IFN-stimulated gene...
Highly self-reactive T cells are censored from the repertoire by both central and peripheral tolerance mechanisms upon receipt of high-affinity TCR signals. Clonal deletion is considered a major driver tolerance; however, other such as induction regulatory functional impairment have been described. An understanding interplay between these different still lacking. We previously showed that impaired clonal to model tissue-restricted Ag did not compromise tolerance. In this study, we determined...
Abstract Several coinhibitory receptors are upregulated upon activation, whereas a small number of expressed constitutively by naive T cells. The relationship between coinhibitors is unknown. We found an inverse two coinhibitors, CD5 and BTLA; BTLA expression was low in the thymus high periphery, corresponding respectively with expression. Germline or induced deletion Btla somatic cells demonstrated causal levels central peripheral lymphoid tissues. effect on thymic CD4 due to signaling,...
Immunologic self-tolerance involves signals from co-inhibitory receptors. Several T cell co-inhibitors, including PD-1, are expressed upon activation, whereas CD5 and BTLA constitutively. The relationship between constitutively co-inhibitors when they needed is unknown. Deletion of Btla demonstrated regulates expression. Loss signals, but not signalling by its ligand, HVEM, leads to increased Higher expression set during thymic selection associated with self-recognition, suggesting that...
Several unique waves of γδ T cells are generated solely in the fetal/neonatal thymus, whereas additional cell subsets adults. One intriguing feature development is coordination differentiation and acquisition effector function within fetal thymus; however, it less clear whether this paradigm holds true adult animals. In study, we investigated relationship between maturation thymic export adult-derived thymocytes mice. Rag2pGFP model, immature (CD24+) expressed high levels GFP only a minority...
Abstract Highly self-reactive T cells are censored from the repertoire by both central and peripheral tolerance mechanisms upon receipt of high-affinity TCR signals. Clonal deletion is considered a major driver tolerance; however, other such as induction regulatory functional impairment have been described. An understanding interplay between these different still lacking. We previously showed that impaired clonal to model tissue-restricted antigen (TRA) did not compromise tolerance. In this...
Abstract Type III interferons (IFN-lambdas(λ)) are the most recently discovered interferon cytokine family that inhibit viruses by signaling through a unique IFN-λR1/IL-10RB heterodimeric receptor. Until now, IFN-λs were thought to primarily act on anatomical barrier epithelial cells, neutrophils and subset of dendritic although majority studies have been performed in mice. Here, we examine regulation IFN-λR1 expression downstream effects IFN-λ3 stimulation primary human blood immune cells...