A5100776174- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Melanoma and MAPK Pathways
- Plasma Applications and Diagnostics
- Cell death mechanisms and regulation
- CAR-T cell therapy research
- Immune Response and Inflammation
- NF-κB Signaling Pathways
- Listeria monocytogenes in Food Safety
- Immunotherapy and Immune Responses
- Retinoids in leukemia and cellular processes
- Essential Oils and Antimicrobial Activity
- Quinazolinone synthesis and applications
- Ubiquitin and proteasome pathways
- Microbial Inactivation Methods
- Chronic Myeloid Leukemia Treatments
- Protein Kinase Regulation and GTPase Signaling
- Soil Carbon and Nitrogen Dynamics
- Autophagy in Disease and Therapy
- Mosquito-borne diseases and control
- interferon and immune responses
- Monoclonal and Polyclonal Antibodies Research
- Cardiac Ischemia and Reperfusion
- Ovarian cancer diagnosis and treatment
- RNA Research and Splicing
Chengdu Second People's Hospital
2024
China-Japan Friendship Hospital
2022-2024
Northwest Institute For Non-Ferrous Metal Research
2021-2024
Chinese University of Hong Kong, Shenzhen
2023-2024
La Jolla Institute for Immunology
2018-2024
Shandong University of Traditional Chinese Medicine
2024
Academy of Military Medical Sciences
2017-2024
Shenyang Agricultural University
2022-2024
Ministry of Agriculture and Rural Affairs
2022-2024
Oregon State University
2024
Autophagy is essential for maintaining tissue homeostasis. Although adaptors have been demonstrated to facilitate the assembly of Atg14L-Beclin 1-Vps34-Vps15 complex, which functions in autophagosome formation, it remains unknown whether autophagy machinery actively recruits such adaptors. WD40-repeat proteins are a large, highly conserved family implicated various cellular activities. However, role WD40-repeat-only proteins, as RACK1, postnatal mammalian physiology unknown. Here, we report...
Possible mechanisms behind the enhanced antimicrobial activity of gallic acid (GA) and its ester propyl gallate (PG) in presence UV-A light against Escherichia coli O157:H7 were investigated. GA by itself is a mild has pro-oxidant ability. We found that increases uptake bacteria. Once internalized, interaction between induces intracellular ROS formation, leading to oxidative damage. Concurrently, + also inhibits superoxide dismutase (SOD), magnifying imbalance redox status E. O157:H7. In...
c-Jun N-terminal protein kinase (JNK) is a member of the mitogen-activated (MAPK) superfamily. The activation JNK mediated by sequential phosphorylation through MAPK module, namely, (MAP3K or MEKK) → (MAP2K MKK) MAPK. Elevated levels activity have been frequently observed in hepatocellular carcinoma (HCC) and demonstrated to contribute HCC growth promoting cell proliferation resistance tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)- Fas-mediated apoptosis. Chronic...
Zika virus (ZIKV) is an emerging flavivirus that causes congenital syndromes including microcephaly and fetal demise in pregnant women. No commercial vaccines against ZIKV are currently available. We previously generated a chimeric (ChinZIKV) based on the Chaoyang (CYV) by replacing prME protein of CYV with contemporary strain GZ01. Herein, we evaluated this vaccine candidate mouse model showed ChinZIKV was totally safe both adult suckling immunodeficient mice. viral RNA detected serum mice...
Chronic psychological stress has been shown to adversely impact immune system functions and compromise host defenses against various infections. However, the underlying mechanisms remain elusive. Recent studies have demonstrated that myeloid-derived suppressor cells (MDSCs) play an important role in regulating immunity. It is of interest explore whether or not chronic plays immunosuppressive partially by inducing MDSCs accumulation. In this work, we report led accumulation CD11b+Gr1+ bone...
Abstract Hyperactivation of c-Jun NH2-terminal protein kinase (JNK) has been found in various malignant lymphocytes and inhibition JNK activity leads to cell cycle arrest apoptosis. However, the role oncogenic growth T-cell acute lymphoblastic leukemia (T-ALL) cells remains largely unknown. Here, we report that treatment T-ALL with inhibitors led apoptosis increased sensitivity Fas-mediated apoptosis, whereas weak ectopic expression MKK7-JNK1 fusion protein, which shows constitutive...
