A5011797345- Ocular Oncology and Treatments
- Multiple Myeloma Research and Treatments
- Lung Cancer Treatments and Mutations
- Cancer Genomics and Diagnostics
- COVID-19 Clinical Research Studies
- Glioma Diagnosis and Treatment
- Palliative Care and End-of-Life Issues
- Pain Management and Opioid Use
- Cancer Immunotherapy and Biomarkers
- Long-Term Effects of COVID-19
- Economic and Financial Impacts of Cancer
- Lymphoma Diagnosis and Treatment
- Acute Myeloid Leukemia Research
- Sepsis Diagnosis and Treatment
- Intestinal and Peritoneal Adhesions
- Retinopathy of Prematurity Studies
- Pediatric Pain Management Techniques
- Cannabis and Cannabinoid Research
- Cutaneous Melanoma Detection and Management
- Colorectal Cancer Treatments and Studies
- Chronic Lymphocytic Leukemia Research
- Nausea and vomiting management
- HIV/AIDS Research and Interventions
- Opioid Use Disorder Treatment
- Patient Dignity and Privacy
Zealand University Hospital
2024
Roswell Park Comprehensive Cancer Center
2018-2023
Eye Institute of Utah
2022-2023
University of Utah
2019-2023
University at Buffalo, State University of New York
1981-2022
University of Miami
2015-2022
Jacobs Institute
2020
Johns Hopkins University
2017-2018
Sidney Kimmel Comprehensive Cancer Center
2017-2018
University of Rochester Medical Center
2010-2013
Immune checkpoint inhibitors (ICIs) are the standard of care for treatment several cancers. While these immunotherapies have improved patient outcomes in many clinical settings, they bring accompanying risks toxicity, specifically immune-related adverse events (irAEs). There is a need clear, effective guidelines management irAEs during ICI treatment, motivating Society Immunotherapy Cancer (SITC) to convene an expert panel develop practice guideline. The discussed recognition and single...
In recent years, the NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) for Adult Cancer Pain have undergone substantial revisions focusing on appropriate and safe prescription of opioid analgesics, optimization nonopioid analgesics adjuvant medications, integration nonpharmacologic methods cancer pain management. This selection highlights some these changes, covering topics management adult including pharmacologic interventions, treatment specific syndromes. The complete...
Hydroxychloroquine has been touted as a potential COVID-19 treatment. Tocilizumab, an inhibitor of IL-6, also proposed treatment critically ill patients. In this retrospective observational cohort study drawn from electronic health records we sought to describe the association between mortality and hydroxychloroquine or tocilizumab therapy among hospitalized Patients were at 13-hospital network spanning New Jersey USA March 1, 2020 April 22, with positive polymerase chain reaction results...
Abstract Background Hydroxychloroquine has been touted as a COVID-19 treatment. Tocilizumab, an inhibitor of IL-6, proposed treatment critically ill patients. Objective To describe the association between mortality and hydroxychloroquine or tocilizumab therapy among hospitalized Design Retrospective observational cohort study electronic health records Setting: 13-hospital network spanning state New Jersey. Participants Patients March 1, 2020 April 22, with positive polymerase chain reaction...
Abstract Background Hydroxychloroquine has not been associated with improved survival among hospitalized COVID-19 patients in the majority of observational studies and similarly was identified as an effective prophylaxis following exposure a prospective randomized trial. We aimed to explore role hydroxychloroquine therapy mildly symptomatic diagnosed outpatient setting. Methods examined association between subsequent progression disease non-hospitalized documented SARS-CoV-2 infection. The...
ABSTRACT Introduction COVID-19 disproportionately affects those with comorbidities and the elderly. Hypertension is most common pre-existing condition amongst patients. Upregulation of renin-angiotensin-aldosterone system (RAAS) in hypertensive patients may promote inflammation ensuing cytokine storm COVID-19. It unknown whether RAAS inhibition ACE1 inhibitors or angiotensin-receptor blockers (ARB) can be harmful beneficial. Methods Within Hackensack Meridian Health network, largest...
