A5024392666- Cancer Genomics and Diagnostics
- Breast Cancer Treatment Studies
- BRCA gene mutations in cancer
- Cancer survivorship and care
- Neutropenia and Cancer Infections
- Genetic factors in colorectal cancer
- Cancer Risks and Factors
- Childhood Cancer Survivors' Quality of Life
- Global Cancer Incidence and Screening
- Acute Myeloid Leukemia Research
- Family Support in Illness
- Cancer Cells and Metastasis
- Reproductive Biology and Fertility
- Advanced Breast Cancer Therapies
- Cancer Treatment and Pharmacology
- Palliative Care and End-of-Life Issues
- Economic and Financial Impacts of Cancer
- HER2/EGFR in Cancer Research
- Breast Implant and Reconstruction
- Multiple and Secondary Primary Cancers
- Reproductive Health and Technologies
- Medication Adherence and Compliance
- Cancer-related cognitive impairment studies
- Patient-Provider Communication in Healthcare
- Epigenetics and DNA Methylation
Weill Cornell Medicine
2021-2025
Cornell University
2008-2025
Harvard University
2014-2024
Dana-Farber Cancer Institute
2015-2024
Dana-Farber Brigham Cancer Center
2016-2024
Memorial Sloan Kettering Cancer Center
2007-2023
Flinders University
2023
Brigham and Women's Hospital
2013-2019
Massachusetts Department of Public Health
2015
Beth Israel Deaconess Medical Center
2013
Introduction Ductal carcinoma in situ (DCIS) is a non-invasive non-obligate precursor of invasive breast cancer. With guideline concordant care (GCC), DCIS outcomes are at least as favourable some other early stage cancer types such prostate cancer, for which active surveillance (AS) standard option. However, AS has not yet been tested relation to DCIS. The goal the COMET (Comparison Operative versus Monitoring and Endocrine Therapy) trial low-risk gather evidence help future patients...
Chinese translationRates of contralateral prophylactic mastectomy (CPM) have increased dramatically, particularly among younger women with breast cancer, but little is known about how approach the decision to CPM.To examine preferences, knowledge, making, and experiences young cancer who choose CPM.Cross-sectional survey.8 academic community medical centers that enrolled 550 diagnosed at age 40 years or between November 2006 2010.123 without bilateral reported having mastectomy.A 1-time,...
Abstract Purpose: Existing cell-free DNA (cfDNA) methods lack the sensitivity needed for detecting minimal residual disease (MRD) following therapy. We developed a test tracking hundreds of patient-specific mutations to detect MRD with 1,000-fold lower error rate than conventional sequencing. Experimental Design: compared our approach digital droplet PCR (ddPCR) in dilution series, then retrospectively identified two cohorts patients who had undergone prospective plasma sampling and clinical...
The ATEMPT trial was designed to determine if treatment with trastuzumab emtansine (T-DM1) caused less toxicity than paclitaxel plus (TH) and yielded clinically acceptable invasive disease-free survival (iDFS) among patients stage I human epidermal growth factor receptor 2-positive (HER2+) breast cancer (BC).Patients centrally confirmed HER2+ BC were randomly assigned 3:1 T-DM1 or TH received 3.6 mg/kg IV every 3 weeks for 17 cycles T 80 mg/m2 H once week × 12 (4 load →2 mg/kg), followed by...
Abstract Objective To assess body image concerns among young women following a breast cancer diagnosis. Methods A total of 419 with recently diagnosed stage 0–III were surveyed enrollment as part prospective cohort study age 40 or younger at Body was assessed using three items from the psycho‐social scale Cancer Rehabilitation Evaluation System (CARES). CARES scores range 0 to 4, higher indicative greater concerns. Mean calculated and compared between treatment groups t‐tests analysis...
<h3>Importance</h3> Young women with breast cancer are increasingly choosing bilateral mastectomy (BM), yet little is known about short-term and long-term physical psychosocial well-being following surgery in this population. <h3>Objective</h3> To evaluate the differential associations of quality life (QOL) outcomes from 1 to 5 years diagnosis. <h3>Design, Setting, Participants</h3> Cohort study <h3>Setting</h3> Multicenter, including academic community hospitals North America...
BRCA testing is recommended for young women diagnosed as having breast cancer, but little known about decisions surrounding and how results may influence treatment in patients.To describe the use of to evaluate concerns genetic risk information affect subsequent with cancer.Cross-sectional analysis data collected following opening study accrual from October 10, 2006, through December 31, 2014, part Helping Ourselves, Others: Young Women's Breast Cancer Study, an ongoing prospective cohort...
