A5002121570- Cardiac electrophysiology and arrhythmias
- Cardiac pacing and defibrillation studies
- Cardiac Arrhythmias and Treatments
- ECG Monitoring and Analysis
- Ion channel regulation and function
- Cardiovascular Function and Risk Factors
- Heart Rate Variability and Autonomic Control
- Atrial Fibrillation Management and Outcomes
- Cardiovascular Effects of Exercise
- Cardiomyopathy and Myosin Studies
- Receptor Mechanisms and Signaling
- Neurological disorders and treatments
- Air Quality and Health Impacts
- Heart Failure Treatment and Management
- Climate Change and Health Impacts
- Cardiac Imaging and Diagnostics
- Cardiac Health and Mental Health
- Cardiac Structural Anomalies and Repair
- Cardiovascular Syncope and Autonomic Disorders
- Lipoproteins and Cardiovascular Health
- Acute Myocardial Infarction Research
- Cardiac Arrest and Resuscitation
- Sports injuries and prevention
- Air Quality Monitoring and Forecasting
- Conducting polymers and applications
University of Rochester Medical Center
2016-2025
University of Rochester
2016-2025
Vanderbilt University Medical Center
2001-2024
Institute for Clinical Evaluative Sciences
2024
University of California, Los Angeles
2024
Cedars-Sinai Smidt Heart Institute
2024
Cedars-Sinai Medical Center
2024
Children's Hospital of Pittsburgh
2023-2024
University of Pittsburgh
2001-2024
XinHua Hospital
2023-2024
Patients with reduced left ventricular function after myocardial infarction are at risk for life-threatening arrhythmias. This randomized trial was designed to evaluate the effect of an implantable defibrillator on survival in such patients.
This trial was designed to determine whether cardiac-resynchronization therapy (CRT) with biventricular pacing would reduce the risk of death or heart-failure events in patients mild cardiac symptoms, a reduced ejection fraction, and wide QRS complex.During 4.5-year period, we enrolled followed 1820 ischemic nonischemic cardiomyopathy, an fraction 30% less, duration 130 msec more, New York Heart Association class I II symptoms. Patients were randomly assigned 3:2 ratio receive CRT plus...
Background— In 1994, an International Task Force proposed criteria for the clinical diagnosis of arrhythmogenic right ventricular cardiomyopathy/dysplasia (ARVC/D) that facilitated recognition and interpretation frequently nonspecific features ARVC/D. This enabled confirmatory in index cases through exclusion phenocopies provided a standard on which research genetic studies could be based. Structural, histological, electrocardiographic, arrhythmic, familial disease were incorporated into...
Background —The congenital long-QT syndrome (LQTS) is caused by mutations on several genes, all of which encode cardiac ion channels. The progressive understanding the electrophysiological consequences these opens unforeseen possibilities for genotype-phenotype correlation studies. Preliminary observations suggested that conditions (“triggers”) associated with events may in large part be gene specific. Methods and Results —We identified 670 LQTS patients known genotype (LQT1, n=371; LQT2,...
In 1994, an International Task Force proposed criteria for the clinical diagnosis of arrhythmogenic right ventricular cardiomyopathy/dysplasia (ARVC/D) that facilitated recognition and interpretation frequently nonspecific features ARVC/D. This enabled confirmatory in index cases through exclusion phenocopies provided a standard on which research genetic studies could be based. Structural, histological, electrocardiographic, arrhythmic, familial disease were incorporated into criteria,...
The implantable cardioverter–defibrillator (ICD) is highly effective in reducing mortality among patients at risk for fatal arrhythmias, but inappropriate ICD activations are frequent, with potential adverse effects.
Background —β-blockers are routinely prescribed in congenital long-QT syndrome (LQTS), but the effectiveness and limitations of β-blockers this disorder have not been evaluated. Methods Results —The study population comprised 869 LQTS patients treated with β-blockers. Effectiveness was analyzed during matched periods before after starting β-blocker therapy, by survivorship methods to determine factors associated cardiac events while on After initiation β-blockers, there a significant ( P...
