A5090255208- Glioma Diagnosis and Treatment
- Cancer, Hypoxia, and Metabolism
- Cancer Cells and Metastasis
- Cancer, Lipids, and Metabolism
- Caveolin-1 and cellular processes
- 3D Printing in Biomedical Research
- Cancer Mechanisms and Therapy
- Galectins and Cancer Biology
- Microtubule and mitosis dynamics
- Cancer Immunotherapy and Biomarkers
- Immune cells in cancer
- Metabolomics and Mass Spectrometry Studies
- 14-3-3 protein interactions
- Cardiovascular Issues in Pregnancy
- Signaling Pathways in Disease
- Ferroptosis and cancer prognosis
- RNA modifications and cancer
- Cardiac Structural Anomalies and Repair
- Cancer Treatment and Pharmacology
- Takotsubo Cardiomyopathy and Associated Phenomena
- MicroRNA in disease regulation
- ATP Synthase and ATPases Research
- Peripheral Neuropathies and Disorders
- Inflammatory Myopathies and Dermatomyositis
- Lipid metabolism and biosynthesis
Aarhus University Hospital
2024-2025
Odense University Hospital
2018-2024
University of Southern Denmark
2018-2024
F-star (United Kingdom)
2018
The Ark
2017
Abstract Glioblastoma (GBM) displays marked cellular and metabolic heterogeneity that varies among microenvironments within a tumor. Metabolic targeting has long been advocated as therapy against many tumors including GBM, but how lipid metabolism is altered to suit different microenvironmental conditions whether cancer stem cells (CSCs) have are outstanding questions in the field. We interrogated gene expression separate of GBM organoid models mimic transition between nutrient-rich...
Glioblastomas are highly resistant to therapy, and virtually all patients experience tumor recurrence after standard-of-care treatment. Surgical resection is a cornerstone in glioblastoma but its impact on cellular phenotypes the local postsurgical microenvironment has yet be fully elucidated.We developed preclinical orthotopic xenograft model rats with integrated 18F-FET PET/CT imaging. Primary recurrent tumors were subject bulk single-cell RNA sequencing. Differentially expressed genes...
Asymmetric cell division (ACD) enables the maintenance of a stem population while simultaneously generating differentiated progeny. Cancer cells (CSCs) undergo multiple modes during tumor expansion and in response to therapy, yet functional consequences these remain be determined. Using fluorescent reporter for surface receptor distribution mitosis, we found that ACD generated daughter with enhanced therapeutic resistance increased coenrichment EGFR neurotrophin (p75NTR) from glioblastoma...
The infiltrative nature of Glioblastoma (GBM), the most aggressive primary brain tumor, critically prevents complete surgical resection and masks tumor cells behind blood barrier reducing efficacy systemic treatment. Here, we use a genome-wide interference screen to determine invasion-essential genes identify AN1/A20 zinc finger domain containing protein 3 (ZFAND3) as crucial driver GBM invasion. Using patient-derived cellular models, show that loss ZFAND3 hampers invasive capacity GBM,...
ABSTRACT Spontaneous coronary artery dissection (SCAD) is characterized by intramural hematoma in a leading to partial or complete vessel obstruction. A 51‐year‐old female was hospitalized with acute myocardial infarction and cardiogenic shock. She diagnosed severe SCAD, affecting the proximal left artery. complex percutaneous intervention, complicated cardiac arrest need for cardio pulmonary support, succeeded stent insertion revascularization. In following days, patient developed heart...
We have previously identified tissue inhibitor of metalloproteinases-1 (TIMP-1) as a prognostic marker in glioblastomas. TIMP-1 has been associated with chemotherapy resistance, and CD63, known TIMP-1-binding protein, suggested to be responsible for this effect. The aim study was assess CD63 expression astrocytomas focusing on the potential alone combination TIMP-1. investigated immunohistochemically cohort 111 correlated tumor grade overall survival by semi-quantitative scoring....
Abstract Immunotherapeutic targeting of the PD-1/PD-L1 axis has been widely implemented for treatment several cancer types but shown disappointing results in glioblastomas (GBMs), potentially due to compensatory mechanisms other expressed immune checkpoints. Galectin-9 is an immune-checkpoint protein that facilitates T-cell exhaustion and apoptosis could be a potential target inhibition. A total 163 GBMs IDH wildtype were immunostained with anti-Galectin-9 PD-L1 antibodies. Software-based...
Abstract Aims Glioblastoma patients have a dismal prognosis, due to inevitable tumour recurrence and respond poorly immunotherapy. Tumour‐associated microglia/macrophages (TAMs) dominate the glioblastoma microenvironment been implicated in progression immune evasion. Early recurrent glioblastomas contain focal reactive regions with occasional fibrosis, chronic inflammation, TAMs cells. Surgical specimens from these tumours are rare provide crucial insights into biology. This study aimed...
Abstract Most glioblastoma patients have a dismal prognosis, although some survive several years. However, only few biomarkers are available to predict the disease course. EGR1 and EGR3 been linked stemness tumour progression, this study aimed investigate their spatial expression prognostic value in gliomas. Overall 207 gliomas including 190 glioblastomas were EGR1/EGR3 immunostained quantified. A cohort of 21 with high P53 tissue from core periphery was stained double-immunofluorescence...