The purpose of this study was to evaluate the potential collective opportunities and challenges transforming real-world data (RWD) evidence for clinical effectiveness by focusing on aligning analytic definitions oncology end points. Patients treated with a qualifying therapy advanced non-small cell lung cancer in frontline setting meeting broad eligibility criteria were included reflect population. Although trend toward improved outcomes patients receiving PD-(L)1 over standard chemotherapy...
Foot and ankle operations are being performed with greater frequency as outpatient procedures. Although the surgical procedure remains same whether operation is done in an inpatient or setting, anesthesia postoperative analgesia greatly affected when patients must be discharged soon after their operation. We have evaluated a regional anesthetic technique which blocks sciatic nerve popliteal fossa saphenous block at knee. This was sole for both immediate period. appears to several advantages:...
In prior work, Friends of Cancer Research convened multiple data partners to establish standardized definitions for oncology real-world end points derived from electronic health records (EHRs) and claims data. Here, we assessed the performance overall survival (rwOS) sets sourced EHRs by evaluating ability point reflect expected differences a previous randomized controlled trial across five sources, after applying inclusion/exclusion criteria. The KEYNOTE-189 clinical protocol platinum...
Daratumumab (dara)-based triplet therapies are commonly employed in the second- (2L) and third-line (3L) settings relapsed/refractory multiple myeloma (RRMM), usually combination with dexamethasone either bortezomib (dara-Vd), carfilzomib (dara-Kd), or pomalidomide (dara-Pd). We performed a real-world (rw) analysis to directly compare these regimens for first time. This was an observational, retrospective cohort study utilizing COTA's rw database of patients MM who have initiated 2L 3L...
Abstract Aims Glioblastoma patients have a dismal prognosis, due to inevitable tumour recurrence and respond poorly immunotherapy. Tumour‐associated microglia/macrophages (TAMs) dominate the glioblastoma microenvironment been implicated in progression immune evasion. Early recurrent glioblastomas contain focal reactive regions with occasional fibrosis, chronic inflammation, TAMs cells. Surgical specimens from these tumours are rare provide crucial insights into biology. This study aimed...
Purpose: To investigate fluorescence lifetime imaging ophthalmoscopy (FLIO) in neovascular AMD and pigment epithelial detachments (PEDs). Methods: A total of 46 eyes with PEDs (>350 μm) as well age-matched healthy controls were included this study. We found 28 showed (nvAMD), 17 had nonneovascular (dry) (dAMD). The Heidelberg Engineering FLIO excited at 473 nm. Fluorescence decays detected two spectral channels (498–560 nm; 560–720 nm) to determine lifetimes endogenous fluorophores their...
Abstract Background Hydroxychloroquine has not been associated with improved survival among hospitalized COVID-19 patients in the majority of observational studies and similarly was identified as an effective prophylaxis following exposure a prospective randomized trial. We aimed to explore role hydroxychloroquine therapy mildly symptomatic diagnosed outpatient setting. Methods examined association between subsequent progression disease non-hospitalized documented SARS-CoV-2 infection. The...
Surgical resection remains standard of care for patients with early-stage non-small cell lung cancer (NSCLC), but research shows that adjuvant therapy can reduce the risk disease recurrence. Our objective was to characterize disease-free survival (DFS) using real-world data.This a retrospective study COTA database derived from electronic health records in United States (US). Adults diagnosed stage IB-IIIA NSCLC 2013 2018 who underwent complete surgical (index date) were included. DFS...
Background The COVID-19 pandemic remains a significant global threat. However, despite urgent need, there uncertainty surrounding best practices for pharmaceutical interventions to treat COVID-19. In particular, conflicting evidence has emerged the use of hydroxychloroquine and azithromycin, alone or in combination, Evidence Accelerator convened by Reagan-Udall Foundation FDA, collaboration with Friends Cancer Research, assembled experts from health systems research, regulatory science, data...
BACKGROUND AND OBJECTIVE: To clinically correlate and evaluate the screening treatment patterns of retinopathy prematurity by a single physician at tertiary care center between 2002 2012. PATIENTS METHODS: A group 10,924 newborns screened for ROP 2012 were retrospectively analyzed in consecutive case series. Records neonatal intensive unit (NICU) Jackson Memorial Hospital/Bascom Palmer Eye Institute reviewed to identify patients diagnosed with who underwent treatment. RESULTS: Laser...