A5023134328- Gastrointestinal motility and disorders
- Gastroesophageal reflux and treatments
- Inflammatory Bowel Disease
- Helicobacter pylori-related gastroenterology studies
- Congenital gastrointestinal and neural anomalies
- Gastrointestinal disorders and treatments
- Pancreatitis Pathology and Treatment
- Microscopic Colitis
- Intestinal Malrotation and Obstruction Disorders
- Eosinophilic Esophagitis
- Pediatric Hepatobiliary Diseases and Treatments
- Child Nutrition and Feeding Issues
- Autoimmune and Inflammatory Disorders Research
- Celiac Disease Research and Management
- Anorectal Disease Treatments and Outcomes
- Esophageal and GI Pathology
- Liver Disease and Transplantation
- Diverticular Disease and Complications
- Gallbladder and Bile Duct Disorders
- Colorectal Cancer Screening and Detection
- Adolescent and Pediatric Healthcare
- Hepatitis Viruses Studies and Epidemiology
- Abdominal vascular conditions and treatments
- Neonatal Health and Biochemistry
- Obesity, Physical Activity, Diet
Yale University
2015-2025
Yale New Haven Hospital
2016-2024
Fundación Juan March
2014-2015
Takeda (United States)
2011
Pediatrics and Genetics
2008-2009
University of Iowa
2001-2005
University of Iowa Hospitals and Clinics
2004
University of Iowa Stead Family Children’s Hospital
2000-2002
British Columbia Children's Hospital
1997-2002
Boston Children's Hospital
2002
<h3>Objectives</h3> To assess the clinical and biochemical safety profile of long-term polyethylene glycol 3350 (PEG) therapy in children with chronic constipation to pediatric patient acceptance PEG therapy. <h3>Design</h3> Prospective observational study. <h3>Setting</h3> Pediatric clinics at a referral center. <h3>Patients</h3> Eighty-three (44 constipation, 39 encopresis) receiving for more than 3 months. <h3>Main Outcome Measures</h3> Clinical adverse effects related compliance Serum...
OBJECTIVE. Our aim was to compare 2 laxatives, namely, polyethylene glycol 3350 without electrolytes and milk of magnesia, evaluating the efficacy, safety, acceptance, 1-year outcomes. METHODS. Seventy-nine children with chronic constipation fecal incontinence were assigned randomly receive or magnesia treated for 12 months in tertiary care pediatric clinics. Children counted as improved recovered depending on resolution constipation, incontinence, abdominal pain after 1, 3, 6, months. An...
Acute pancreatitis is a painful inflammatory disorder known to occur in children. Recent reports, primarily on the basis of adult data, have suggested an increasing incidence. However, pediatric studies are limited.The study was performed examine frequency acute population from 1994 2007 and characterize etiologies by age subsets.In this retrospective study, cases were identified ICD-9 codes subjected inclusion criteria.Two hundred seventy-one met criteria. Mean subjects 13.1 +/- 5.6 years....
The rapidly increasing prevalence of obesity in children is the most important problem facing pediatricians today. A recent study suggested an association and constipation but lacked a control group for comparison. objectives this were to evaluate large cohort with functional compare it representative general population.Retrospective chart review was performed on 719 children, between ages 4 <18 years, chronic seen pediatric gastroenterology clinics July 2002 June 2004. Data collected...
We aimed to examine correlation of erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) with diagnosis inflammatory bowel disease clinical, endoscopic, histological, radiographic activity during follow-up. reviewed charts 135 children correlated their ESR CRP values in various encounters 5 years. Normal were observed up 28% Crohn 42% ulcerative colitis at diagnosis, respectively. Correlation histologic follow-up depended on value mode analysis (continuous or dichotomous). Both...
Recent studies in adults report symptom relief with marijuana use patients inflammatory bowel disease (IBD). We assessed the prevalence, pattern, effects, and adverse effects of young IBD.We conducted a prospective questionnaire survey study at pediatric IBD clinic. All (18-21 years age) answered anonymous questionnaires about demographics, IBD, medications, use.Fifty-three (mean age 18.7 years, 32 boys) were enrolled. Thirty-seven (70%) reported using currently or past. There was no...
We have recently reported the safety and efficacy of polyethylene glycol 3350 without electrolytes (PEG) for daily treatment constipation in older children. Because there are very few data available on use PEG infants toddlers, we evaluated children <2 years age.This is a retrospective chart review 75 constipated age at start therapy. was started an average dose 1 g/kg body weight/d parents were asked to adjust yield 2 soft painless stools/d. Data from history physical examination collected...
