Wai Yie Leong

ORCID: 0000-0002-5389-1121
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About
Contact & Profiles
Research Areas
  • Cancer Genomics and Diagnostics
  • Blind Source Separation Techniques
  • Photonic and Optical Devices
  • Bioinformatics and Genomic Networks
  • Silicon Nanostructures and Photoluminescence
  • RNA and protein synthesis mechanisms
  • Dialysis and Renal Disease Management
  • Algorithms and Data Compression
  • Spectroscopy and Chemometric Analyses
  • EEG and Brain-Computer Interfaces
  • Semiconductor materials and devices
  • Diverse Aspects of Tourism Research
  • Genomics and Phylogenetic Studies
  • Electronic Packaging and Soldering Technologies
  • Semiconductor Lasers and Optical Devices
  • Silicon and Solar Cell Technologies
  • VLSI and FPGA Design Techniques
  • Digital Transformation in Industry
  • Transportation Planning and Optimization
  • Gut microbiota and health
  • Semiconductor materials and interfaces
  • Socioeconomic Development in Asia
  • Polymer crystallization and properties
  • Urban Transport and Accessibility
  • 3D IC and TSV technologies

INTI International University
2023-2025

Macau University of Science and Technology
2011-2025

National University Hospital
2012-2024

National University of Singapore
2014-2024

Multimedia University
2008-2024

The University of Sydney
2003-2024

Land Quality Management
2024

Liberal Arts University
2024

Heilongjiang Institute of Technology
2024

University of Malaya
2017-2024

James F. Howard Kimiaki Utsugisawa Michael Benatar Hiroyuki Murai Richard J. Barohn and 95 more Isabel Illa Saiju Jacob John Vissing Ted M. Burns John T. Kissel Srikanth Muppidi Richard J. Nowak Fanny O’Brien Jingjing Wang Renato Mantegazza Claudio Mazia Miguel Wilken Carolina Ortea Juliet Saba Marcelo Rugiero Mariela Bettini Gonzalo Vidal Alejandra Dalila Garcia Phillipa J. Lamont Wai Yie Leong Heidi Boterhoven Beverly Fyfe L. Jackson Roberts Mahi Jasinarachchi Natasha Willlems Julia Wanschitz Wolfgang N. Löscher Jan De Bleecker Guy Van den Abeele Kathy de Koning Katrien De Mey Rudy Mercelis Linda Wagemaekers Délphine Mahieu Philip Van Damme Charlotte Smetcoren Olivier Stevens Sarah Verjans Ann D’Hondt Petra Tilkin Alzira Alves de Siqueira Carvalho Rosa Hasan Igor Dias Brockhausen David Feder Daniel Ambrosio Ana Paula Souto Melo Rosana Rocha Bruno Bezerra Rosa Thabata Veiga Luiz Augusto da Silva Jordana Gonçalves Geraldo Maria da Penha Morita Ananias Érica Coelho Gabriel Pina Paiva M Tovar Pozo Natalia Prando Debora Dada Martineli Torres Cristiani Fernanda Butinhao Érica Coelho Luciana Renata Cubas Volpe Gustavo Duran Tamires Cristina Gomes da Silva Luiz Otavio Maia Gonçalves Lucas Eduardo Pazetto Luciana Souza Duca Tomás Augusto Suriane Fialho Maurício Friedrich Alexandre Guerreiro Henrique Mohr Maurer Pereira Martins Daiane da Cruz Pacheco Ana Paula Macagnan Aline de Cassia Santos Acary Souza Bullé Oliveira Ana Carolina Amaral de Andrade Marcelo Annes Valéria Cavalcante Lino Wladimir Bocca Vieira de Rezende Pinto Carolina Miranda Fernanda Carrara Iandra Souza Angela Genge Rami Massie Natasha Campbell Vera Bril Hans Katzberg Mehran Soltani Eduardo Ng Zaeem A. Siddiqi Celile Phan Derrick Blackmore Stanislav Voháňka Josef Bednařík Magda Chmelikova Marek Čierny

10.1016/s1474-4422(17)30369-1 article EN The Lancet Neurology 2017-10-23

Herpes simplex virus (HSV) infections are endemic, but the clinical characteristics of newly acquired HSV type 1 (HSV-1) and 2 (HSV-2) in adults have not been rigorously defined. We monitored 2393 sexually active HSV-2-seronegative persons for serologic evidence new infection. Of participants, 1508 were seropositive HSV-1 885 seronegative. Charts reviewed a blinded manner classification those with genitourinary or oropharyngeal symptoms. also all 174 seroconversion.The rates HSV-2 1.6 5.1...

10.1056/nejm199911043411904 article EN New England Journal of Medicine 1999-11-04

ContextIn the last 3 decades, herpes simplex virus type 2 (HSV-2) infection seroprevalence and neonatal have increased substantially. An effective vaccine for prevention of genital could help control this epidemic.ObjectiveTo evaluate efficacy a HSV-2 infection.DesignTwo randomized, double-blind, placebo-controlled multicenter trials recombinant subunit containing 30 µg each major surface glycoproteins (gB2 gD2) against which neutralizing antibodies are directed, administered at months 0, 1,...

10.1001/jama.282.4.331 article EN JAMA 1999-07-28

Microporous and mesoporous Si layers contain a very large surface area that affects both their optical electrical properties. Secondary ion mass spectroscopy (SIMS) analysis is used for the first time to simultaneously monitor all major impurities on surface. SIMS data microporous layer demonstrate its chemical composition changes dramatically with during ambient air exposure. Similar trends are observed layers. Extended storage in at room temperature converts hydride of freshly anodized...

