A5004214366- Cardiovascular and exercise physiology
- Cardiac Arrhythmias and Treatments
- Cardiovascular Effects of Exercise
- Cardiac electrophysiology and arrhythmias
- ECG Monitoring and Analysis
- Cardiac pacing and defibrillation studies
- Physical Activity and Health
- Cardiovascular Disease and Adiposity
- Cardiac Imaging and Diagnostics
- Ion channel regulation and function
- Cardiovascular Function and Risk Factors
- Sports Performance and Training
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Bariatric Surgery and Outcomes
- Cardiomyopathy and Myosin Studies
- Acute Myocardial Infarction Research
- Health and Lifestyle Studies
- Genetics and Physical Performance
- Hemodynamic Monitoring and Therapy
- Adipokines, Inflammation, and Metabolic Diseases
- Occupational Health and Performance
- Transplantation: Methods and Outcomes
- Exercise and Physiological Responses
- Heart Rate Variability and Autonomic Control
- Nutrition and Health in Aging
University of Utah
2009-2024
Intermountain Medical Center
2019-2024
Intermountain Healthcare
2005-2013
LDS Hospital
1990-2010
Brigham Young University
1980-2005
University of Utah Hospital
1977-2004
University of South Carolina
2000-2002
University of North Carolina at Greensboro
2002
Bikur Cholim Hospital
2000
University of Michigan
1987-2000
Fifty patients with acute myocardial infarction were randomly assigned to receive either intracoronary streptokinase or standard (control) therapy within about three hours after the onset of pain. Coronary perfusion was reestablished in 19 24 receiving streptokinase. Streptokinase alleviated pain (as indicated by differences subsequent morphine use). The Killip class significantly improved streptokinase, as changes radionuclide ejection fraction between Days 1 and 10 surviving (+3.9 vs. -3.0...
Congenital long-QT syndrome (LQTS) is caused by mutations of genes encoding the slow component delayed rectifier current (LQT1, LQT5), rapid (LQT2, LQT6), or Na(+) (LQT3), resulting in ST-T-wave abnormalities on ECG. This study evaluated spectrum patterns and repolarization parameters genotype determined whether could be identified ECG.ECGs 284 gene carriers were studied to determine patterns, quantified. Genotypes individual ECG versus family-grouped analysis separate studies using ECGs 146...
Despite the popularity of concept “anaerobic threshold” (AT), noninvasive detection criteria remain subjective, and invasive validations AT have been based on lactate data arterial, mixed venous, capillary blood samples without any concern for possible differences from these sources. Eight normal subjects underwent two exercise tests a bicycle ergometer. The protocol consisted 3 min rest, 0 work load, 20 W/min ramp (1 W/3 s) until exhaustion. Simultaneous arterial venous were drawn during...
BACKGROUND We investigated the effects of bucindolol, a nonselective, non-ISA beta-blocker with mild-vasodilatory properties, in patients congestive heart failure from ischemic dilated cardiomyopathy (ISCDC, n = 27) and compared results those subjects idiopathic (IDC, 22). METHODS AND RESULTS Patients were randomized double-blind fashion to receive 12 weeks' treatment either bucindolol or placebo, randomization stratified for IDC ISCDC: Invasive (right catheterization) noninvasive (echo,...
Background — Elevated C-reactive protein (CRP) is associated with increased coronary heart disease (CHD) risk. Cardiorespiratory fitness (“fitness”) related lower CHD risk; however, its relationship CRP relatively unknown. Methods and Results Cross-sectional associations between plasma were examined among 135 African American (AA), Native (NA), Caucasian (CA) women (55±11 year; 28±6 kg/m 2 ). Fitness was assessed a maximal treadmill exercise test. Plasma concentrations determined the Dade...
This report presents the results of coronary angiography in 76 asymptomatic aircrewmen with exercise testing responses suggestive artery disease. There were two subgroups: 18 men normal resting electrocardiograms; and 58 a history repolarization changes on their electrocardiogram after at least one ECG. Of men, 53% had angiographically demonstrated disease, many them high risk lesions. Forty-seven percent no angiographic evidence lesions recommended for return to flying status. Those...