A 66-year-old man was hospitalised due to worsening of his atrial fibrillation, and successfully underwent an electrocardioversion restore sinus rhythm. He discharged with a prescription 600 mg amiodarone daily retain the rhythm prospectively. 3 weeks after discharge, he noticed that vision became blurry cloudy areas spreading throughout field view on both eyes simultaneously. The visual symptoms gradually worsened following 5 months, patient in department ophthalmology. At this point, had...
Glioblastoma multiforme is the most common primary brain tumor and among lethal types of cancer. Several mono-target small molecule-inhibitors have been investigated as novel therapeutics, thus far with poor success. In this study we anticancer effects SB747651A, a multi-target small-molecule inhibitor, in three well characterized patient-derived glioblastoma spheroid cultures murine orthotopic xenograft model. Concentrations 5-10 µM SB747651A reduced cell proliferation, formation, migration...
Abstract Background Glioblastoma (GBM) is marked by cellular heterogeneity, including metabolic that varies among microenvironments in the same tumor. Altered metabolism cancer well-established, but how lipid altered to suit different microenvironmental conditions and states within a tumor remains unexplored. Methods We assessed GBM organoid models mimic transition zone between nutrient-rich nutrient-poor pseudopalisading/perinecrotic zones performed spatial RNA-sequencing of cells...
Abstract Glioblastoma (GBM) is marked by cellular heterogeneity through microenvironments of a tumor, including metabolic heterogeneity. While altered metabolism in cancer well-known, how lipid different GBM microenvironmental conditions and stem cell (CSC) states within tumor remains an open question. We developed 3-dimensional organoid models that mimic the transition zone between nutrient-rich nutrient-poor psuedopalisading/perinecrotic regions performed spatially defined RNA-sequencing...
Abstract BACKGROUND Glioblastoma is the most frequent and malignant brain tumor. Immune therapies have had limited effect but not much known about frequency type of immune cells in transition zone periphery tumors. In these areas, tumor migrate into parenchyma prevent total resection thereby leading to recurrence. This study aims quantify distribution glioblastomas. MATERIAL AND METHODS A cohort 67 glioblastomas with strong P53 immunoreactivity was established. Slides contained tissue from...
Abstract Introduction Gliomas are the most frequent primary brain tumors. For malignant glioma - glioblastoma median survival is below 15 months. Since only few prognostic biomarkers of benefit in daily practice, new markers urgently needed. EGR1 and EGR3 transcription factors involved regulation cell-cycle cell differentiation, but they have also been associated with migration cancer cells. Studies shown potential breast-, gastric-, colorectal-, prostate cancer. The purpose this study was...
Gliomas are the most frequent primary brain tumors. For malignant glioma - glioblastoma median survival is only 15 months. Few prognostic biomarkers useful in daily practice, and new markers urgently needed. EGR1 EGR3 transcription factors involved regulation of mitogenesis, cell differentiation, has also been suggested to be migration. Both proteins have shown potential other cancers. The aim this study was investigate expression EGR3, their value gliomas. A total 207 gliomas including 190...
Glioblastomas are highly malignant with a median survival time below15 months. Immunotherapy has shown promising results in different types of cancer, and novel therapies targeting PD-1/PD-L1 signalling have been approved for treatment patients melanoma lung cancer. Galectin-9, checkpoint molecule, may be potential therapeutic target. Galectin-9 its receptor, TIM-3, involved cancer cell aggregation, induced T-cell apoptosis, tumor progression. Previous studies indicate that galectin-9...
An asymmetric cell division (ACD) produces a stem and differentiating progeny. Thus ACD ensures the generation of organs with heterogeneous populations without depleting pools cells regenerative capacity. Cancer (CSCs), which are similar to normal cells, can self-renew regenerate tumors cellular heterogeneity. CSCs resistant therapy play critical role in tumor recurrence. has been detected from many types tumors, but its CSC fate decision yet be fully elucidated. A remaining technical...
Background: PD-1/L1 axis blockade shows durable responses and extended overall survival across cancer types in a subset of patients. Tumour Necrosis Factor Receptor (TNFR) superfamily activation is also being tested clinically to improve patient responses. Current interventions using therapeutic CD137 agonists activate T cells are limited by adverse safety effects poor efficacy as monotherapies. The generation bispecific agonist following PD-L1 crosslinking allows greater window with...
Glioblastomas are highly malignant with a median survival time below15 months. Immunotherapy has shown promising results in different types of cancer, and novel therapies targeting PD-1/PD-L1 signalling have been approved for treatment patients melanoma lung cancer. Galectin-9, checkpoint molecule, may be potential therapeutic target. Galectin-9 its receptor, TIM-3, involved cancer cell aggregation, induced T-cell apoptosis, tumor progression. Previous studies indicate that galectin-9...
Gliomas are the most frequent primary brain tumors. For malignant glioma - glioblastoma median survival is only 15 months. Few prognostic biomarkers useful in daily practice, and new markers urgently needed. EGR1 EGR3 transcription factors involved regulation of mitogenesis, cell differentiation, has also been suggested to be migration. Both proteins have shown potential other cancers. The aim this study was investigate expression EGR3, their value gliomas. A total 207 gliomas including 190...