A5024875322- Childhood Cancer Survivors' Quality of Life
- Acute Lymphoblastic Leukemia research
- Global Cancer Incidence and Screening
- Child and Adolescent Health
- Palliative Care and End-of-Life Issues
- Advances in Oncology and Radiotherapy
- Ocular Oncology and Treatments
- COVID-19 and healthcare impacts
- Ethics and Legal Issues in Pediatric Healthcare
- Health Systems, Economic Evaluations, Quality of Life
- Family and Patient Care in Intensive Care Units
- Interprofessional Education and Collaboration
- COVID-19 Clinical Research Studies
- Family Support in Illness
- Lymphoma Diagnosis and Treatment
- Neonatal Respiratory Health Research
- Nonmelanoma Skin Cancer Studies
- Neuroblastoma Research and Treatments
- Renal and related cancers
- Glioma Diagnosis and Treatment
- PARP inhibition in cancer therapy
- Infant Development and Preterm Care
- Sarcoma Diagnosis and Treatment
- Patient-Provider Communication in Healthcare
- Digital Storytelling and Education
Hospital Nacional de Niños Bloom
2016-2025
World Health Organization Regional Office for the Americas
2022-2025
McMaster University
2023
St. Jude Children's Research Hospital
2017-2020
Harvard University
2017
Dana-Farber Cancer Institute
2017
Since 2000, centers across Central America have shared treatment guidelines for Wilms tumor, using histology (anaplasia present or absent) and tumor stage to stratify patients into low-, intermediate-, high-risk groups. Weekly virtual board meetings involving local international experts were held ensure consistent assignments. We analyzed data from 367 children with unilateral tumors treated per these guidelines. Five-year abandonment-sensitive event-free overall survival estimates were: low...
Treatment abandonment because of enucleation refusal is a limitation improving outcomes for children with retinoblastoma in countries limited resources. Furthermore, many present buphthalmos and high risk globe rupture during enucleation. To address these unique circumstances, the AHOPCA II protocol introduced neoadjuvant chemotherapy delayed enucleation.Patients advanced unilateral intraocular disease (International Retinoblastoma Staging System [IRSS] stage I) were considered upfront Those...
Background Despite increasing global attention to non-communicable diseases (NCDs) and their incorporation into universal health coverage (UHC), the factors that determine whether how NCDs are prioritized in national agendas integrated systems remain poorly understood. Childhood cancer is a leading cause of death children aged 0–14 years worldwide. We investigated political, social, economic influence system priority-setting on childhood care range low- middle-income countries (LMIC)....
BACKGROUND Although previous studies have examined the cost of treating individual childhood cancers in low‐income and middle‐income countries, to authors' knowledge none has overall cost‐effectiveness operating a cancer treatment center. Herein, authors sources financing pediatric unit Hospital Nacional de Ninos Benjamin Bloom El Salvador, make estimates cost‐effectiveness. METHODS Administrative data regarding costs volumes inputs were obtained for 2016 unit. Similar volume shared medical...
Global variations in the incidence of pediatric cancers have been described; however, causes such differences are not known. We investigated relationship between embryonal tumors and human development index on a global scale. Increasing neuroblastoma correlates significantly with an increasing development, greater among countries high socioeconomic apparent contrast to retinoblastoma. While more data needed corroborate this observation, our findings suggest new avenues for etiological...
The Global Initiative for Childhood Cancer (GICC) aims to increase the cure rate children with cancer globally by improving healthcare access and quality. Pan American Health Organization (PAHO), St. Jude Children’s Research Hospital (St. Jude), collaborators have joined efforts improve outcomes of in Latin America Caribbean (LAC) using Cure<italic>All</italic> framework. In this article, we describe process developing regional resources aimed at accelerating GICC implementation LAC. March...
Working with PAHO/WHO to prioritize childhood cancer in the context of systems strengthening is central St. Jude Children's Research Hospital (SJCRH)'s role as WHO Collaborating Centre for Childhood Cancer. This manuscript focuses on how SJCRH and have partnered apply C5 (Country Collaboration Cancer Control) define implement priority actions regionally, Ministry programs cancer, while implementing Global Initiative since 2018. Using C5, a tool developed by SJCRH, co-hosted regional/national...
