A5089845667- Prostate Cancer Diagnosis and Treatment
- Statistical Methods and Bayesian Inference
- Dental Implant Techniques and Outcomes
- Statistical Methods and Inference
- Dental materials and restorations
- Dental Health and Care Utilization
- Orthodontics and Dentofacial Orthopedics
- Prostate Cancer Treatment and Research
- Statistical Methods in Clinical Trials
- Oral microbiology and periodontitis research
- Bladder and Urothelial Cancer Treatments
- Dental Research and COVID-19
- Dental Radiography and Imaging
- Periodontal Regeneration and Treatments
- Health Systems, Economic Evaluations, Quality of Life
- Temporomandibular Joint Disorders
- Advanced Statistical Methods and Models
- Anesthesia and Pain Management
- Urinary and Genital Oncology Studies
- Urological Disorders and Treatments
- Cancer survivorship and care
- Advanced Causal Inference Techniques
- HIV Research and Treatment
- Influenza Virus Research Studies
- Urologic and reproductive health conditions
Simon Fraser University
2025
University of Rochester Medical Center
2015-2024
University of Rochester
2015-2024
Jiaxing Hengchuang Electric Design and Research Institute
2024
Hangzhou Dianzi University
2023
Creative Commons
2018
Eastman Chemical Company (United States)
2018
Université de Lille
2018
University of California, San Diego
2017
American College of Surgeons
2013
The log-transformation is widely used in biomedical and psychosocial research to deal with skewed data. This paper highlights serious problems this classic approach for dealing Despite the common belief that log transformation can decrease variability of data make conform more closely normal distribution, usually not case. Moreover, results standard statistical tests performed on log-transformed are often relevant original, non-transformed data.We demonstrate these by presenting examples use...
The hereditary long-QT syndrome is characterized by prolonged ventricular repolarization and a variable clinical course with arrhythmia-related syncope sudden death. Mutations involving the human ether-a-go-go-related gene (HERG) channel are responsible for LQT2 form of syndrome, in cellular expression studies these mutations associated reduction rapid component delayed rectifier repolarizing current (I(Kr)). We investigated features prognostic implications pore nonpore regions HERG this...
Sex, race, and age at diagnosis have a significant impact on mortality from bladder cancer (BC). Women, African Americans of both sexes, the elderly, all experience higher rates. Tumor grade, stage, histologic type presentation also affect outcome. To determine whether tumor characteristics alone explain excess hazard death BC observed in some demographic groups, authors queried Surveillance, Epidemiology, End Results (SEER) limited-use database for presentations outcomes between 1990...
Agreement and correlation are widely-used concepts that assess the association between variables. Although similar related, they represent completely different notions of association. Assessing agreement variables assumes measure same construct, while can be assessed for constructs. This conceptual difference requires use statistical methods, when assessing or correlation, method may vary depending on distribution data interest investigator. For example, Pearson a popular continuous...
In clinical research, comparisons of the results from experimental and control groups are often encountered. The two-sample t-test (also called independent samples t-test) paired probably most widely used tests in statistics for comparison mean values between two samples. However, confusion exists with regard to use test methods, resulting their inappropriate use. this paper, we discuss differences similarities these t-tests. Three examples illustrate calculation procedures...
The log transformation has been widely used in biomedical research to deal with the skewed data. However, medical publications, we have found many misuses and misinterpretations of analysis based on log‐transformed In this paper, list some common scenarios misuse misinterpretation applications. We also provide both theoretical practical justifications support our viewpoints. Copyright © 2012 John Wiley & Sons, Ltd.
In Brief OBJECTIVE: To assess the effect of low-dose mifepristone on quality life, pain, bleeding, and uterine size among women with symptomatic leiomyomata. METHODS: Forty-two leiomyomata volume 160 mL or more were randomized to mifepristone, 5 mg daily, placebo for 26 weeks. Quality life (Uterine Fibroid Symptoms Life Questionnaire Medical Outcomes Study 36-Item Short Form survey) leiomyoma (ultrasonography) assessed at baseline, 1 month, 3 months, 6 months treatment. Bleeding (daily logs...
Abstract BACKGROUND. The objectives of this study were to determine whether bladder cancer (BC) screening in healthy men could lead earlier detection and reduced BC mortality compared with unscreened long‐term outcomes a geographically defined, population newly diagnosed BC. METHODS. In 1987 from 1998 1992, 1575 ages 50 years older who solicited well patient rosters clinics around Madison, Wisconsin, tested their urine repetitively chemical reagent strip for hemoglobin. Participants had...
Abstract Purpose: The objective of this study was to compare the effect veneering porcelain (monolithic or bilayer specimens) and core fabrication technique (heat‐pressed CAD/CAM) on biaxial flexural strength Weibull modulus leucite‐reinforced lithium‐disilicate glass ceramics. In addition, powder/liquid layering) for zirconia ceramics studied. Materials Methods: Five ceramic materials (IPS Empress Esthetic, IPS CAD, e.max Press, ZirCAD) three corresponding porcelains Esthetic Veneer, Ceram,...