This study aimed to determine whether QRS morphology identifies patients who benefit from cardiac resynchronization therapy with a defibrillator (CRT-D) and it influences the risk of primary secondary end points in enrolled Multicenter Automatic Defibrillator Implantation Trial-Cardiac Resynchronization Therapy (MADIT-CRT) trial.Baseline 12-lead ECGs were evaluated regard morphology. Heart failure event or death was point trial. Death, heart event, ventricular tachycardia, fibrillation...
The congenital long-QT syndrome, caused by mutations in cardiac potassium-channel genes (KVLQT1 at the LQT1 locus and HERG LQT2 locus) sodium-channel gene (SCN5A LQT3 locus), has distinct repolarization patterns on electrocardiography, but it is not known whether genotype influences clinical course of disease.
The management of long-QT syndrome (LQTS) patients who continue to have cardiac events (CEs) despite beta-blockers is complex. We assessed the long-term efficacy left sympathetic denervation (LCSD) in a group high-risk patients.We identified 147 LQTS underwent LCSD. Their QT interval was very prolonged (QTc, 543+/-65 ms); 99% were symptomatic; 48% had arrest; and 75% those treated with remained symptomatic. average follow-up periods between first CE LCSD post-LCSD 4.6 7.8 years,...
The long QT syndrome is an inherited disorder with prolonged ventricular repolarization and a propensity to tachyarrhythmias sudden arrhythmic death. Recent linkage studies have demonstrated three separate loci for this on chromosomes 3, 7, 11, specific mutated genes been identified two of these chromosomes. We investigated ECG T-wave patterns (phenotypes) in members families linked genetically distinct forms the syndrome.Five quantitative parameters, ie, four Bazett-corrected time intervals...
The implanted cardioverter defibrillator (ICD) improves survival in high-risk cardiac patients. This analysis from the MADIT-II trial database examines long-term clinical course and subsequent mortality risk of patients after termination life-threatening ventricular tachyarrhythmias by an ICD.Life-table was performed, proportional hazards regression used to evaluate contribution baseline factors time-dependent therapy during follow-up. Of 720 with ICD (average follow-up 21 months), 169...
Background— An important determinant of successful cardiac resynchronization therapy for heart failure is the position left ventricular (LV) pacing lead. The aim this study was to analyze impact LV lead on outcome in patients randomized resynchronization-defibrillation Multicenter Automatic Defibrillator Implantation Trial–Cardiac Resynchronization Therapy (MADIT-CRT) study. Methods and Results— location assessed by means coronary venograms chest x-rays recorded at time device implantation....
Background —Unexplained female predominance is observed in long-QT syndrome (LQTS), a congenital autosomal disorder with prolonged repolarization and syncope or sudden death due to ventricular tachyarrhythmias. Our objectives were evaluate age- sex-related differences events among LQTS patients referred the International Registry. Methods Results —Age- occurrence of was analyzed 479 probands (70% females) 1041 affected family members (QT c >440 ms, 58% females). LQTS-gene mutations...
Congenital long-QT syndrome (LQTS) is caused by mutations of genes encoding the slow component delayed rectifier current (LQT1, LQT5), rapid (LQT2, LQT6), or Na(+) (LQT3), resulting in ST-T-wave abnormalities on ECG. This study evaluated spectrum patterns and repolarization parameters genotype determined whether could be identified ECG.ECGs 284 gene carriers were studied to determine patterns, quantified. Genotypes individual ECG versus family-grouped analysis separate studies using ECGs 146...
Background— Type-1 long-QT syndrome (LQTS) is caused by loss-of-function mutations in the KCNQ1-encoded I Ks cardiac potassium channel. We evaluated effect of location, coding type, and biophysical function KCNQ1 on clinical phenotype this disorder. Methods Results— investigated course 600 patients with 77 different 101 proband-identified families derived from US portion International LQTS Registry (n=425), Netherlands’ (n=93), Japanese (n=82). The Cox proportional hazards survivorship model...
The hereditary long-QT syndrome is characterized by prolonged ventricular repolarization and a variable clinical course with arrhythmia-related syncope sudden death. Mutations involving the human ether-a-go-go-related gene (HERG) channel are responsible for LQT2 form of syndrome, in cellular expression studies these mutations associated reduction rapid component delayed rectifier repolarizing current (I(Kr)). We investigated features prognostic implications pore nonpore regions HERG this...