Abstract Background Treating B–non‐Hodgkin lymphoma (B‐NHL) in lower‐income countries is challenging because of imprecise diagnosis, the increased risk fatal toxicity associated with advanced disease at presentation, and limited supportive care. Procedure Central American patients newly diagnosed stage I or II B‐NHL received a modified Berlin–Frankfurt–Münster (BFM) regimen including prephase (prednisone, cyclophosphamide) followed by A/B/A courses (A: cytarabine, dexamethasone, etoposide,...
This report describes the status of childhood cancer control initiatives in Latin America and Caribbean (LAC). Progress between 2017 2023 is measured using outcome indicators from Pan American Health Organization (PAHO) logic model aligned with World Global Initiative for Childhood Cancer (GICC). also advances, barriers, facilitators implementation GICC at Regional level. Methods used this encompassed a comprehensive approach, incorporating literature review, interviews, surveys, Delphi...
To describe the development of educational materials for parents and other caregivers children with cancer, which utilized a culturally sensitive approach to reduce acceptance barriers palliative care (PC).The Pan American Health Organization (PAHO), St. Jude Children's Research Hospital, partners in Latin America Caribbean collaborated three-phase project, beginning needs assessment survey cancer Peru. Based on this finding, an interdisciplinary team pediatric PC experts developed content...
The ongoing coronavirus 2019 disease (COVID-19) pandemic strained medical systems worldwide. We report on the impact pediatric oncology care in Latin American (LATAM) during its first year.Four cross-sectional surveys were electronically distributed among onco-hematologists April/June/October 2020, and April/2021 through Society of Pediatric Oncology (SLAOP) email list St Jude Global regional partners.Four hundred fifty-three from 20 countries responded to survey, with subsequent response...
Abstract Background Quality cancer care depends on interdisciplinary communication. This study explored the communication practices of clinicians, types healthcare services for which they engage in collaboration, and association between perceived quality care, as well job satisfaction. Methods We conducted a survey clinicians from centers Guatemala, Honduras, Panama, El Salvador, Haiti. The included 68 items including previously validated tools novel questions. Results Total 174 completed...
To highlight the objectives, achievements, challenges, and next steps for World Health Organization's Global Initiative Childhood Cancer (GICC) framework, a project designed to improve psychosocial care (PSC) in pediatric cancer centers across Latin America Caribbean (LAC).The was launched Peru, first GICC focal country, November 2020. The diagnosis phase included survey semistructured interview with health professionals assess PSC practices institutions, needs assessment caregivers. In...
High-risk Hodgkin lymphoma (HRHL) in children is curable with combined modality therapy. The Association of Pediatric Hematology-Oncology Central America (AHOPCA) a consortium cancer centers from America. In 2004, AHOPCA implemented guideline short course chemotherapy (mStanfordV), strict diagnostics, and radiation guidelines, aimed at reducing abandonment improving outcomes.Newly diagnosed less than 18 years age high-risk HL (Ann Arbor stages: IIB, IIIB, IV) were staged chest radiography...
Background Interdisciplinary teamwork supports high‐quality cancer care and effective utilization of limited resources. This study purposed to examine the value, structure, process, effectiveness interdisciplinary (IDC) among pediatric oncology providers in low‐income middle‐income countries Central America Caribbean. Methods A cross‐sectional survey was disseminated at 5 centers participating Pediatric Hematology‐Oncology Association America. The included previously validated items novel...
Abstract 57 Background: Patients with WT in AHOPCA present late large abdominal masses, poor clinical condition. This analysis focuses on treatment failure. Methods: Between 2012 and 2015, 182 evaluable patients were diagnosed unilateral WT. staged ultrasound/computed tomography thorax radiograph/CT. Therapy was adapted from National Wilms Tumor Study-5 except for masses and/or severe malnutrition who received preoperative doxorubicin, vincristine, actinomycin-D 4 to 6 weeks. Treatment...
This article aims to describe the activities conducted by National Childhood Cancer Plan Working Group support development of national childhood cancer plans in Latin America and Caribbean period 2019-2022, present stage plan development. The were supported Pan American Health Organization St. Jude Children's Research Hospital, which is World (WHO) Collaborating Centre for Cancer. Year after year, workshops developed with mobilized key stakeholders: pediatric oncologists, representatives...