A5027245804- Inflammatory Bowel Disease
- Microscopic Colitis
- Eosinophilic Esophagitis
- Diverticular Disease and Complications
- Adolescent and Pediatric Healthcare
- Autoimmune and Inflammatory Disorders
- Oral Health Pathology and Treatment
- Sinusitis and nasal conditions
- Genetic and Kidney Cyst Diseases
- Celiac Disease Research and Management
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- RNA and protein synthesis mechanisms
- Diagnosis and treatment of tuberculosis
- Advanced biosensing and bioanalysis techniques
- Obstructive Sleep Apnea Research
- Bacterial Genetics and Biotechnology
- Intestinal Malrotation and Obstruction Disorders
- Enhanced Recovery After Surgery
- Liver Diseases and Immunity
- RNA modifications and cancer
- Helicobacter pylori-related gastroenterology studies
- Gastrointestinal disorders and treatments
- Mycobacterium research and diagnosis
- Atherosclerosis and Cardiovascular Diseases
- Stoma care and complications
University of Chicago
2019-2024
Yale University
2021-2024
Western University of Health Sciences
2023
Crohn's and Colitis Foundation
2022
University of Mysore
2022
University of Michigan
2014-2019
Analysis Group (United States)
2014-2018
All India Institute of Medical Sciences
2014
The International Organization for the Study of Inflammatory Bowel Diseases (IOIBD) is only global organization devoted to study and management inflammatory bowel diseases (IBDs), namely, Crohn's disease ulcerative colitis. Membership composed physician-scientists who have established expertise in these diseases. hosts an annual meeting a number working groups addressing issues epidemiology IBD, diet nutrition, development use treatments IBD. There are currently 89 members IOIBD representing...
The COVID-19 pandemic has claimed the lives of nearly 2 million people worldwide.1 Following rapid sequencing SARS-CoV-2, pharmaceutical companies and academic institutions rapidly generated vaccine candidates on back a variety both established novel platforms.2–4 Vaccines accelerated at unprecedented pace to phase 3 development, in December 2020, two mRNA vaccines one inactivated were authorised for use number countries. Additional platforms are late stages testing.5 Prioritisation access...
Abstract Autosomal dominant polycystic kidney disease (ADPKD) is the most prevalent potentially lethal monogenic disorder. Mutations in PKD1 gene, which encodes polycystin-1 (PC1), account for approximately 78% of cases. PC1 a large 462-kDa protein that undergoes cleavage its N and C-terminal domains. produces fragments translocate to mitochondria. We show transgenic expression corresponding final 200 amino acid (aa) residues two Pkd1 -KO orthologous murine models ADPKD suppresses cystic...
Summary Background Following induction therapy with a calcineurin inhibitor (CNI) in severe ulcerative colitis, transitioning to vedolizumab as maintenance could be an option. Aim To report on the largest cohort of patients successfully induced CNIs who were transitioned therapy. Methods This is retrospective observational study adult steroid‐refractory colitis. Patients included if they CNI followed by between January 2014 and December 2018. The primary endpoint was colectomy‐free survival....
Abstract Background Chronic inflammation in ulcerative colitis (UC) is associated with the development of colorectal neoplasia (CRN). A group at St. Mark’s Hospital reported a novel cumulative inflammatory index that predicted CRN UC patients we validated an independent, well-described, matched, case-controlled cohort from University Chicago. Methods Cumulative burden (CIB) was calculated by summing each histological activity (HIA) score and multiplying it length surveillance interval....
Atherosclerosis is a chronic inflammatory disease and hypercholesterolemia risk factor. This study aims to compare the potency of lipopolysaccharide (LPS) oxidized low-density lipoproteins (oxLDL) induce plaque formation increase vulnerability in carotid artery hypercholesterolemic Yucatan microswine. Atherosclerotic lesions at common junction ascending pharyngeal were induced microswine 5-6 months age with balloon angioplasty. LPS or oxLDL administered intraluminally site injury after...
Abstract Background Clinical trial recruitment for patients with inflammatory bowel disease [IBD] has become more challenging over time. We aimed to develop recommendations broadening IBD clinical eligibility, improve the inclusion of a representative patient population in efficient timeline. Methods applied RAND/UCLA Appropriateness Method, focused on eligibility. A literature review was performed seven domains, each representing different area related recruitment. Based these 32 statements...
Background: Malignant middle cerebral artery (MCA) infarction is associated with high mortality and morbidity. Decompressive hemicraniectomy (DH) reduces significantly but evidence for long-term functional benefit sparse contradictory. Materials Methods: A total of 60 patients malignant MCA were prospectively enrolled. 36 (60%) underwent DH 24 (40%) received best medical therapy alone. Both groups followed-up 1 year improvement in disability aphasia using modified Rankin score (mRS) Western...
Despite significant differences in surgical outcomes between pediatric and adult patients with ulcerative colitis (UC) undergoing colectomy, counseling on has largely been guided by data from adults. We compared pouch survival who underwent total proctocolectomy ileal pouch-anal anastomosis (IPAA).
Abstract Background Patients with inflammatory bowel disease (IBD) who undergo proctocolectomy ileal pouch–anal anastomosis may develop pouchitis. We previously proposed a novel endoscopic classification of pouchitis describing 7 phenotypes differing outcomes. This study assessed phenotype transitions over time. Methods classified pouch findings into main phenotypes: (1) normal, (2) afferent limb (AL) involvement, (3) inlet (IL) (4) diffuse, (5) focal inflammation the body, (6) cuffitis, and...
Abstract We have previously demonstrated that histological normalization in ulcerative colitis (UC) is associated with superior maintenance of remission outcomes. This single-center, retrospective case-control study assessed outcomes after the therapeutic de-escalation UC patients who achieved histologic normalization. A total 111 were included, which 24 underwent de-escalation, and 87 without changes. The most commonly withdrawn therapy was aminosalicylates (50%), followed by...
Complete histologic normalization is associated with improved clinical outcomes in ulcerative colitis (UC). However, it currently unknown what effect achieving has on the development of dysplasia.We performed a retrospective analysis 495 patients confirmed diagnosis UC from tertiary center. Patients were categorized according to best assessment they had during their disease course: normalization, quiescence, or persistent activity. We assessed dysplasia rates these patient groups after 8...
The ability to control transcription in a time-dependent manner vitro promises numerous applications molecular biology and nanotechnology. Here we demonstrate an approach that enables precise, independent over the production of multiple RNA transcripts using single guide (sgRNA)-directed blockades by catalytically dead Streptococcus pyogenes CRISPR-Cas9 enzyme (dCas9). We show when bound DNA template, dCas9:sgRNA complex forms robust blockade polymerases (RNAPs) from bacteriophages SP6, T3,...
Abstract Background The modified pouchitis disease activity index (mPDAI) based on clinical symptoms and endoscopic findings is used to diagnose pouchitis, but validated instruments monitor are still lacking. We recently established an classification that described 7 phenotypes with different outcomes. assessed compared mPDAIs among in inflammatory bowel (IBD). Methods retrospectively reviewed pouchoscopies classified them into main phenotypes: normal (n = 25), afferent limb (AL) involvement...
Abstract Background Although validated patient-reported outcome (PRO) measurements can categorize patients with inflammatory bowel disease (IBD) into clinical remission or active disease, may have different definitions of remission. The purpose this study was to compare patient-defined based on PRO measures and physician global assessment (PGA) understand the demographic factors associated disagreements. Methods We retrospectively analyzed 3257 de-identified surveys from 2004 IBD who...