A5007400614- Inflammatory Bowel Disease
- Microscopic Colitis
- Adolescent and Pediatric Healthcare
- Eosinophilic Esophagitis
- Pregnancy and Medication Impact
- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Autoimmune and Inflammatory Disorders Research
- COVID-19 and healthcare impacts
- Childhood Cancer Survivors' Quality of Life
- Health Systems, Economic Evaluations, Quality of Life
- Immunodeficiency and Autoimmune Disorders
- Pharmaceutical studies and practices
- Colorectal Cancer Screening and Detection
- Celiac Disease Research and Management
- Diverticular Disease and Complications
- Intestinal Malrotation and Obstruction Disorders
- Vaccine Coverage and Hesitancy
- Systemic Lupus Erythematosus Research
- Helicobacter pylori-related gastroenterology studies
- Tuberculosis Research and Epidemiology
- Autoimmune and Inflammatory Disorders
- Gastrointestinal motility and disorders
- Acute Lymphoblastic Leukemia research
- Pancreatitis Pathology and Treatment
University of North Carolina at Chapel Hill
2016-2025
Patient-Centered Outcomes Research Institute
2023-2024
Dayton Children's Hospital
2023
Cincinnati Children's Hospital Medical Center
2014-2022
University of North Carolina Health Care
2009-2022
Children's Hospital Colorado
2022
University of Colorado Denver
2022
Johns Hopkins University
2022
Mount Sinai Health System
2022
Ochsner Health System
2022
Most US inflammatory bowel disease (IBD) epidemiology studies conducted to date have sampled small, geographically restricted populations and not examined time trends. The aim of our study was determine the prevalence Crohn's (CD) ulcerative colitis (UC) in a commercially insured population compare prevalences across sociodemographic characteristics time.Using claims data from approximately 12 million Americans, we performed three consecutive 2-year cross-sectional studies. Cases CD UC were...
Clonidine and ICI 106270 are centrally acting antihypertensive agents which act through stimulation of medullary alpha-2 adrenoceptors. Both compounds equipotent agonists at adrenoceptors as assessed in functional studies isolated organs radioligand binding studies. In addition, clonidine possess the same degree selectivity for over alpha-1 after intracisternal administration to spontaneously hypertensive rats, consistent with observations made vitro that both adrenoceptor agonists. were...
We sought to evaluate COVID-19 clinical course in patients with IBD treated different medication classes and combinations.
ABSTRACT Objectives: Eosinophilic esophagitis (EoE) is becoming increasingly more common, but the prevalence of other eosinophilic gastrointestinal disorders (EGIDs) unknown. Our objective was to estimate gastritis, gastroenteritis, and colitis in United States. Methods: We used IMS Health LifeLink PharMetrics Plus Claims Database, data representative a US national commercially insured population containing medical pharmaceutical claims for >75 million individuals. restricted our sample...
The International Organization for the Study of Inflammatory Bowel Diseases (IOIBD) is only global organization devoted to study and management inflammatory bowel diseases (IBDs), namely, Crohn's disease ulcerative colitis. Membership composed physician-scientists who have established expertise in these diseases. hosts an annual meeting a number working groups addressing issues epidemiology IBD, diet nutrition, development use treatments IBD. There are currently 89 members IOIBD representing...
Cardiac complications, particularly myocarditis and pericarditis, have been associated with SARS-CoV-2 (the virus that causes COVID-19) infection (1-3) mRNA COVID-19 vaccination (2-5). Multisystem inflammatory syndrome (MIS) is a rare but serious complication of frequent cardiac involvement (6). Using electronic health record (EHR) data from 40 U.S. care systems during January 1, 2021-January 31, 2022, investigators calculated incidences outcomes (myocarditis; or pericarditis; myocarditis,...
Obesity is a significant public health threat to children in the United States. The aims were to: 1) Determine prevalence of obesity multicenter cohort with inflammatory bowel disease (IBD); 2) Evaluate whether overweight and obese status associated patient demographics or characteristics.We used data from ImproveCareNow Collaborative for pediatric IBD, registry collected between April 2007 December 2009. Children ages 2-18 years classified into body mass index (BMI) percentiles. Bivariate...
OBJECTIVES: Patients with inflammatory bowel disease (IBD) may be at increased risk for infections. We aimed to determine the pneumonia in IBD and how specific medications affect this risk. METHODS: performed a retrospective cohort nested case–control study using administrative data from IMS Health Inc., LifeLink Plan Claims Database. Limitations set include lack of clinical details validate exposures outcomes. In cohort, patients were matched four individuals without IBD. Pneumonia was...
Unintended variation in the care of patients with Crohn disease (CD) and ulcerative colitis (UC) may prevent achievement optimal outcomes. We sought to improve chronic delivery outcomes for children inflammatory bowel by using network-based quality improvement methods.By a modified Breakthrough Series collaborative structure, 6 ImproveCareNow Network centers tested changes illness collected data monthly. used an interrupted time series design evaluate impact these changes.Data were available...
ABSTRACT Objectives: Few etiologic studies of eosinophilic esophagitis (EoE) have been conducted. Early life exposures shown to predispose other allergic disease, but their role has not assessed in EoE. The present study sought explore early as possible risk factors for developing EoE the pediatric population. Methods: This was a 2‐phase case‐control conducted at University North Carolina. first phase consisted survey development via cognitive interview. In second phase, telephone‐based...