Candida albicans is an opportunistic fungal organism frequently detected in the oral cavity of children with severe early childhood caries (S-ECC). Previous studies suggested cariogenic potential C. albicans, vitro and vivo, further demonstrated its synergistic interactions Streptococcus mutans. In combination, 2 organisms are associated higher severity a rodent model. However, it remains unknown whether influences composition diversity entire bacterial community to promote S-ECC onset. With...
Introduction Candida albicans has been detected together with Streptococcus mutans in high numbers plaque-biofilm from children early childhood caries (ECC). The goal of this study was to examine the C. carriage severe (S-ECC) and maternal relatedness. Methods Subjects pilot cross-sectional were recruited based on a convenient sample. DMFT(S)/dmft(s) plaque scores assessed during comprehensive oral exam. Social-demographic related background information collected through questionnaire....
Abstract Introduction Psoriatic arthritis (PsA) is a chronic inflammatory characterized by bone erosion mediated osteoclasts (OC). Our previous studies showed an elevated frequency of OC precursors (OCP) in PsA patients. Here, we examined if arise from CD16-positive monocytes PsA. Methods Peripheral blood mononuclear cells (PBMC) or were isolated human peripheral and sorted based on CD16 expression. Sorted cultured alone with wafers the presence receptor activator nuclear factor kappa-B...
Abstract Osteoclasts (OC) are bone-resorbing, multinucleated cells that generated via fusion of OC precursors (OCP). The frequency OCP is elevated in patients with erosive inflammatory arthritis and metabolic bone diseases. Although many cytokines cell surface receptors known to participate osteoclastogenesis, the molecular mechanisms underlying regulation this cellular transformation poorly understood. Herein, we focused our studies on text-decoration:underlineendritic...
Abstract The generalized linear mixed‐effects model (GLMM) is a popular paradigm to extend models for cross‐sectional data longitudinal setting. When applied modeling binary responses, different software packages and even procedures within package may give quite results. In this report, we describe the statistical approaches that underlie these discuss their strengths weaknesses when fit correlated responses. We then illustrate considerations by applying implemented in some simulated real...
Abstract Introduction As a group, rheumatoid arthritis (RA) patients exhibit increased risk of infection, and those treated with anti-tumor necrosis factor (TNF) therapy are at further risk. This susceptibility may result from compromised humoral immune response. Therefore, we asked if short-term effector (d5-d10) memory (1 month or later) B cell responses to antigen were in RA anti-TNF therapy. Methods Peripheral blood samples obtained patients, including subset anti-TNF, healthy controls...
No AccessJournal of UrologyAdult Urology1 Jan 2018A Comprehensive Analysis Cribriform Morphology on Magnetic Resonance Imaging/Ultrasound Fusion Biopsy Correlated with Radical Prostatectomy Specimensis corrected byErratum Matthew Truong, Changyong Feng, Gary Hollenberg, Eric Weinberg, Edward M. Messing, Hiroshi Miyamoto, and Thomas P. Frye TruongMatthew Truong Department Urology, University Rochester Medical Center, Rochester, New York More articles by this author , FengChangyong Feng...
Abstract Background: Most studies examining the prognostic value of preoperative coagulation testing are too small to examine predictive routine in patients having noncardiac surgery. Methods: Using data from American College Surgeons National Surgical Quality Improvement database, authors performed a retrospective observational study on 316,644 surgery who did not have clinical indications for testing. The used multivariable logistic regression analysis explore association between platelet...
Ventricular tachycardia (VT) and ventricular fibrillation (VF) remain a challenging problem in patients with implantable cardioverter-defibrillators (ICDs).This study aimed to determine whether ranolazine administration decreases the likelihood of VT, VF, or death an ICD.This was double-blind, placebo-controlled clinical trial which high-risk ICD ischemic nonischemic cardiomyopathy were randomized 1,000 mg twice day placebo. The primary endpoint VT VF requiring appropriate therapy death,...
There is a dearth of studies that have compared clinical and radiologic markers periodontal inflammation between water-pipe smokers (WPs) cigarette (CSs). The aim the present study to compare radiographic status habitual WPs CSs.In total, 200 males (50 WPs, 50 CSs, 100 controls) with comparable mean age education were included. Demographic information was recorded using questionnaire. Periodontal parameters (plaque index [PI], bleeding on probing [BOP], depth [PD], attachment loss [AL],...
The restriction of resident hours with an increasing focus on patient safety and a reduced caseload has impacted surgical training. A complex complication prone procedure such as percutaneous nephrolithotomy (PCNL) steep learning curve may create unsafe environment for hands-on In this study, we validate high fidelity, inanimate PCNL model within full-immersion simulation environment.Anatomically correct models the human pelvicaliceal system, kidney, relevant adjacent structures were created...
Logistic regression is a popular statistical method in studying the effects of covariates on binary outcomes. It has been widely used both clinical trials and observational studies. However, results from univariate multiple logistic tend to be conflicting. A covariate may show very strong effect outcome but not regression, vice versa. These facts have well appreciated biomedical research. Misuse prevalent medical publications. In this paper, we study inconsistency between regressions give...