A5084322545- Inflammatory Bowel Disease
- Microscopic Colitis
- Adolescent and Pediatric Healthcare
- Autoimmune and Inflammatory Disorders Research
- Eosinophilic Esophagitis
- Liver Disease and Transplantation
- Childhood Cancer Survivors' Quality of Life
- Immunodeficiency and Autoimmune Disorders
- Pharmaceutical studies and practices
- Acute Lymphoblastic Leukemia research
- Clinical Nutrition and Gastroenterology
- Child Nutrition and Feeding Issues
- Organ Transplantation Techniques and Outcomes
- Helicobacter pylori-related gastroenterology studies
- Liver Diseases and Immunity
- Pediatric Hepatobiliary Diseases and Treatments
- Gastrointestinal motility and disorders
- Liver Disease Diagnosis and Treatment
- Pregnancy and Medication Impact
- Gastroesophageal reflux and treatments
- Intestinal Malrotation and Obstruction Disorders
- Pediatric Pain Management Techniques
- Gastrointestinal disorders and treatments
- Infant Health and Development
- Metabolism and Genetic Disorders
Icahn School of Medicine at Mount Sinai
2016-2025
Goryeb Children's Hospital
2020
Children's Healthcare of Atlanta
2020
Emory University
2020
Sinai Hospital
1994-2019
University of North Carolina at Chapel Hill
2018
Hartford Financial Services (United States)
2014-2017
Mount Sinai Hospital
1991-2015
Mount Sinai Medical Center
1990-2011
Brooklyn College
2011
ABSTRACT Background: Ustekinumab is an effective therapy for Crohn disease currently approved adults. Off‐label use in the pediatric population increasing, but its effectiveness this age group has not been reported. Aims: The aim of study was to describe real‐world experience with ustekinumab at a tertiary care inflammatory bowel (IBD) center. Methods: As part ongoing observational cohort biologic‐treated IBD patients initiated October 2014, data on demographics, behavior, location and...
Adolescence is a vulnerable period for those afflicted with inflammatory bowel disease (IBD). There limited knowledge of factors influencing transition readiness in this population. We sought to determine whether self-efficacy and resilience would be informative predictors independent age. Patients IBD aged 16 23 years cared pediatric setting were prospectively enrolled. On entry, patients filled out the Transition Readiness Assessment Questionnaire (TRAQ); Self-Efficacy Scale—Adolescent...
Hyperammonemia, abnormalities in plasma amino acids and of standard liver functions were corrected by orthotopic transplantation a 14-day-old boy with carbamyl phosphate synthetase-I deficiency 35-yr-old man argininosuccinic acid synthetase deficiency. The first patient had high glutamine levels no measureable citrulline, whereas citrulline values markedly increased Patient 2. Enzyme analysis the original livers showed undetectable activity 1 arginosuccinic Both patients comatose before...
Infliximab (IFX) discontinuation is not uncommon during the first year of treatment due to inadequate drug concentrations and anti-IFX antibodies (ATI). Both combination therapy proactive therapeutic monitoring (pTDM) are used decrease ATI increase IFX durability. We proposed that monotherapy (Mono) as effective (Combo) if maintenance infusion dosed based on week 10 pTDM. In a retrospective cohort 83 patients with inflammatory bowel disease (IBD), we examined frequency discontinuation, ATI,...
Our goals were to answer 2 questions: (1) Is the presentation of early-onset inflammatory bowel disease (IBD) similar typical adolescent-onset IBD? (2) there variability in familial aggregation childhood IBD?The phenotype IBD children under 5 years age (early-onset) is poorly defined. Clinical and genetic studies IBD, however, generally assume be homogenous throughout childhood.We analyzed data from 413 consecutive pediatric outpatients attending our center between 1995 2000. Disease type,...
Background: Children and adolescents who seek medical treatment for persistent physical distress often suffer from co-occurring anxiety disorders. Treatment options this impaired population are limited. This study tests the feasibility potential efficacy of a cognitive-behavioral intervention targeting pain youth with impairing functional symptoms disorders presenting to pediatricians care. Methods: (aged 8–16) experiencing somatic complaints, without an explanatory disorder (i.e.,...
