A5083298021- Systemic Lupus Erythematosus Research
- Renal Diseases and Glomerulopathies
- Chronic Lymphocytic Leukemia Research
- Atherosclerosis and Cardiovascular Diseases
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Systemic Sclerosis and Related Diseases
- Genetic Associations and Epidemiology
- T-cell and B-cell Immunology
- Diversity and Career in Medicine
- Inflammatory Bowel Disease
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Diabetes and associated disorders
- Vaccine Coverage and Hesitancy
- Chronic Kidney Disease and Diabetes
- Liver Disease Diagnosis and Treatment
- Chronic Myeloid Leukemia Treatments
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Long-Term Effects of COVID-19
- Healthcare cost, quality, practices
- Reproductive Health and Contraception
- Otitis Media and Relapsing Polychondritis
- Lysosomal Storage Disorders Research
- Monoclonal and Polyclonal Antibodies Research
- Air Quality and Health Impacts
University of Maryland, Baltimore
2024-2025
Hospital for Special Surgery
2022-2024
New York University
2017-2023
Cornell University
2022-2023
Evanston Hospital
2022
NYU Langone Health
2020-2021
Philadelphia College of Osteopathic Medicine
2020
University of Ghana
2020
Long Island University
2020
Hinge Health
2020
To evaluate seroreactivity and disease flares after COVID-19 vaccination in a multiethnic/multiracial cohort of patients with systemic lupus erythematosus (SLE). Ninety SLE 20 healthy controls receiving complete vaccine regimen were included. IgG to the SARS-CoV-2 spike receptor-binding domain (RBD) microneutralization used B cell responses; interferon-γ (IFNγ) production was measured by enzyme-linked immunospot (ELISpot) assay order assess T responses. Disease activity hybrid Activity Index...
Objective To characterize patients with systemic lupus erythematosus (SLE) affected by coronavirus disease 2019 (COVID‐19) and to analyze associations of comorbidities medications on infection outcomes. Methods Patients SLE reverse transcriptase–polymerase chain reaction–confirmed COVID‐19 were identified through an established New York University cohort, query 2 hospital systems, referrals from rheumatologists. Data prospectively collected via a web‐based questionnaire review medical...
Abstract Systemic autoimmune rheumatic diseases (SARDs) can lead to irreversible damage if left untreated, yet these patients often endure long diagnostic journeys before being diagnosed and treated. Machine learning may help overcome the challenges of diagnosing SARDs inform clinical decision-making. Here, we developed tested a machine model identify who should receive rheumatological evaluation for using longitudinal electronic health records 161,584 individuals from two institutions. The...
The Systemic Lupus International Collaborating Clinics (SLICC) is an international research group dedicated to promoting collaboration among scientific investigators in the study of systemic lupus erythematosus (SLE). Currently, most SLICC members are based North America and Europe, with limited representation from other regions. recognises importance expanding its global collaborations ensure that accurately reflects burden SLE provides equal benefit all patients worldwide. Given currently...
Objective Two apolipoprotein L1 ( APOL1 ) risk variants (RV) are enriched in sub-Saharan African populations due to conferred resistance Trypanosoma brucei . These associate with adverse renal outcomes by multiple causes including SLE. Despite emerging reports that SLE is common Ghana, where variant allelic frequencies high, the regional contribution has not been described. Accordingly, this prospective longitudinal cohort study tested associations between high-risk genotypes and kidney...
Atherosclerosis is exaggerated in African American (AA) systemic lupus erythematosus (SLE) patients, with doubled cardiovascular disease (CVD) risk compared to White patients. The extent which common Apolipoprotein L1 (APOL1) alleles (RA) contribute this trend unknown. This retrospective cohort study assessed prevalent atherosclerotic across APOL1 genotypes AA SLE patients.One hundred thirteen subjects were APOL1-genotyped and stratified as having: zero alleles, one allele, or two alleles....
Polymorphisms in the Apolipoprotein L1 ( APOL1 ) gene are common ancestrally African populations, and associate with kidney injury cardiovascular disease. These risk variants (RV) provide an advantage resisting Trypanosoma brucei , causal agent of trypanosomiasis, largely absent from non-African genomes. Clinical associations between high genotype (HRG) disease stronger those comorbid infectious or immune To understand interaction cytokine exposure cytotoxicity, we established human...
Non-White people are more likely to develop systemic lupus erythematosus (SLE) yet underrepresented in SLE clinical trials. The efficacy and safety of drugs may be influenced by ancestry, ancestrally diverse study populations necessary optimize treatments across the full spectrum patients. However, barriers entry into trials amplified non-White populations. To address these issues, a conference was held Bethesda, Maryland, from October 15-16, 2019, entitled "Increasing Ancestral Diversity...
Findings from cross-sectional studies have revealed associations between DNA methylation and systemic lupus erythematosus (SLE) outcomes. This study was undertaken to investigate the dynamics of by examining participants an SLE longitudinal cohort using samples collected at 2 time points.
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<h3>Background/Purpose</h3> Systemic Lupus Erythematosus (SLE) is more common and severe in those of African Ancestry (AA) who, relative to Europeans, are twice as likely develop lupus nephritis (LN).<sup>1</sup> Early detection can improve outcomes; however, current strategies rely on clinically apparent kidney injury invasive biopsies, representing a barrier care socioeconomically marginalized patients.<sup>2</sup> Urine sediment, which contains invading immune cells, offers conveniently...
The study objective was to prioritize topics for future patient-centered research increase uptake of common vaccines, such as pneumococcal pneumonia, influenza, herpes zoster, human papillomavirus, and severe acute respiratory syndrome coronavirus 2, among adults living with autoimmune conditions.A steering committee (SC) formed that included clinicians, patients, patient advocates, researchers associated rheumatic diseases (psoriatic arthritis, rheumatoid vasculitis), inflammatory bowel...
Background/purpose African Americans (AA) with systemic lupus erythematosus (SLE) are at higher risk for both kidney disease and Osteonecrosis (ON). Two Apolipoprotein L1 (APOL1) variants (RV), G1 G2, have been associated chronic (CKD), hypertension, microvascular in AAs, which independent factors ON. Accordingly, we investigated the association between carriers of APOL1 prevalence ON AA SLE patients. Methods A cohort 121 adult participants self-reported ancestry meeting least four American...
Objective There is a need to characterize exposures associated with the pathogenesis of systemic lupus erythematosus (SLE). In this pilot study, we explore hypothesis‐free approach that can measure thousands exogenous chemicals in blood (“exposome”) patients SLE and unaffected controls. Methods This cross‐sectional study analyzed cohort prevalent (n = 285) controls 106). Plasma was by liquid chromatography–quadrupole time‐of‐flight mass spectrometry (LC‐QTOF/MS). Mass features present at...