A5065097819- Ocular Oncology and Treatments
- Cancer-related Molecular Pathways
- Glioma Diagnosis and Treatment
- Brain Metastases and Treatment
- Global Health and Surgery
- BRCA gene mutations in cancer
- Nonmelanoma Skin Cancer Studies
- Head and Neck Surgical Oncology
- interferon and immune responses
- Epigenetics and DNA Methylation
- Ethics in Clinical Research
- Cancer Genomics and Diagnostics
- Corneal Surgery and Treatments
- Global Maternal and Child Health
- Polyomavirus and related diseases
- Tourism, Volunteerism, and Development
- Biotechnology and Related Fields
- Mental Health and Patient Involvement
- CNS Lymphoma Diagnosis and Treatment
- Retinal Diseases and Treatments
- Ubiquitin and proteasome pathways
- Retinal Development and Disorders
- Glaucoma and retinal disorders
- Ophthalmology and Visual Impairment Studies
- Prenatal Screening and Diagnostics
Institute for Clinical Evaluative Sciences
2016-2025
Hospital for Sick Children
2016-2025
University of Toronto
2016-2025
Public Health Ontario
2016-2025
Centre for Global Health Research
2017-2025
Great Ormond Street Hospital
2018-2024
SickKids Foundation
2015-2024
University College London
2018-2024
Advisory Board Company (United States)
2022
Vancouver General Hospital
2022
Retinoblastoma clinical observations revealed the role of tumor suppressor genes in human cancer, Knudson's 'two-hit' model cancer induction. We now demonstrate that loss both RB1 gene alleles initiates quiescent RB1−/− retinomas with low level genomic instability and high expression senescence-associated proteins p16INK4a p130. Although can remain unchanged throughout life, highly proliferative, clonal aneuploid retinoblastomas commonly emerge, exhibiting altered copy number oncogenes...
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Purpose Initial response of intraocular retinoblastoma to chemotherapy has encouraged primary instead enucleation for eyes with clinical features suggesting high risk extraocular extension or metastasis. Upfront such high-risk allows pathologic evaluation extension, key management appropriate surveillance and adjuvant therapy. Does before mask histologic potentially endangering the child's life by subsequent undertreatment? Methods We performed retrospective analysis 100 advanced enucleated...
<h3>Purpose</h3> Hand-held spectral domain optical coherence tomography (HHSD OCT) has greatly expanded the imaging/diagnostic capacity for clinicians managing children with intraocular retinoblastoma. We present our early experience HHSD OCT and conventional imaging in these patients. <h3>Methods</h3> In this retrospective cross-sectional observational study, infants were imaged during examination under anaesthesia supine position. Older cooperative retinoblastoma patients additionally...
Background. Short-term international volunteer trips traditionally involve volunteers from high-income countries travelling to low- and middle-income assist in service-related development activities. Their duration typically ranges 7 90 days. The city of La Romana, Dominican Republic, receives hundreds short-term annually. They participate activities aimed at improving conditions faced by a marginalized ethnic-Haitian community living bateyes. Methods. This qualitative analysis examined...
Abstract Background Children with retinoblastoma treated carboplatin chemotherapy risk moderate to severe, irreversible hearing loss. Based on published evidence, we hypothesized that ototoxicity is associated clinical parameters and variants in candidate genes drug metabolism pathways (methyltransferases [thiopurine S‐methyltransferase, TPMT ] [catechol‐O‐methyltransferase, COMT ], transporter ABCC3 ). Procedure We retrospectively reviewed records of patients regarding age (at diagnosis...
Strategic, interdisciplinary partnerships are essential to addressing the complex drivers of health inequities that result in survival disparities worldwide. Take for example aggressive early childhood eye cancer retinoblastoma, where reaches 97 % resource-rich countries, but is as low 30 some resource-limited nations, 92 burden lies. This suggests a need multifaceted approach achieve tangible and sustainable increase survival.We assembled history Kenyan National Retinoblastoma Strategy...
ABSTRACT Retinoma, also referred to as retinocytoma, is a benign manifestation of biallelic retinoblastoma gene ( RB1 ) inactivation. Genetic or epigenetic loss protein in maturing cone precursors induces genomic instability which leads upregulation senescence‐associated p16 INK4a and p130, resulting non‐proliferative retinoma. When senescence pathways fail genetic accumulates critical level through altered copies oncogenes tumor suppression genes, transformation into −/‐ occurs. Thus, the...
The body of research and practice regarding student volunteer abroad experiences largely focuses on ensuring the optimal learning experience for from Global North, without equivalent attention to benefits, if any, host institution in South. In this debate article, we examine an often overlooked component global programs: views local partner what makes a mutually beneficial partnership between volunteers North institutions South.To guide our discussion, drew upon Kenyan NGO with Canadian...
Enucleation (eye removal) is often the only curative treatment for childhood eye cancer retinoblastoma, yet parental refusal of enucleation commonly contributes to delay and poor survival globally.Physicians who treat retinoblastoma were surveyed glean underlying reasons refusal.Refusal rates higher when less time was spent with parents explaining retinoblastoma/enucleation, where fewer support services available. Reasons included belief in alternative treatments, culture, social stigma.We...
Objective: Cerebrospinal fluid (CSF) metastasis is the most difficult type of retinoblastoma to cure, even with bone marrow transplant. Most metastatic cells express P-glycoprotein causing multidrug resistance (MDR). P-glycoprotein-rich blood vessels form blood-brain and blood-eye barriers, inhibit drug entry into central nervous system (CNS) eyes. High-dose craniospinal radiation too morbid for treatment young children. To cure CSF without radiation, we designed an intensive multimodality...
<b><i>Background/Aims:</i></b> Clinical cancer genetics is an integral part of control and management, yet its development as essential medical service has been hindered in many low-and-middle-income countries. We report our experiences developing a clinical for retinoblastoma Kenya. <b><i>Methods:</i></b> A task force was created from within the membership existing Kenyan National Retinoblastoma Strategy group. The engaged multiple in-person...