A5080152292- Rheumatoid Arthritis Research and Therapies
- Spondyloarthritis Studies and Treatments
- Systemic Lupus Erythematosus Research
- Autoimmune and Inflammatory Disorders Research
- Bone and Joint Diseases
- Bone Metabolism and Diseases
- Psoriasis: Treatment and Pathogenesis
- Systemic Sclerosis and Related Diseases
- Musculoskeletal synovial abnormalities and treatments
- Osteoarthritis Treatment and Mechanisms
- Primary Care and Health Outcomes
- Bone health and treatments
- Inflammatory Bowel Disease
- Innovations in Medical Education
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Global Health Workforce Issues
- COVID-19 and Mental Health
- Lymphoma Diagnosis and Treatment
- Healthcare professionals’ stress and burnout
- Gout, Hyperuricemia, Uric Acid
- Phagocytosis and Immune Regulation
- NF-κB Signaling Pathways
- Ethics in Clinical Research
- Diversity and Career in Medicine
- Bone health and osteoporosis research
University of Rochester Medical Center
2009-2024
University of Rochester
2004-2022
In-Q-Tel
2004
Abstract Introduction As a group, rheumatoid arthritis (RA) patients exhibit increased risk of infection, and those treated with anti-tumor necrosis factor (TNF) therapy are at further risk. This susceptibility may result from compromised humoral immune response. Therefore, we asked if short-term effector (d5-d10) memory (1 month or later) B cell responses to antigen were in RA anti-TNF therapy. Methods Peripheral blood samples obtained patients, including subset anti-TNF, healthy controls...
<h3>Objective:</h3> The frequency of osteoclast precursors (OCPF) and the presence bone marrow oedema (BMO) are potential response biomarkers in psoriatic arthritis (PsA). Previous studies suggest a central role for tumour necrosis factor (TNF) formation precursors. To better understand this association, effect etanercept on OCPF BMO was analysed PsA patients with erosive arthritis. <h3>Methods:</h3> A total 20 active were enrolled. Etanercept administered twice weekly 24 weeks. measured...
Objective. To develop and validate a magnetic resonance imaging (MRI) method of assessment joint space narrowing (JSN) in rheumatoid arthritis (RA). Methods. Phase A: JSN was scored 0–4 on MR images 5 RA patients 3 controls at 15 wrist sites 2nd–5th metacarpophalangeal (MCP) joints by 8 readers (7 once, one twice), using preliminary scoring system. B: Image review, discussion, consensus definition, revised C: 4 were system (4 results compared with radiographs [Sharp-van der Heijde (SvdH)...
Background: Bone marrow oedema (BMO), synovitis, effusion and joint erosion on magnetic resonance imaging (MRI) may be used as outcome measures in psoriatic arthritis (PsA). Objective: To assess the impact of adalimumab BMO, erosions PsA, measured by MRI. Methods: Fifteen patients with active PsA (⩾3 tender ⩾3 swollen joints) were enrolled an open-label pilot study. Each received subcutaneously every other week for 24 weeks. MRI was obtained at baseline Results: available 11 patients, pre...
Objective. The purpose of our study was to test the hypothesis that synovitis on magnetic resonance imaging (MRI) and ultrasound (US) observed in patients with rheumatoid arthritis (RA) who meet remission criteria reflects active inflammation histopathology. Methods. We analyzed 15 synovial specimens obtained during surgical procedures from 14 RA clinical as defined by American College Rheumatology criteria. Histological were scored for hyperplasia lining stroma, inflammation, lymphoid...
Objectives The objective of this study was to calculate the direct and indirect costs admission for systemic lupus erythematosus (SLE) patients, identify population at risk investigate potential reasons admission. Methods We conducted a financial analysis all admissions SLE Strong Memorial Hospital between 1 July 2013 30 June 2015. Patient records with diagnosis above period were retrieved. total cost used as measure length stay assess costs. Additionally, we analyzed demographics...
Objective. To compare disease activity, radiographic features, and bone density in psoriatic arthritis (PsA) rheumatoid (RA) matched cohorts. Methods. Disease activity data the Consortium of Rheumatology Researchers North America database from 2001 to 2008 were compared for 2481 patients with PsA 17,107 RA subsequently age, gender, duration. Radiographic outcomes included presence erosions, joint deformity. In addition, mineral (BMD) scores lumbar spine (L-spine) femoral neck using same...
Substantial disparities exist in clinical trial participation, which is problematic diseases such as lupus that disproportionately affect racial/ethnic minority populations. Our objective was to examine the effectiveness of an online educational course aiming train medical providers refer Black and Latino patients trials (LCTs).The American College Rheumatology's Materials Increase Minority Involvement Clinical Trials (MIMICT) study used online, randomized, 2-group, pretest/posttest design...
The OMERACT magnetic resonance imaging (MRI) in inflammatory arthritis group previously developed the rheumatoid MRI score (RAMRIS) for use clinical studies, evaluated of extremity MRI, and initiated development a psoriatic (PsAMRIS). At 9 looked at clarifications applying RAMRIS, presented data from study examining how contrast agent gadolinium affects RAMRIS outcomes. Much group’s effort has been aimed iterative its PsA score, reported exercises this demonstrated encouraging results,...
Erosive osteoarthritis (EOA) represents a subset of symptomatic hand, characterized by intermittent and often frequent inflammatory episodes progressive joint damage. A greater degree inflammation the presence subchondral bone erosions on plain radiographs help distinguish EOA from generalized hand. High resolution ultrasound magnetic resonance imaging (MRI) have demonstrated synovitis MRI has additionally highlighted role in bone, tendons, ligaments EOA. Further evidence for crucial comes...