Cynthia Villarreal‐Garza
A5031392838- BRCA gene mutations in cancer
- Breast Cancer Treatment Studies
- Global Cancer Incidence and Screening
- Cancer Risks and Factors
- Cancer survivorship and care
- Cancer Genomics and Diagnostics
- Economic and Financial Impacts of Cancer
- Advanced Breast Cancer Therapies
- Cancer Treatment and Pharmacology
- Nutrition, Genetics, and Disease
- Reproductive Biology and Fertility
- HER2/EGFR in Cancer Research
- Women's cancer prevention and management
- Multiple and Secondary Primary Cancers
- Cancer Diagnosis and Treatment
- Advances in Oncology and Radiotherapy
- Patient-Provider Communication in Healthcare
- Family Support in Illness
- DNA Repair Mechanisms
- Health Systems, Economic Evaluations, Quality of Life
- Lung Cancer Treatments and Mutations
- Breast Lesions and Carcinomas
- Lung Cancer Research Studies
- Global Public Health Policies and Epidemiology
- PARP inhibition in cancer therapy
Tecnológico de Monterrey
2016-2025
Hospital Zambrano Hellion
2016-2025
Instituto Nacional de las Mujeres
2017-2024
Instituto Nacional de Cancerología
2015-2024
Universidad Nacional Autónoma de México
2009-2020
Hospital de Clínicas de Porto Alegre
2019
Instituto Nacional de Enfermedades Neoplásicas
2018-2019
Consejo Nacional de Humanidades, Ciencias y Tecnologías
2018-2019
Queen's University
2019
Global Cancer Institute
2019
BACKGROUND: Triple-negative breast cancer (TNBC) is defined as that negative for estrogen receptor, progesterone and human epidermal growth factor receptor 2. TNBC represents 15% of all invasive cancers, but some studies have suggested its prevalence differs between races. To the authors' knowledge, no previous determined risk factors among Hispanic women. METHODS: The authors identified 2074 women with who attended National Cancer Institute in Mexico City from 1998 to 2008. All...
Severe burns induce pathophysiologic problems, among them catabolism of lean mass, leading to protracted hospitalization and prolonged recovery. Oxandrolone is an anabolic agent shown decrease mass improve wound healing in the severely burned patients. We enrolled 81 adult subjects with 20% 60% TBSA a multicenter trial testing effects oxandrolone on length hospital stay. Subjects were randomized between 10 mg every 12 hours or placebo. The study was stopped halfway through projected...
Abstract Background. Breast cancer (BC) is the leading cause of malignancy-related deaths among women aged ≤45 years. There are unexplored and uncertain issues for BC in this particular group Latin America. The aim study to evaluate incidence mortality young related clinicopathological survivorship aspects region. Materials Methods. Data were obtained from Globocan 2008 International Agency Research on Cancer's Cancer Incidence Five Continents series plus databases. We requested...
Young women with germline BRCA mutations have unique reproductive challenges. Pregnancy after breast cancer does not increase the risk of recurrence; however, very limited data are available in patients mutations. This study investigated impact pregnancy on outcomes mutations.This is an international, multicenter, hospital-based, retrospective cohort study. Eligible were diagnosed between January 2000 and December 2012 invasive early at age ≤ 40 years harbored deleterious Primary end points...
Importance Young women with breast cancer who have germline pathogenic variants in BRCA1 or BRCA2 face unique challenges regarding fertility. Previous studies demonstrating the feasibility and safety of pregnancy survivors included limited data BRCA carriers. Objective To investigate cumulative incidence disease-free survival young are Design, Setting, Participants International, multicenter, hospital-based, retrospective cohort study conducted at 78 participating centers worldwide. The...
Brain metastases occur in 30-50% of Non-small cell lung cancer (NSCLC) patients and confer a worse prognosis quality life. These are usually treated with Whole-brain radiotherapy (WBRT) followed by systemic therapy. Few studies have evaluated the role chemoradiotherapy to primary tumor after WBRT as definitive treatment management these patients.We reviewed outcome 30 NSCLC brain metastasis at diagnosis without evidence other metastatic sites. Patients were induction chemotherapy paclitaxel...
We examined the impact of diabetes and hyperglycemia on cancer-specific survival patients with metastatic or recurrent breast cancer (BC). performed a retrospective analysis 265 advanced BC receiving palliative chemotherapy. BC-specific mortality was compared for diabetic nondiabetic as well that presented during treatment. No difference observed between in terms overall (OS). A OS who had hyperglycemia. The greater proper metabolic control than risk death higher mean glucose levels >130...
BACKGROUND Frequent recurrent mutations in the breast and ovarian cancer susceptibility ( BRCA ) genes BRCA1 BRCA2 among Hispanics, including a large rearrangement Mexican founder mutation exon 9‐12 deletion [ex9‐12del]), suggest that an ancestry‐informed ‐testing strategy could reduce disparities promote prevention by enabling economic screening for hereditary Mexico. METHODS In multistage approach, 188 patients with who were unselected family history (92 96 cancer) screened using Hispanic...
Several breast cancer (BC) trials have adopted pathological complete response (pCR) as a surrogate marker of long-term treatment efficacy. In patients with luminal subtype, pCR seems less important for outcome prediction. BC is heterogeneous disease, which evident in residual tumors after neoadjuvant-chemotherapy (NAC). This study evaluates changes Ki67 relation to disease-free survival (DFS) and overall (OS) without pCR.Four hundred thirty-five stage IIA-IIIC standard NAC anthracycline...
Purpose One half of the Mexican population lacks comprehensive health care coverage. In 2003, a reform to General Health Law was approved that led creation System Social Protection in and made universal coverage mandatory. The main innovation this Seguro Popular, which provided for breast cancer. Here we report outcomes women with cancer treated at center Mexico under Popular. Materials Methods This retrospective cohort study included all patients Instituto Nacional de Cancerología City...
Abstract Background Breast cancer (BC) in women aged ≤40 years carrying germline pathogenetic variants (PVs) BRCA1/2 genes is infrequent but often associated with aggressive features. Human epidermal growth factor receptor 2 (HER2)‐low‐expressing BC has recently emerged as a novel therapeutic target not been characterized this rare patient subset. Methods Women newly diagnosed early‐stage HER2‐negative (HER2‐0 and HER2‐low) PVs from 78 health care centers worldwide were retrospectively...