HVEM is a TNF (tumor necrosis factor) receptor contributing to broad range of immune functions involving diverse cell types. It interacts with ligand, LIGHT, and immunoglobulin (Ig) superfamily members BTLA CD160. Assessing the functional impact binding specific ligands in different settings has been complicated by multiple interactions partners. To dissect molecular basis for functions, we determined crystal structures that reveal distinct surfaces engage LIGHT or BTLA/CD160, including...
Intraepithelial T cells (IETs) are in close contact with intestinal epithelial and the underlying basement membrane, they detect invasive pathogens. How membrane influence IET survival function, at steady state or after infection, is unclear. The herpes virus entry mediator (HVEM), a member of TNF receptor superfamily, constitutively expressed by important for protection from pathogenic bacteria. Here, we showed that steady-state LIGHT, an HVEM ligand, binding to promoted small intestine...
Steady-state extramedullary hematopoiesis during adulthood is an emerging field of great interest. The meninges contain both innate and adaptive immune cells, which provide immunosurveillance the central nervous system (CNS). Hematopoietic progenitors that give rise to meningeal cells remain elusive. Here, we report steady-state adult mice host hematopoietic stem (HSCs), as defined by long-term, efficient, multi-lineage reconstitution self-renewal capacity in meninges, blood, spleen, bone...
Neddylation, an important type of post-translational modification, has been implicated in innate and adapted immunity. But the role neddylation immune response against RNA viruses remains elusive. Here we report that promotes virus-induced I IFN production, especially IFN-α. More importantly, myeloid deficiency UBA3 or NEDD8 renders mice less resistant to virus infection. Neddylation is essential for virus-triggered activation Ifna gene promoters. Further exploration revealed mammalian...
Plasma-activated water (PAW) is considered a novel sanitizer for the food industry due to antimicrobial mechanisms exhibited by reactive oxygen and nitrogen species. The plasma operation parameters can affect chemistry of PAW therefore influence its microbial inactivation efficacy. This study statistically optimized operating conditions (activation time, distance from nozzle, volume water) using response surface methodology. Two were identified planktonic cells avirulent strain Salmonella...
The first-in-class compound MLN4924 is a small molecule inhibitor that selectively inactivates NEDD8-activating enzyme (NAE). anticancer effects of have been attributed to impaired neddylation Cullin proteins. Here, we show treatment T-cell acute lymphoblastic leukemia (T-ALL) cells with potently suppressed the Cullins and oncogenic growth T-ALL in-vitro. Moreover, induced disease regression in an vivo xenograft model. also cell cycle arrest at G2 phase apoptosis cells. However, inhibition...
Peroxiredoxin2 (PRDX2) is a member of the peroxiredoxin family antioxidant enzymes. A number previous studies have indicated that PRDX2 may serve cell type-dependent role in tumorigenesis. Recently, has been identified to be new target miR-122a, which demonstrated frequently downregulated hepatocellular carcinoma (HCC). Thus, pro-tumorigenic HCC. Because HCC not yet reported, it interest explore how affect reactive oxygen species (ROS)-mediated death cells. The present study analyzed effects...
Type I interferons such as interferon-beta (IFN-β) play essential roles in the host innate immune response to herpes simplex virus type (HSV-1) infection. The transcription of interferon genes is controlled by nuclear factor-κB (NF-κB) and regulatory factor (IRF) family members including IRF3. NF-κB activation depends on phosphorylation inhibitor κB (IκB), which triggers its ubiqitination degradation. It has been reported that neddylation inhibition a pharmacological agent MLN4924 potently...
To address the issue of non-standard grain sizes and difficult control uniformity in manufacturing large, complex-shaped nuclear power pipelines. In this paper, double wedge-shaped samples X2 CrNiMo 18.12 (CN) austenitic stainless steel were hot deformed at 1000 °C, 1100 1180 °C to obtain deformation with a gradient strain, sample was subjected solid solution treatment 1060 × 4 h (water quenching; measured cooling rate water approximately 4400 °C/min). Large-area electron backscattered...