10.1063/1.350293 article EN Journal of Applied Physics 1991-07-01

Abstract Background The picturesque limestone karsts across the Sino-Vietnamese border are renowned biodiversity hotspot, distinguished for extremely high endemism of calciphilous plants restricted to caves and cave-like microhabitats that have functioned as biological refugia on otherwise harsh habitats. To understand evolutionary mechanisms underlying splendid flora, dated phylogeny is reconstructed Asian Begonia , a species-rich genus substrates represented by no less than 60 species in...

10.1186/1999-3110-55-1 article EN cc-by Botanical studies 2014-01-07

Abstract Purpose: Existing cell-free DNA (cfDNA) methods lack the sensitivity needed for detecting minimal residual disease (MRD) following therapy. We developed a test tracking hundreds of patient-specific mutations to detect MRD with 1,000-fold lower error rate than conventional sequencing. Experimental Design: compared our approach digital droplet PCR (ddPCR) in dilution series, then retrospectively identified two cohorts patients who had undergone prospective plasma sampling and clinical...

10.1158/1078-0432.ccr-19-3005 article EN Clinical Cancer Research 2020-03-13

10.1016/j.jretconser.2024.103781 article EN Journal of Retailing and Consumer Services 2024-03-02

The integration of Artificial Intelligence (AI) into education has the potential to revolutionize traditional learning methodologies, offering personalized experiences, optimizing administrative tasks, and enabling educators make data-driven decisions. This paper provides a comprehensive review current landscape AI in education, covering various applications such as intelligent tutoring systems, platforms, automated grading educational analytics. Additionally, it discusses challenges ethical...

10.1049/icp.2024.4341 article EN IET conference proceedings. 2025-01-01

Abstract Three types of mineral fillers—talc, calcium carbonate (CaCO 3 ), and kaolin (10–40 wt % filler loadings)—were compounded with polypropylene (PP) a twin‐screw extruder. The composites were injection‐molded, the effects loading on mechanical, flow, thermal properties for three different filled investigated. aim was to compare their deduce prospective combinations that would yield hybrid PP in following studies. results showed most cases, strength stiffness talc‐filled significantly...

10.1002/app.13542 article EN Journal of Applied Polymer Science 2004-01-16

Abstract Human adult dental pulp stem cells (DPSCs), derived from third molar teeth, are multipotent and have the capacity to differentiate into neurons under inductive conditions both in vitro following transplantation avian embryo. In this study, we demonstrate that intracerebral of human DPSCs 24 hours focal cerebral ischemia a rodent model resulted significant improvement forelimb sensorimotor function at 4 weeks post-treatment. At time, 2.3 ± 0.7% engrafted had survived poststroke brain...

10.5966/sctm.2011-0039 article EN cc-by-nc Stem Cells Translational Medicine 2012-02-22

Silicone has been used for peritoneal dialysis (PD) catheters several decades. However, bacteria, platelets, proteins, and other biomolecules tend to adhere its hydrophobic surface, which may lead PD outflow failure, serious infection, or even death. In this work, a cross-linked poly(poly(ethylene glycol) dimethacrylate) (P(PEGDMA)) polymer layer was covalently grafted on medical-grade silicone surface improve antibacterial antifouling properties. The P(PEGDMA)-grafted (Silicone-g-P(PEGDMA))...

10.1021/la303438t article EN Langmuir 2012-11-02

Protein complexes are fundamental for understanding principles of cellular organizations. As the sizes protein–protein interaction (PPI) networks increasing, accurate and fast protein complex prediction from these PPI can serve as a guide biological experiments to discover novel complexes. However, it is not easy predict networks, especially in situations where network noisy still incomplete. Here, we study use indirect interactions between level-2 neighbors (level-2 interactions)...

10.1142/s0219720008003497 article EN Journal of Bioinformatics and Computational Biology 2008-06-01

Abstract The pantropical genus Begonia is the sixth–largest of flowering plants, including 1870 species. sections are used frequently as analogues to genera in other families but, despite their taxonomic utility, few current have been examined light molecular phylogenetic analyses. We present herein largest, most representative phylogeny published date and a subsequent provisional sectional classification genus. utilised three plastid markers for 574 species 809 accessions Hillebrandia an...

10.12705/672.3 article EN Taxon 2018-01-25

The roles of human serum IgA, in contrast to that mucosal are relatively unexplored. Previous studies have shown IgA mediates either pro- or anti-inflammatory effects innate immune cells. Serum has been interact with many proteins and glycoproteins which the functions mechanisms not fully characterized. Here, we present fresh perspectives into describing novel IgA-protein interactions, importance its glycosylation status normal functions, plausible role as a driver regulator autoimmune...

10.1089/dna.2014.2639 article EN DNA and Cell Biology 2014-09-05

Abstract RNA editing and splicing are the two major processes that dynamically regulate human transcriptome diversity. Despite growing evidence of crosstalk between enzymes (mainly ADAR1) machineries, detailed mechanistic explanations their biological importance in diseases, such as cancer still lacking. Herein, we identify approximately a hundred high-confidence events altered by ADAR1 and/or ADAR2, or ADAR2 protein can cassette exons both directions. We unravel binding tendency ADARs to...

10.1038/s41467-020-14621-5 article EN cc-by Nature Communications 2020-02-07
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