Joel R. Rosh
A5064024135- Inflammatory Bowel Disease
- Microscopic Colitis
- Adolescent and Pediatric Healthcare
- Immunodeficiency and Autoimmune Disorders
- Eosinophilic Esophagitis
- Autoimmune and Inflammatory Disorders Research
- Pharmaceutical studies and practices
- Helicobacter pylori-related gastroenterology studies
- Intestinal Malrotation and Obstruction Disorders
- Liver Diseases and Immunity
- Acute Lymphoblastic Leukemia research
- Pregnancy and Medication Impact
- Gastrointestinal disorders and treatments
- Pediatric Hepatobiliary Diseases and Treatments
- Pediatric Pain Management Techniques
- Autoimmune and Inflammatory Disorders
- Celiac Disease Research and Management
- Colorectal Cancer Screening and Detection
- Gut microbiota and health
- Gastrointestinal motility and disorders
- Liver Disease Diagnosis and Treatment
- Diverticular Disease and Complications
- Childhood Cancer Survivors' Quality of Life
- Gastroesophageal reflux and treatments
- Esophageal and GI Pathology
Atlantic Health System
2003-2025
Children's Medical Center
2025
Cohen Children's Medical Center
2023-2024
Schneider Children's Hospital
2023-2024
Donald & Barbara Zucker School of Medicine at Hofstra/Northwell
2023-2024
Goryeb Children's Hospital
2014-2023
Northwell Health
2023
Icahn School of Medicine at Mount Sinai
1991-2021
Pfizer (United Kingdom)
2021
Janssen (Switzerland)
2021
Interactions between the host and gut microbial community likely contribute to Crohn disease (CD) pathogenesis; however, direct evidence for these interactions at onset of is lacking. Here, we characterized global pattern ileal gene expression in 359 treatment-naive pediatric patients with CD, ulcerative colitis (UC), control individuals. We identified core profiles communities affected CD ilea that are preserved unaffected colon-only but not present those UC or individuals; therefore, this...
Probiotics are widely used by patients with Crohn's disease (CD) in an attempt to improve their health, but few controlled studies have been done evaluate the efficacy of these therapies. We conducted a randomized, placebo-controlled trial probiotic Lactobacillus rhamnosus strain GG (LGG) see if addition LGG standard therapy prolonged remission children CD. Concomitant medications allowed study included aminosalicylates, 6-mercaptopurine, azathioprine, and low-dose alternate day...
BackgroundWe evaluated the psychometric performance of Pediatric Ulcerative Colitis Activity Index (PUCAI) in a real-life cohort from IBD Collaborative Research Group.
Abstract Molecular mechanisms driving disease course and response to therapy in ulcerative colitis (UC) are not well understood. Here, we use RNAseq define pre-treatment rectal gene expression, fecal microbiota profiles, 206 pediatric UC patients receiving standardised therapy. We validate our key findings adult paediatric cohorts of 408 participants. observe a marked suppression mitochondrial genes function across active UC, that increasing severity is notable for enrichment...
The International Organization for the Study of Inflammatory Bowel Diseases (IOIBD) is only global organization devoted to study and management inflammatory bowel diseases (IBDs), namely, Crohn's disease ulcerative colitis. Membership composed physician-scientists who have established expertise in these diseases. hosts an annual meeting a number working groups addressing issues epidemiology IBD, diet nutrition, development use treatments IBD. There are currently 89 members IOIBD representing...
ABSTRACT Background and Objectives: Longitudinal assessment of disease activity is necessary for studies therapeutic intervention in children with Crohn disease. The Pediatric Disease Activity Index (PCDAI) was developed a decade ago such purpose, but it function has only been examined small number limited patients. primary objectives the present study were to develop cut scores reflecting as determined by physician global (PGA) evaluate responsiveness PCDAI changes patient condition after...
OBJECTIVE. Children with chronic abdominal pain of nonorganic origin, termed functional (FAP), experience school absences and social withdrawal report impaired physical ability. The aim this study was to assess patients' parents' perceptions health-related quality life (QoL) for children FAP. METHODS. Between October 2002 November 2003, 209 (including 125 girls; age: 11.2 ± 3.5 years) parents were recruited from a pediatric referral center. At the time their initial evaluations, participants...
The objective of this study was to investigate the effect chronic constipation on children's quality life.From October 2002 November 2003, 224 children (140 male, 84 female, aged 10.6 +/- 2.9 years) and parents were evaluated by a health related life tool during initial outpatient consultation. Children with (n = 80) compared controls inflammatory bowel disease 42), gastroesophageal reflux 56), healthy 46).Children had lower scores than did those (70 versus 84; P < 0.05), 80; 88; 0.05)....
Infliximab therapy has short-term benefits in children with moderate-to-severe Crohn's disease (CD). We assessed the long-term outcome of infliximab maintenance CD.We performed a multicenter cohort study 729 pediatric patients CD enrolled Pediatric Inflammatory Bowel Disease Collaborative Research Group Registry. Children younger than 16 years and newly diagnosed were eligible for this study. medication information collected prospectively from treating physician at diagnosis, 30 days,...
Although it is known that extraintestinal manifestations (EIMs) commonly occur in pediatric inflammatory bowel disease (IBD), little research has examined rates of EIMs and their relation to other disease-related factors this population. The purpose study was determine the IBD examine correlations with age, sex, diagnosis, severity, distribution.Data were prospectively collected as part Pediatric Collaborative Research Group Registry, an observational database enrolling newly diagnosed...
OBJECTIVE. The goal was to determine how often common laboratory tests yield normal results at the time of diagnosis for children with inflammatory bowel disease. METHODS. Data were obtained from a registry newly diagnosed disease who enrolled prospectively in 18 US/Canadian centers. Laboratory values investigated included hemoglobin level, platelet count, albumin and erythrocyte sedimentation rate. Disease severity categorized by physician global assessment. RESULTS. A total 526 (mean age:...
We analyzed growth outcomes in children newly diagnosed with Crohn disease and determined whether abnormalities persist despite current therapies.Clinical data were prospectively obtained on an inception cohort younger than 16 years old at diagnosis Tanner I to III during the study.In all, 176 (mean age 10.1 years; 65% male) mild (33%) or moderate/severe (67%) studied. Disease activity 1 year was inactive/mild (89%) (11%). First-year treatments included immunomodulators (60%),...