A5088947747- Cervical Cancer and HPV Research
- Global Cancer Incidence and Screening
- Hepatitis B Virus Studies
- Childhood Cancer Survivors' Quality of Life
- Biosensors and Analytical Detection
- Public Health Policies and Education
- Health Systems, Economic Evaluations, Quality of Life
- Global Maternal and Child Health
- Global Public Health Policies and Epidemiology
- Women's cancer prevention and management
- Genital Health and Disease
- Colorectal Cancer Screening and Detection
- SARS-CoV-2 detection and testing
- Global Health and Surgery
- Advances in Oncology and Radiotherapy
- SARS-CoV-2 and COVID-19 Research
- Adolescent Sexual and Reproductive Health
- COVID-19 Clinical Research Studies
- Ethics in Clinical Research
- COVID-19 and Mental Health
- Viral Infections and Outbreaks Research
- AI in cancer detection
- Reproductive Health and Technologies
- Long-Term Effects of COVID-19
- Food Waste Reduction and Sustainability
World Health Organization Regional Office for the Americas
2021-2024
Clinica Universidad de Navarra
2024
McMaster University
2023
Pan American Health Organization (Cuba)
2023
Cleveland Clinic
2016-2017
The Ohio State University Wexner Medical Center
2017
Medical College of Wisconsin
2017
University of Southern California
2017
National Institutes of Health
2017
Medical Care Development International
2016
Cervical cancer incidence and mortality rates are significantly higher in low- middle-income countries compared with the United States other developed countries. This disparity is caused by decreased access to screening, often coupled low numbers of trained providers offering prevention treatment services. However, similar disparities also found underserved areas States, such as Texas-Mexico border, where cervical 30% than rest Texas. To address these issues, we have adopted Project ECHO...
Preventable risk factors are responsible of at least 40% cases and almost 45% all cancer deaths worldwide. Cancer is already the leading cause death in half Latin American Caribbean countries constituting a public health problem. Cost-effective measures to reduce exposures through primary prevention screening certain types cancers critical fight against but need be tailored local needs scenarios. The America (LAC) Code Against Cancer, 1st edition, consists 17 evidence-based recommendations...
Cervical cancer is a public health emergency in low- and middle-income countries where resource limitations hamper standard-of-care prevention strategies. The high-resolution endomicroscope (HRME) low-cost, point-of-care device with which care providers can image the nuclear morphology of cervical lesions. Here, we propose deep learning framework to diagnose intraepithelial neoplasia grade 2 or more severe from HRME images. proposed multi-task convolutional neural network uses segmentation...
Abstract There is a gap in the understanding of barriers to cancer screening participation and complying with downstream management Community Latin American Caribbean states (CELAC). Our study aimed assess across pathway from health system perspective, interventions place improve CELAC. A standardized tool was used collect information on through engagement authorities 27 member Barriers were organized framework adapted Tanahashi conceptual model consisted following dimensions: availability...
Cervical cancer is the leading cause of death among women in El Salvador. Utilizing data from Cancer Prevention Salvador (CAPE) demonstration project, we assessed health and economic impact HPV-based screening two different algorithms for management who test HPV-positive, relative to existing Pap-based screening. We calibrated a mathematical model cervical epidemiologic compared three aged 30-65 years: (i) HPV every 5 years followed by referral colposcopy HPV-positive (Colposcopy Management...
In a cross-sectional study carried out in El Salvador between February 2016 and July 2017, self-sampling human papillomavirus (HPV) testing was found to be highly acceptable among 2019 women who had not attended cervical cancer screening at least 3 years. Within this population, HPV positivity rates differed according age, marital status, number of children, lifetime sexual partners. The proportion tested positive or were diagnosed with intraepithelial neoplasia grade 2 (CIN2) more severe...
Cervical cancer disproportionally affects women in low- and middle-income countries, part due to the difficulty of implementing existing cervical screening diagnostic technologies low-resource settings. Single-board computers offer a low-cost alternative provide computational support for automated point-of-care technologies. Here we demonstrate two new devices prevention that use single-board computer: 1) imaging system real-time detection precancer 2) reader interpretation lateral...
Cervical cancer is a leading cause of death for women in low-resource settings. The World Health Organization recommends that cervical screening programs incorporate HPV DNA testing, but available tests are expensive, require laboratory infrastructure, and cannot be performed at the point-of-care. We developed two-dimensional paper network (2DPN), hybrid-capture, signal amplification assay point-of-care sample preparation protocol to detect high-risk from exfoliated cells within an hour....
The Cervical Cancer Prevention in El Salvador is a demonstration project to introduce lower-cost human papillomavirus (HPV)-DNA test into public sector project. Started October 2012, consists of 3 phases and will ultimately screen 30,000 women. Results phase 2 the are presented. objective this was compare colposcopy noncolposcopy-based management for HPV-positive women.In 2, total 8,050 women, aged 30 49 years, were screened; 6,761 provided both self- provider-collected specimens 1,289 only...
Abstract Objective To assess the cost‐effectiveness of HPV‐based screening and management algorithms for HPV‐positive women in phase 2 Cervical Cancer Prevention El Salvador (CAPE) demonstration, relative to status quo Pap‐based screening. Methods Data from CAPE demonstration (n=8000 women) were used inform a mathematical model HPV infection cervical cancer. The was project lifetime health economic outcomes testing every 5 years (age 30–65 years), with referral colposcopy women; immediate...
The Global Initiative for Childhood Cancer (GICC) aims to increase the cure rate children with cancer globally by improving healthcare access and quality. Pan American Health Organization (PAHO), St. Jude Children’s Research Hospital (St. Jude), collaborators have joined efforts improve outcomes of in Latin America Caribbean (LAC) using Cure<italic>All</italic> framework. In this article, we describe process developing regional resources aimed at accelerating GICC implementation LAC. March...
Abstract Cervical cancer is a leading cause of death among women in the developing world. Conventional cytology‐based cervical screening programs have been largely ineffectual at reducing burden low‐resource settings. In response, alternative strategies tested, such as visual inspection with acetic acid (VIA) and human papillomavirus (HPV) DNA‐based testing. This manuscript reviews literature addressing programmatic approaches to implementing settings, highlighting challenges, barriers,...
Cervical cancer is the third most commonly occurring among women and fourth leading cause of cancer-related deaths in worldwide, with more than 85 % these cases developing countries. These global disparities reflect differences cervical screening rates between high-income medium- low-income At 19 %, El Salvador has lowest reported coverage all Latin American The purpose this study to identify factors affecting public sector HPV DNA-based participation Salvador. This was nested within a...
In Brief Objective a primary human papillomavirus (HPV) screening program, we compared the 6-month follow-up among colposcopy and noncolposcopy-based management strategies for screen-positive women. Materials Methods Women aged 30 to 49 years were screened with HPV DNA tests using both self-collection provider collection of samples. testing positive received either (1) (CM) consisting per local guidelines or (2) screen-and-treat (ST) visual inspection acetic acid determine cryotherapy...