A5080001496- Nonmelanoma Skin Cancer Studies
- Cutaneous Melanoma Detection and Management
- Cutaneous lymphoproliferative disorders research
- Immunotherapy and Immune Responses
- Cancer and Skin Lesions
- Reconstructive Facial Surgery Techniques
- Polyomavirus and related diseases
- Reconstructive Surgery and Microvascular Techniques
- Cancer Immunotherapy and Biomarkers
- CAR-T cell therapy research
- Hedgehog Signaling Pathway Studies
- Nail Diseases and Treatments
- Infectious Diseases and Mycology
- Skin Protection and Aging
- T-cell and B-cell Immunology
- Tumors and Oncological Cases
- Dermatology and Skin Diseases
- Single-cell and spatial transcriptomics
- Allergic Rhinitis and Sensitization
- Immune Cell Function and Interaction
- RNA Interference and Gene Delivery
- AI in cancer detection
- Psoriasis: Treatment and Pathogenesis
- Cell Image Analysis Techniques
- Full-Duplex Wireless Communications
New York University
2016-2025
NYU Langone Health
2015-2024
Dermatology Foundation
2024
Indiana University School of Medicine
2023
Ramapo College
2023
Creative Commons
2023
Rockefeller University
2012-2020
American College
2019
Faculty of 1000 (United States)
2015
University School
2015
The classical Th1/Th2 paradigm previously defining atopic dermatitis (AD) and psoriasis has recently been challenged with the discovery of Th17 T cells that synthesize IL-17 IL-22. Although it is becoming evident many Th1 diseases including have a strong signal, importance in AD still unclear. We examined compared skin biopsies from patients by gene microarray, RT-PCR, immunohistochemistry, immunofluorescence. found reduced genomic expression IL-23, IL-17, IFN-gamma psoriasis. To define...
Whereas the cellular and molecular features of human inflammatory skin diseases are well characterized, their tissue context systemic impact remain poorly understood. We thus profiled psoriasis (PsO) as a prototypic immune-mediated condition with high predilection for extracutaneous involvement. Spatial transcriptomics (ST) analyses 25 healthy, active lesion, clinically uninvolved biopsies integration public single-cell data revealed marked differences in immune microniches between healthy...
IL-22 is a cytokine that acts mainly on epithelial cells. In the skin, it mediates keratinocyte proliferation and epidermal hyperplasia thought to play central role in inflammatory diseases with marked acanthosis, such as psoriasis. Although was initially considered Th17 cytokine, increasing evidence suggests T helper cells can produce even without IL-17 expression. addition, we have shown existence of this unique IL-22-producing cell normal skin psoriasis atopic dermatitis patients. present...
<h3>Importance</h3> Limited therapies are available in patients with inoperable locally advanced cutaneous squamous cell carcinoma (cSCC). <h3>Objective</h3> To determine the efficacy of programmed death 1 receptor (PD-1) inhibitors cSCC. <h3>Design, Setting, and Participants</h3> A single patient cSCC who declined surgery radiotherapy underwent treatment pembrolizumab, an anti–PD-1 antibody, at academic dermatologic section cancer center. The was followed up for clinical radiologic...
Solid-organ transplant recipients have a high incidence of cutaneous squamous cell carcinoma (SCC) and often develop multiple aggressive tumors. There are few published studies or reviews, which provide guidance to the clinician in treatment these patients.The objective was useful clinical guidelines for skin cancer organ (OTRs).The members Guidelines Committee International Transplant-Skin Cancer Collaborative (ITSCC) carried out computerized search utilizing databases National Library...
Immune suppressed organ transplant recipients suffer increased morbidity and mortality from primary cutaneous SCC. We studied tumor microenvironment in transplant-associated SCC (TSCC), immune-competent normal skin by IHC, IF RT-PCR on surgical discard. determined T cell polarization TSCC intracellular cytokine staining of crawl outs human explants. the effects IL-22, an inducer keratinocyte proliferation, proliferation vitro. are both associated with significantly higher numbers CD3+ CD8+...
Abstract These studies were performed to establish whether functional receptors for calcitonin gene-related peptide (CGRP) are present on human dendritic cells (DCs) and investigate potential immunomodulatory effects of CGRP DCs other than Langerhans cells. Reverse transcriptase-PCR revealed expression mRNA a type 1 receptor by mature immature blood-derived DCs. Sequence analysis confirmed the identity (CGRP-R1). Addition (10−7 M) resulted in mobilization intracellular calcium. Treatment...
BACKGROUND In-transit metastases from cutaneous squamous cell carcinoma (SCC) may occur in organ transplant recipients and indicate aggressive disease poor prognosis. OBJECTIVE The objective of this study was to describe in-transit SCC identify factors associated with phenomenon a series 21 patients. We also attempted evaluate outcome respect status as an recipient or nonorgan recipient. METHODS A multicenter case patients reviewed; included clinical presentation, management, outcome....
There is a paucity of evidence to guide physicians regarding prevention strategies for cutaneous squamous cell carcinoma (CSCC) in solid organ transplant recipients (SOTRs).To examine the development and results Delphi process initiated identify consensus-based medical management recommendations CSCC SOTRs.Dermatologists with more than 5 years' experience treating SOTRs were invited participate. A novel actinic damage skin cancer index (AD-SCI), consisting 6 ordinal stages corresponding an...