A5091871404- Psoriasis: Treatment and Pathogenesis
- Spondyloarthritis Studies and Treatments
- Rheumatoid Arthritis Research and Therapies
- Autoimmune and Inflammatory Disorders Research
- Health Systems, Economic Evaluations, Quality of Life
- Dermatology and Skin Diseases
- Fibromyalgia and Chronic Fatigue Syndrome Research
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Infectious Diseases and Tuberculosis
- Streptococcal Infections and Treatments
- Hidradenitis Suppurativa and Treatments
- Tuberculosis Research and Epidemiology
- Immunotherapy and Immune Responses
- Systemic Lupus Erythematosus Research
- Mycobacterium research and diagnosis
- Chemotherapy-related skin toxicity
- Drug-Induced Adverse Reactions
- Pharmaceutical studies and practices
- Blood transfusion and management
- Genital Health and Disease
- Biosimilars and Bioanalytical Methods
- Food Allergy and Anaphylaxis Research
- Syphilis Diagnosis and Treatment
- Cardiac Arrest and Resuscitation
New York University
2016-2025
University of Virginia
2023-2024
NYU Langone Health
2018-2023
Center for Rheumatology
2021-2022
Albert Einstein College of Medicine
2021
The Bronx Defenders
2021
GlaxoSmithKline (India)
2021
AstraZeneca (Brazil)
2021
Pfizer (United Kingdom)
2021
Sanofi (Mexico)
2021
Objective To characterize the diversity and taxonomic relative abundance of gut microbiota in patients with never‐treated, recent‐onset psoriatic arthritis (PsA). Methods High‐throughput 16S ribosomal RNA pyrosequencing was utilized to compare community composition PsA (n = 16), psoriasis skin 15), healthy, matched control subjects 17). Samples were further assessed for presence levels fecal serum secretory IgA (sIgA), proinflammatory proteins, fatty acids. Results The observed less diverse...
Objective To develop an evidence‐based guideline for the pharmacologic and nonpharmacologic treatment of psoriatic arthritis (PsA), as a collaboration between American College Rheumatology ( ACR ) National Psoriasis Foundation NPF ). Methods We identified critical outcomes in PsA clinically relevant PICO (population/intervention/comparator/outcomes) questions. A Literature Review Team performed systematic literature review to summarize evidence supporting benefits harms available therapies...
To investigate the humoral and cellular immune response to messenger RNA (mRNA) COVID-19 vaccines in patients with immune-mediated inflammatory diseases (IMIDs) on immunomodulatory treatment.
To characterize the ecological effects of biologic therapies on gut bacterial and fungal microbiome in psoriatic arthritis (PsA)/spondyloarthritis (SpA) patients.Fecal samples from PsA/SpA patients pre- posttreatment with tumor necrosis factor inhibitors (TNFi; n = 15) or an anti-interleukin-17A monoclonal antibody inhibitor (IL-17i; 14) underwent sequencing (16S ribosomal RNA, internal transcribed spacer shotgun metagenomics) computational analysis. Fecal levels fatty acid metabolites...
Optimal management of patients with both psoriasis and psoriatic arthritis (PsA) necessitates collaboration among dermatologists rheumatologists. In this manuscript, we discuss challenges opportunities for dual care models PsA the results a survey combined clinics based in North America.
To investigate the humoral and cellular immune response to mRNA COVID-19 vaccines in patients with immune-mediated inflammatory diseases (IMIDs) on immunomodulatory treatment.Established at NYU Langone Health IMID (n=51) receiving BNT162b2 vaccination were assessed baseline after second immunization. Healthy subjects served as controls (n=26). IgG antibody responses spike protein analyzed for response. Cellular SARS-CoV-2 was further using high-parameter spectral flow cytometry. A...
Despite significant therapeutic advances in psoriatic arthritis (PsA), many patients do not achieve remission and cycle through multiple biologic (b)- or targeted synthetic (ts)- DMARDs. Identifying the underlying reasons for repetitive failure remains a knowledge gap. Here we describe prescribing patterns characteristics of PsA with multi-b/tsDMARD at NYU Psoriatic Arthritis Center. Nine hundred sixty were enrolled an observational, longitudinal registry. Demographics, medical history,...
Psoriatic arthritis (PsA) is a multi-domain, inflammatory disease impacting joints, soft tissues, and skin; tumor necrosis factor inhibitors (TNFi) are typically the first biologic following inadequate response (IR) to conventional therapies. Although guidance lacking on therapy selection after initial TNFi failure, data suggest TNFi-IR PsA patients may benefit from switching different mechanism of action (MOA) vs. cycling another TNFi. Guselkumab fully human monoclonal antibody targeting...
Objective The aim was to examine patient‐reported treatment goals among individuals with psoriatic arthritis (PsA). Methods Participants in the Psoriatic Arthritis Research Consortium (PARC) completed standardized assessments including outcome (PROs) instruments between 2017‐2020. Additionally, participants were asked two open‐ended questions at enrollment or therapy initiation “If you could improve one thing about your disease, what would it be?” and “What an effective change for you?”...
Rheumatoid arthritis (RA) is a chronic inflammatory disease that can be managed with range of therapeutic treatments. Methotrexate (MTX) first-line treatment for RA; however, its metabolism in RA patients complicated by multiple factors. Therefore, understanding these specific factors crucial optimizing the efficacy MTX to provide improved outcomes patients. This article explores existing literature examine how impacted other commonly used medications RA. Additionally, review role genetics...
Psoriatic disease remains underdiagnosed and undertreated. We developed validated a suite of novel, sensor-based smartphone assessments (Psorcast app) that can be self-administered to measure cutaneous musculoskeletal signs symptoms psoriatic disease. Participants with psoriasis (PsO) or arthritis (PsA) healthy controls were recruited between June 5, 2019, November 10, 2021, at 2 academic medical centers. Concordance accuracy digital measures image-based machine learning models compared...
Objective. To compare disease activity, radiographic features, and bone density in psoriatic arthritis (PsA) rheumatoid (RA) matched cohorts. Methods. Disease activity data the Consortium of Rheumatology Researchers North America database from 2001 to 2008 were compared for 2481 patients with PsA 17,107 RA subsequently age, gender, duration. Radiographic outcomes included presence erosions, joint deformity. In addition, mineral (BMD) scores lumbar spine (L-spine) femoral neck using same...