A5055089156- Global Cancer Incidence and Screening
- BRCA gene mutations in cancer
- Cervical Cancer and HPV Research
- Breast Cancer Treatment Studies
- Helicobacter pylori-related gastroenterology studies
- Gastric Cancer Management and Outcomes
- Cancer survivorship and care
- Economic and Financial Impacts of Cancer
- Health Systems, Economic Evaluations, Quality of Life
- Endometrial and Cervical Cancer Treatments
- Global Public Health Policies and Epidemiology
- Cancer Genomics and Diagnostics
- Cancer Risks and Factors
- Ovarian cancer diagnosis and treatment
- Nutrition, Genetics, and Disease
- Viral-associated cancers and disorders
- Lymphoma Diagnosis and Treatment
- Colorectal Cancer Screening and Detection
- Colorectal and Anal Carcinomas
- HIV/AIDS Research and Interventions
- Women's cancer prevention and management
- Breast Lesions and Carcinomas
- Family Support in Illness
- Public Health in Brazil
- Advanced Breast Cancer Therapies
Instituto Nacional de Cancerología
2016-2025
Universidad Nacional Autónoma de México
2015-2025
Instituto Nacional de Cancerología
2015-2024
Instituto Nacional de las Mujeres
2017-2022
Tecnológico de Monterrey
2017-2020
Hospital Zambrano Hellion
2019-2020
Roche (Switzerland)
2017-2019
Bristol-Myers Squibb (Germany)
2003-2019
Pfizer (United Kingdom)
2019
Bayer (United States)
2019
When breast cancer is detected and treated early, the chances of survival are very high. However, women in many settings face complex barriers to early detection, including social, economic, geographic, other interrelated factors, which can limit their access timely, affordable, effective health care services. Previously, Breast Health Global Initiative (BHGI) developed resource‐stratified guidelines for detection diagnosis cancer. In this consensus article from sixth BHGI Summit held...
Chromosomal instability as manifested by increases in aneuploidy and structural chromosome aberrations is believed to play a critical role the intermediate late stages development of cervical malignancies. The current study was designed determine tetraploidy formation ascertain occurrence these alterations during earlier carcinogenesis. Cervical cell samples, with diagnoses ranging from Normal high-grade lesions, (HSIL) were obtained 143 women evaluated for chromosomal using dual-probe...
BACKGROUND: Triple-negative breast cancer (TNBC) is defined as that negative for estrogen receptor, progesterone and human epidermal growth factor receptor 2. TNBC represents 15% of all invasive cancers, but some studies have suggested its prevalence differs between races. To the authors' knowledge, no previous determined risk factors among Hispanic women. METHODS: The authors identified 2074 women with who attended National Cancer Institute in Mexico City from 1998 to 2008. All...
Abstract Background. Breast cancer (BC) is the leading cause of malignancy-related deaths among women aged ≤45 years. There are unexplored and uncertain issues for BC in this particular group Latin America. The aim study to evaluate incidence mortality young related clinicopathological survivorship aspects region. Materials Methods. Data were obtained from Globocan 2008 International Agency Research on Cancer's Cancer Incidence Five Continents series plus databases. We requested...
Importance Young women with breast cancer who have germline pathogenic variants in BRCA1 or BRCA2 face unique challenges regarding fertility. Previous studies demonstrating the feasibility and safety of pregnancy survivors included limited data BRCA carriers. Objective To investigate cumulative incidence disease-free survival young are Design, Setting, Participants International, multicenter, hospital-based, retrospective cohort study conducted at 78 participating centers worldwide. The...
Abstract Gastric cancer (GC) incidence has not declined in Mexico. We assessed whether the intake of capsaicin (CAP), pungent compound chili peppers, increases risk GC independently H. pylori positivity (Hp). From 1994 to 1996, a hospital‐based case‐control study was performed 3 areas Mexico; 234 cases and 468 matched controls were enrolled their diet other characteristics inquired. Chili pepper queried by interview CAP content chilies determined separate analysis gas chromatography estimate...
Abstract Helicobacter pylori causes gastric adenocarcinoma; whether treatment of H. infection prevents this cancer remains unknown. In a randomized, double-blind, placebo-controlled trial eradication, we determined for decreases risk, using preneoplastic conditions as surrogate markers. A total 248 healthy volunteers (age >40 years) randomly received (omeprazole, amoxicillin, clarythromycin; n = 122) or matched placebo (n 126) 1 week. Endoscopy was performed at baseline and 6 weeks...
We examined the impact of diabetes and hyperglycemia on cancer-specific survival patients with metastatic or recurrent breast cancer (BC). performed a retrospective analysis 265 advanced BC receiving palliative chemotherapy. BC-specific mortality was compared for diabetic nondiabetic as well that presented during treatment. No difference observed between in terms overall (OS). A OS who had hyperglycemia. The greater proper metabolic control than risk death higher mean glucose levels >130...
BACKGROUND Frequent recurrent mutations in the breast and ovarian cancer susceptibility ( BRCA ) genes BRCA1 BRCA2 among Hispanics, including a large rearrangement Mexican founder mutation exon 9‐12 deletion [ex9‐12del]), suggest that an ancestry‐informed ‐testing strategy could reduce disparities promote prevention by enabling economic screening for hereditary Mexico. METHODS In multistage approach, 188 patients with who were unselected family history (92 96 cancer) screened using Hispanic...
Several breast cancer (BC) trials have adopted pathological complete response (pCR) as a surrogate marker of long-term treatment efficacy. In patients with luminal subtype, pCR seems less important for outcome prediction. BC is heterogeneous disease, which evident in residual tumors after neoadjuvant-chemotherapy (NAC). This study evaluates changes Ki67 relation to disease-free survival (DFS) and overall (OS) without pCR.Four hundred thirty-five stage IIA-IIIC standard NAC anthracycline...
Purpose One half of the Mexican population lacks comprehensive health care coverage. In 2003, a reform to General Health Law was approved that led creation System Social Protection in and made universal coverage mandatory. The main innovation this Seguro Popular, which provided for breast cancer. Here we report outcomes women with cancer treated at center Mexico under Popular. Materials Methods This retrospective cohort study included all patients Instituto Nacional de Cancerología City...
Preventable risk factors are responsible of at least 40% cases and almost 45% all cancer deaths worldwide. Cancer is already the leading cause death in half Latin American Caribbean countries constituting a public health problem. Cost-effective measures to reduce exposures through primary prevention screening certain types cancers critical fight against but need be tailored local needs scenarios. The America (LAC) Code Against Cancer, 1st edition, consists 17 evidence-based recommendations...
Background. Helicobacter pylori recently was identified as a risk factor for gastric cancer. Its association with preneoplastic conditions of the stomach, however, is undocumented. Methods. Gastric biopsy specimens from 245 symptomatic patients were examined neoplastic and lesions H. infection. The sera 183 subjects tested by enzyme-linked immunosorbent assay (ELISA) anti-H. immunoglobulin G. Results. Histologic infection, usually accompanied acute chronic gastritis, found in 85.7% patients....