Epstein Barr virus (EBV) is a human herpes that infects 90% of the world's population and has been linked to development lymphoproliferative disorders (LPDs) immunosuppression. Primary EBV infection in patients with IBD on thiopurines risk factor for LPD, including lymphoma. We aimed describe status pediatric an emphasis those initiating thiopurines.Electronic medical records serologies were reviewed categorized into asymptomatic screening versus suspicion acute infection. before therapy was...
Liver transplantation is recognized as the appropriate treatment for end-stage liver disease due to chronic active autoimmune hepatitis. While it was initially thought that did not recur after transplant, now generally accepted adult patients may develop recurrent disease, with studies reporting a recurrence rate of < or = 25%. We have noted higher incidence hepatitis in our pediatric undergoing high associated morbidity.We reviewed records six children followed up who underwent orthotopic...
Purpose. Adolescents with inflammatory bowel disease (IBD) may be at heightened risk for developing anxiety and depression. This cross-sectional pilot study examined the relationship between depression health-related behaviors. Methods. Thirty-six adolescents diagnosed IBD, ages 12–17, their parents were recruited from two pediatric gastroenterology medical centers. Results. Clinical levels of (22%) depressive symptoms (30%) reported by patients. Regression analyses revealed that...
Crohn's disease (CD) is a chronic inflammatory of the gastrointestinal tract. Current medications have potentially serious side effects. Hence, there increasing interest in alternative therapies. We previously demonstrated anti-inflammatory effects Food Allergy Herbal Formula-2 vitro on peripheral blood mononuclear cells (PBMCs) and mucosa from CD subjects. Here, we investigated bioactive compound isolated Ganoderma lucidum (G. lucidum), key herbal constituent Formula-2, vitro.Triterpene...
ABSTRACT Objectives: Children and adolescents diagnosed as having Crohn disease (CD), a type of inflammatory bowel (IBD), have increased vulnerability for anxiety symptoms that may be related to disease‐related processes. The aims this article are 3‐fold: report the proportion pediatric patients with CD whose self‐reported indicative distress, describe constellation symptoms, examine relation between symptoms. Methods: Retrospective medical chart review was performed 93 youths (ages 9–18...
Abstract Background The incidence of very early onset inflammatory bowel disease (VEOIBD) is increasing, yet the phenotype and natural history VEOIBD are not well described. Methods We performed a retrospective cohort study patients diagnosed with (6 years age younger) between 2008 2013 at 25 North American centers. Eligible each center were randomly selected for chart review. abstracted data diagnosis 1, 3, 5 after diagnosis. compared clinical features outcomes younger than 3 children to 6...
INTRODUCTION: Obesity is common among patients with pediatric Crohn's disease (PCD). Some adult studies suggest obese respond less well to anti-tumor necrosis factor (TNF) treatment. This study sought compares anti-TNF response and levels between normal high body mass index (BMI). METHODS: The COMBINE trial compared monotherapy combination therapy methotrexate in PCD. In this secondary analysis, a comparison of time-to-treatment failure BMI vs Z -score >1, adjusting for prescribed...
NOD2/CARD15 variants have recently been shown to be associated with Crohn's disease (CD). No analysis of gene has so far reported in pediatric patients. Therefore, our aim was analyze children CD and perform genotype-phenotype analyses.We studied 101 136 healthy controls. Detailed phenotypic information obtained from each patient. Patients were genotyped for the three R702W (single nucleotide polymorphism 8 [SNP8]), G908R (SNP12), L1007fs (SNP13), correlations performed.We found 33 mutations...
Crohn's disease (CD) has the highest prevalence among individuals of Ashkenazi Jewish (AJ) descent compared to non-Jewish Caucasian populations (NJ). We evaluated a set well-established CD-susceptibility variants determine if they can explain increased CD risk in AJ population. recruited 369 patients and 503 controls, genotyped 22 single nucleotide polymorphisms (SNPs) at or near 10 CD-associated genes, NOD2, IL23R, IRGM, ATG16L1, PTGER4, NKX2-3, IL12B, PTPN2, TNFSF15 STAT3, assessed their...
Abstract Purpose To examine the feasibility and preliminary benefits of an integrative cognitive behavioral therapy ( CBT ) with adolescents inflammatory bowel disease anxiety. Design Methods Nine participated in a program at their gastroenterologist's office. Structured diagnostic interviews, self‐report measures anxiety pain, physician‐rated severity were collected pretreatment post‐treatment. Results Postintervention, 88% treatment responders, 50% no longer met criteria for principal...