A5023154420- Inflammatory Bowel Disease
- Microscopic Colitis
- Immunodeficiency and Autoimmune Disorders
- Adolescent and Pediatric Healthcare
- Gut microbiota and health
- Eosinophilic Esophagitis
- Helicobacter pylori-related gastroenterology studies
- Autoimmune and Inflammatory Disorders Research
- Pharmaceutical studies and practices
- Intestinal Malrotation and Obstruction Disorders
- Clostridium difficile and Clostridium perfringens research
- IL-33, ST2, and ILC Pathways
- Childhood Cancer Survivors' Quality of Life
- Acute Lymphoblastic Leukemia research
- Gastrointestinal motility and disorders
- Autoimmune and Inflammatory Disorders
- Gastrointestinal disorders and treatments
- Diverticular Disease and Complications
- Celiac Disease Research and Management
- Liver Diseases and Immunity
- Viral gastroenteritis research and epidemiology
- Pregnancy and Medication Impact
- Clinical Nutrition and Gastroenterology
- Mycobacterium research and diagnosis
- Immune Cell Function and Interaction
Children's Hospital of Philadelphia
2016-2025
University of Pennsylvania
2016-2025
Philadelphia University
2004-2024
Morgan Stanley Children's Hospital
2020
California University of Pennsylvania
1989-2019
University of Toronto
2018
Hospital for Sick Children
2018
SickKids Foundation
2018
Boston Children's Hospital
2018
Temple University Health System
2017
Diet strongly affects human health, partly by modulating gut microbiome composition. We used diet inventories and 16S rDNA sequencing to characterize fecal samples from 98 individuals. Fecal communities clustered into enterotypes distinguished primarily levels of Bacteroides Prevotella. Enterotypes were associated with long-term diets, particularly protein animal fat (Bacteroides) versus carbohydrates (Prevotella). A controlled-feeding study 10 subjects showed that composition changed...
Studies of pediatric inflammatory bowel disease (IBD) have varied in the criteria used to classify patients as having Crohn (CD), ulcerative colitis (UC), or indeterminate (IC). Patients undergoing an initial evaluation for IBD will often undergo a series diagnostic tests, including barium upper gastrointestinal with small follow-through, abdominal CT, endoscopy, and colonoscopy biopsies. Other tests performed less frequently include magnetic resonance imaging scans, serological testing,...
Several probiotic compounds have shown promise in the therapy of ulcerative colitis (UC). However, a strong sustained benefit remains to be seen. Uncontrolled pilot studies suggest that preparation (VSL#3) maintains remission mild moderate UC and reduces active inflammation adult patients. Aims our prospective, 1-year, placebo-controlled, double-blind study were assess efficacy VSL#3 on induction maintenance evaluate safety tolerability children with UC.A total 29 consecutive patients (mean...
Interactions between the host and gut microbial community likely contribute to Crohn disease (CD) pathogenesis; however, direct evidence for these interactions at onset of is lacking. Here, we characterized global pattern ileal gene expression in 359 treatment-naive pediatric patients with CD, ulcerative colitis (UC), control individuals. We identified core profiles communities affected CD ilea that are preserved unaffected colon-only but not present those UC or individuals; therefore, this...
Inflammatory CD4(+) T cell responses to self or commensal bacteria underlie the pathogenesis of autoimmunity and inflammatory bowel disease (IBD), respectively. Although selection self-specific cells in thymus limits mammalian tissue antigens, mechanisms that control bacteria-specific remain poorly understood. Here, we demonstrate group 3 innate lymphoid (ILC3)-intrinsic expression major histocompatibility complex class II (MHCII) is regulated similarly thymic epithelial MHCII(+) ILC3s...
Probiotics are widely used by patients with Crohn's disease (CD) in an attempt to improve their health, but few controlled studies have been done evaluate the efficacy of these therapies. We conducted a randomized, placebo-controlled trial probiotic Lactobacillus rhamnosus strain GG (LGG) see if addition LGG standard therapy prolonged remission children CD. Concomitant medications allowed study included aminosalicylates, 6-mercaptopurine, azathioprine, and low-dose alternate day...
Abstract Molecular mechanisms driving disease course and response to therapy in ulcerative colitis (UC) are not well understood. Here, we use RNAseq define pre-treatment rectal gene expression, fecal microbiota profiles, 206 pediatric UC patients receiving standardised therapy. We validate our key findings adult paediatric cohorts of 408 participants. observe a marked suppression mitochondrial genes function across active UC, that increasing severity is notable for enrichment...