Favorable health outcomes at 2 years postbariatric surgery have been reported. With exception of the Swedish Obesity Subjects (SOS) study, these studies surgical case series, comparison types, or patients compared to subjects enrolled in planned nonsurgical intervention. This study measured gastric bypass effectiveness when two separate severely obese groups not participating designed weight-loss Three (N = 1,156, BMI >or= 35 kg/m(2)) were studied: (n 420), seeking but did 415), and...
The clinical effects of intravenous streptokinase in patients with acute myocardial infarction were compared those intracoronary a randomized, prospective study. Comparisons also made historical control group. Fifty entered into the study at 2.4 +/- 1.2 hr after onset pain, and 27 assigned to 23 therapy. doses averaged 212,000 U ic 845,000 iv (0.75 X 10(6) U/5 hr, n = 14 or U/1 13). Results studies two dosage schedules similar so combined. Streptokinase was administered 2.8 1.0 pain 4.3 1.4...
A computerized method has been developed to determine the conductance characteristics of pneumotachometers. Conductance values flowmeter, which correspond all pressure values, can be determined by a weighted averaging technique, when multiple strokes precision 3-liter calibrated syringe are used. The then allow measured differential pressures converted, point point, into flows. accuracy volumes is within +/- 0.5% for 100-stroke calibration process, and with 50 provides 1% accuracy. improves...
Because of the uncertainty as to extent which cardiac size is determined by exercise training vs genetic endowment, this study investigated familial (genetic plus common family environment) nonfamilial influences on size. College-age monozygotic twins (group 1, 31 sets), dizygotic 2, 10 siblings like sex 3, six and nonrelated subjects 4, 15 sets) underwent echocardiographic electrocardiographic tests, measurement maximum oxygen uptake (VO2max), evaluation pulmonary body composition; mean...
The purpose of this study was to assess noninvasively the effects intense aerobic training on cardiac structure and function in a group healthy, college-age men (25 experimental 11 control, mean age 22 years). Echocardiographic, electrocardiographic (ECG), fitness measurements were obtained before after 3-month endurance program compared with similar nonexercising subjects. supervised consisted 50-minute jogging sessions 5 days week at 85% maximal heart rate. Compared control group,...
Abstract The purpose of this study was to develop a regression equation predict maximal oxygen uptake (VO2max) based on nonexercise (N-EX) data. All participants (N= 100), ages 18–65 years, successfully completed graded exercise test (GXT) assess VO2max (M= 39.96 mL·kg -1· min -1 , SD = 9.54). N-EX data collected just before the GXT included participant's age; gender; body mass index (BMI); perceived functional ability (PFA) walk, jog, or run given distances; and current physical activity...
Background —Cardiorespiratory fitness is favorably associated with most modifiable coronary heart disease (CHD) risk factors. Findings are limited, however, by few data for women, persons existing CHD, and low-risk populations. In the present study, we described cross-sectional associations between cardiorespiratory CHD factors in a large cohort of middle-aged men whom majority were LDS Church members (Mormons), without CHD. Methods Results —Comprehensive health examinations performed on...
The purpose of this study was to determine the 2-year impact a worksite-based diabetes prevention program. Thirty-seven pre-diabetic and previously undiagnosed diabetic employees participating in 12-month worksite program were included. Weight, body mass index, waist circumference, oral glucose tolerance testing, fasting insulin, blood lipids, aerobic fitness had improved significantly after 6 months. Much improvement continued through 12 One year following intervention, significantly. Of 22...
This study sought to develop a regression model predict maximal oxygen uptake (VO2max) based on submaximal treadmill exercise (EX) and non-exercise (N-EX) data involving 116 participants, ages 18–65 years. The EX included the participants' self-selected speed (at level grade) when heart rate first reached at least 70% of predicted maximum (HRmax; 220 – age) by end any one three 4-min consecutive stages walking (3.0–4.0 mph; Stage 1), jogging (4.1–6.0 2), running (> 6.0 3). N-EX various...
The purpose of this study was to investigate the characteristics a newly developed turbine flowmeter (Alpha Technologies, model VMM-2) for use in an exercise testing system by comparing its measurement expiratory flow (VE), O2 uptake (VO2), and CO2 output (VCO2) with Fleisch pneumotachometer. An IBM PC/AT-based breath-by-breath developed, dual-Fleisch pneumotachometers connected series. A normal subject tested twice at rest, 100-W, 175-W exercise. Expired gas 24–32 breaths collected Douglas...