BACKGROUND Sexual dysfunction is a known complication of adjuvant therapy for breast cancer and an important determinant quality life. However, few studies have explored how treatment other factors affect sexual functioning in young survivors. METHODS Four hundred sixty‐one premenopausal women with stage 0 through III were surveyed average 1 year after diagnosis as part prospective cohort study who aged ≤40 years at diagnosis. interest assessed using the Cancer Rehabilitation Evaluation...
Background Fear of cancer recurrence (FCR) is more intense in younger women. Because FCR a powerful determinant quality life, identifying those at risk for persistently elevated can inform timing interventions. Methods A total 965 women with stage 0 to III breast enrolled the Young Women's Breast Cancer Study, prospective cohort diagnosed age ≤40 years, completed 3‐item Lasry Recurrence Index. Group‐based trajectory modeling was used classify distinct patterns from baseline through 5 years...
Aberrant promoter methylation and genomic instability occur frequently during colorectal cancer development. CpG island methylator phenotype (CIMP) has been shown to associate with microsatellite instability, BRAF mutation is often found in the right-side colon. Nevertheless, relative importance of CIMP chromosomal (CIN) for tumorigenesis yet be thoroughly investigated sporadic cancers.We determined 161 primary cancers 66 matched normal mucosae using a quantitative bisulfite/PCR/ligase...
Abstract Objective Using a large prospective cohort of women age 40 or younger diagnosed with breast cancer, we examined the relationship between perceived partner support and anxiety. Methods Six hundred seventy‐five young cancer Stages I–III, median 36, completed self‐report baseline questionnaire. Perceived was assessed using items extracted from marital subscale Cancer Rehabilitation Evaluation System; generalized social Medical Outcomes Study–Social Support Survey. Anxiety measured...
The 21-gene recurrence score (RS) assay is prognostic among women with early-stage estrogen receptor-positive (ER+) and human epidermal growth factor receptor 2-negative (HER2-) breast cancer used to inform recommendations for chemotherapy. Women ≤ 40 years of age represent a minority patients studied using gene expression profiles.The Young Women's Breast Cancer Study prospective cohort diagnosed at enrolled between 2006 2016 (N = 1,302). We identified stage I-III ER+/HER2- cancer. RS was...
Abstract De-escalating adjuvant therapy following pathologic complete response (pCR) to an abbreviated neoadjuvant regimen in human epidermal growth factor receptor 2-positive (HER2+) breast cancer is the focus of international research efforts. However, feasibility this approach and its appeal patients providers had not been formally investigated. We aimed assess adherence de-escalated antibody doublet (trastuzumab pertuzumab [HP], without chemotherapy) among with pCR paclitaxel/HP (THP)....
Among women diagnosed with primary breast cancer (BC) at or younger than age 40 years, prior data suggest that their risk of a second BC (SPBC) is higher who are older when they develop first BC.
ABSTRACT Purpose This study aimed to understand the reasons for high risk of job loss previously identified among foreign‐born Chinese breast cancer survivors in United States Qualitative interviews were conducted explore challenges leading during/after treatment and help identify potential interventions promote retention re‐employment. Patients Methods The research team semi‐structured with New York City. A total 12 participants, enrolled Breast Cancer Workforce study, interviewed between...
Many young women are at increased risk for premature menopause following adjuvant treatment breast cancer. These must deal with consequences of menopause, including loss fertility and physiologic symptoms such as night sweats, hot flashes, vaginal dryness, weight gain. can be particularly distressing adversely affect both health-related psychosocial quality life (QOL). While there a wide range pharmacologic non-pharmacologic interventions available to help these in turn, improve QOL, is...
Young breast cancer survivors in Mexico face distinct psychosocial challenges that have not been characterized. This study aims to describe the needs of young at 5 or more years survivorship, identifying areas focus for early interventions.
Abstract Background. Adherence to adjuvant endocrine therapy (ET) influences breast cancer survival. Because ET side effects are frequently cited as reasons for nonadherence, understanding how perceptions and motivations in relation associated with symptom attribution can help promote timely management. Materials Methods. Participants were 2,086 survivors recruited through the Army of Women registry who current tamoxifen or aromatase inhibitor (AI) users. reported whether they bothered by...