A5068875192- Psoriasis: Treatment and Pathogenesis
- Dermatology and Skin Diseases
- Autoimmune Bullous Skin Diseases
- Antifungal resistance and susceptibility
- Spondyloarthritis Studies and Treatments
- Asthma and respiratory diseases
- Gut microbiota and health
- Autoimmune and Inflammatory Disorders Research
- Rheumatoid Arthritis Research and Therapies
- Plant Stress Responses and Tolerance
- COVID-19 Clinical Research Studies
- Seed Germination and Physiology
- Long-Term Effects of COVID-19
- Mast cells and histamine
- Immunodeficiency and Autoimmune Disorders
- Cytokine Signaling Pathways and Interactions
- Eosinophilic Disorders and Syndromes
- Plant responses to elevated CO2
- Allergic Rhinitis and Sensitization
- T-cell and B-cell Immunology
- SARS-CoV-2 and COVID-19 Research
- IL-33, ST2, and ILC Pathways
- Light effects on plants
- Ion Transport and Channel Regulation
- Acne and Rosacea Treatments and Effects
New York University
2020-2024
Beijing University of Agriculture
2022-2024
University of Wisconsin–Madison
2024
NYU Langone Health
2019-2023
GlaxoSmithKline (India)
2021
AstraZeneca (Brazil)
2021
Pfizer (United Kingdom)
2021
Sanofi (Mexico)
2021
Amgen (United States)
2021
National Institute of Arthritis and Musculoskeletal and Skin Diseases
2021
Covid-19 in Immune-Mediated Inflammatory Diseases The authors describe patients New York City with known immune-mediated inflammatory disease whom developed while they were receiving...
Psoriasis impacts 1-3% of the world's population and is characterized by hyper-proliferation keratinocytes increased inflammation. At molecular level, psoriasis commonly driven a Th17 response, which serves as major therapeutic target. Microbiome perturbations have been associated with several immune-mediated diseases such atopic dermatitis, asthma, multiple sclerosis. Although few studies investigated association between skin microbiome psoriasis, conflicting results reported plausibly due...
Whereas the cellular and molecular features of human inflammatory skin diseases are well characterized, their tissue context systemic impact remain poorly understood. We thus profiled psoriasis (PsO) as a prototypic immune-mediated condition with high predilection for extracutaneous involvement. Spatial transcriptomics (ST) analyses 25 healthy, active lesion, clinically uninvolved biopsies integration public single-cell data revealed marked differences in immune microniches between healthy...
Objective To characterize the hospitalization and death rates among patients with inflammatory arthritis (IA) affected by coronavirus disease 2019 (COVID-19) to analyze associations of comorbidities immunomodulatory medications infection outcomes. Methods Data on clinical demographic features, maintenance treatment, course, outcomes in individuals IA (rheumatoid spondyloarthritis) symptomatic COVID-19 were prospectively assessed via web-based questionnaire followed individual phone calls...
Psoriasis patients demonstrate high interest in the role of diet on their skin condition. However, data are lacking to describe dietary interventions among psoriasis and associated outcomes. This study aims identify common habits, perceptions with psoriasis, examine patient-reported outcomes response these interventions. We administered a 61-question survey National Foundation membership asking about modifications, responses, perceptions. A total 1206 responded survey. Compared age-...
Melatonin (MT) can effectively reduce oxidative damage induced by abiotic stresses such as salt in plants. However, the effects of MT on physiological responses and molecular regulation during wheat germination remains largely elusive. In this study, response seeds to under stress was investigated at transcriptome levels. Our results revealed that application significantly reduced negative influence seed germination. The load inducing high activities antioxidant enzymes. parallel, content...
Salt stress caused by high concentrations of Na
The role of melatonin in plant growth and response to environmental stress has been widely demonstrated. However, the physiological molecular regulation salt tolerance wheat seedlings by remains unclear. In this study, we investigated changes phenotype, physiology, photosynthetic parameters, transcript levels reveal wheat. results indicate that application exogenous significantly alleviates inhibition, reactive oxygen species accumulation, membrane oxidative damage induced Additionally,...
Abstract: Metabolomics is an emerging new "omics" field involving the systematic analysis of metabolites in a biologic system. These provide molecular snapshot cellular activity and are thus important for understanding functional changes metabolic pathways that drive disease. Recently, metabolomics has been used to study local systemic psoriasis its cardiometabolic comorbidities. Such studies have revealed novel insights into disease pathogenesis suggest biochemical signatures may be as...
Skin of colored patients with psoriasis are more likely to remain undiagnosed and experience a greater impact on quality life than their white counterparts. A better understanding the ethno-racial differences in presentation can help address these disparities. To compare prevalence psoriatic subtypes (plaque, guttate, pustular, erythrodermic, palmoplantar, inverse) lesion locations Caucasian, Asian, Hispanic/Latino patients, we analyzed cross-sectional, patient-reported, physician-reviewed...
Patients with atopic dermatitis (AD) commonly turn to dietary modifications manage their skin condition.To investigate patient-reported outcomes and perceptions regarding the role of diet in AD.One hundred sixty nine AD patients were surveyed this cross-sectional study. The 61-question survey asked about modifications, outcomes.Eighty seven percent participants reported a trial exclusion. most common junk foods (68%), dairy (49.7%) gluten (49%). best improvement was when removing white flour...
Abstract It has long been recognized that anatomic location is an important feature for defining distinct subtypes of plaque psoriasis. However, little known about the molecular differences between scalp, palmoplantar, and conventional To investigate heterogeneity these psoriasis subtypes, we performed RNA-seq flow cytometry on skin samples from individuals with psoriasis, along healthy control patients. We differential expression analysis network using weighted gene coexpression (WGCNA)....
Psoriatic arthritis (PsA) is a chronic, inflammatory that affects an estimated 30% of patients with psoriasis. PsA underdiagnosed in primary care and dermatology clinics due to variety reasons, including failure healthcare providers ask about symptoms, overlap symptoms signs other rheumatologic conditions, lack specific diagnostic test. A delay diagnosis treatment, even as short 6 months, can lead decreased quality life, increased joint damage, worse long-term physical function. In this...
Psoriatic disease remains underdiagnosed and undertreated. We developed validated a suite of novel, sensor-based smartphone assessments (Psorcast app) that can be self-administered to measure cutaneous musculoskeletal signs symptoms psoriatic disease. Participants with psoriasis (PsO) or arthritis (PsA) healthy controls were recruited between June 5, 2019, November 10, 2021, at 2 academic medical centers. Concordance accuracy digital measures image-based machine learning models compared...