Little is known about risk factors for biliary pancreatitis in children. We characterized cases of pediatric pancreatitis, compared with nonbiliary cases, examined differences presentation between younger and older children, studied features distinguishing gallstone- from sludge-induced pancreatitis.We evaluated 76 episodes 271 acute children admitted to a tertiary care hospital 1994 2007.Of the 55% had gallstones, 21% sludge, 24% structural defects. Hispanic 2.85 (P = 0.01) 5.59 0.003)...
Histopathologic lesions of the upper gastrointestinal tract (UGT) are common in inflammatory bowel disease (IBD) patients. Pediatric patients have a higher incidence IBD-associated gastritis and duodenitis than do adults. This study aimed to identify histopathologic features duodenal pediatric population that characteristic IBD, compared pathology different etiopathogenesis. We performed retrospective analysis UGT biopsies from with diagnosis (0–18 years age) over 7-year period. identified...
INTRODUCTION: Obesity is common among patients with pediatric Crohn's disease (PCD). Some adult studies suggest obese respond less well to anti-tumor necrosis factor (TNF) treatment. This study sought compares anti-TNF response and levels between normal high body mass index (BMI). METHODS: The COMBINE trial compared monotherapy combination therapy methotrexate in PCD. In this secondary analysis, a comparison of time-to-treatment failure BMI vs Z -score >1, adjusting for prescribed...
Seventy-four children (43 with chronic constipation, 31 constipation and encopresis) treated polyethylene glycol 3350 (PEG) for longer than 3 months were studied to assess long-term efficacy. The mean duration of PEG therapy was 8.4 (range, 3-30). Weekly stool frequency, consistency, symptoms associated improved significantly in all 74 patients. In encopresis, soiling ceased completely 16 patients frequency decreased others. average effective dose 0.7 g/kg/day. Long-term is the treatment...
Goals To test the hypothesis that obese children are at higher risk of having gastroesophageal reflux symptoms compared with nonobese children. Study In this prospective study, 236 (age: 7 to 16 y) were interviewed using a standard questionnaire for and symptom score was calculated. Obesity defined as body mass index (BMI) greater than 95th percentile age sex. One hundred one age-matched sex-matched BMI between 5th served controls. Demographic data collected in all We prevalence rates other...
ABSTRACT Objectives: To assess the safety, efficacy, and acceptance of a 2‐day bowel preparation with polyethylene glycol (PEG) 3350 without electrolytes bisacodyl for colonoscopy in children. Patients Methods: In prospective study, 111 children mean age 11.9 years were given 2 g/kg PEG 5‐mg tablet daily days before colonoscopy. Stool frequency, consistency, adverse effects monitored duration preparation. Compliance quality colonic assessed on day Results: The average stool frequency...
Although gastritis and esophagitis are well studied in children, there is very limited literature on duodenitis children. We aimed to assess the prevalence, etiology, clinical, endoscopic, pathological features a large cohort of unselected children with duodenitis.We reviewed pathology reports all upper endoscopies performed at our institution during 5 years identify duodenitis. Biopsy sections were confirm diagnosis Demographic, endoscopic data, presence associated noted The etiology was...
Multiple gastric polyps have been reported to occur in adults receiving omeprazole therapy. There are little published data children. We report our experience monitoring the gross and histologic appearance of stomach children long-term therapy.This was a retrospective review charts who received for more than 6 months reflux esophagitis between 1989 1998. All patients had repeated endoscopic examinations until healing confirmed then annually thereafter. At endoscopy, mucosal swellings were...
Propionic acidemia (PA) is a severe metabolic disorder of infants and children (1), resulting from defect in the mitochondrial enzyme propionyl-coenzyme A carboxylase (PCC). PA inherited an autosomal recessive manner. Patients experience acidosis, ketosis, seizures, mental retardation. Acute pancreatitis potentially life-threatening inflammatory that has many known inciting factors, including derangements (2,3). However, although acute been associated with (4,5), recurrent rare. We report...
Delays in the operating room (OR) can lead to increased hospital costs as well patient and provider dissatisfaction. Starting first case on time OR potentially prevent subsequent delays. We designed a quality improvement project improve on-time starts pediatric at tertiary care children's hospital.Following collection of baseline data, we formed an interdisciplinary team. analyzed causes delay used Six Sigma methodology Define, Measure, Analyze, Improve, Control. identified key drivers...