A5000154117- Inflammatory Bowel Disease
- Eosinophilic Esophagitis
- Gastrointestinal motility and disorders
- Microscopic Colitis
- Autoimmune and Inflammatory Disorders Research
- Intestinal Malrotation and Obstruction Disorders
- Pancreatitis Pathology and Treatment
- Adolescent and Pediatric Healthcare
- Helicobacter pylori-related gastroenterology studies
- Gastroesophageal reflux and treatments
- IL-33, ST2, and ILC Pathways
- Esophageal and GI Pathology
- Infant Health and Development
- Child Nutrition and Feeding Issues
- Digestive system and related health
- Eosinophilic Disorders and Syndromes
- Intestinal and Peritoneal Adhesions
- Congenital Anomalies and Fetal Surgery
- Adrenal and Paraganglionic Tumors
- Pharmaceutical studies and practices
- Acute Lymphoblastic Leukemia research
- Metabolism and Genetic Disorders
- Glycogen Storage Diseases and Myoclonus
- Congenital gastrointestinal and neural anomalies
- Renal function and acid-base balance
Children's Hospital of The King's Daughters
2016-2024
Eastern Virginia Medical School
2016-2023
Children's Specialty Group
2023
Penn State Milton S. Hershey Medical Center
2018
University of Arizona
2010-2014
Indiana University School of Medicine
2009-2012
Indiana University – Purdue University Indianapolis
2009-2012
Indiana University
2009-2010
University School
2009
Cleveland Clinic
2006
INTRODUCTION: Obesity is common among patients with pediatric Crohn's disease (PCD). Some adult studies suggest obese respond less well to anti-tumor necrosis factor (TNF) treatment. This study sought compares anti-TNF response and levels between normal high body mass index (BMI). METHODS: The COMBINE trial compared monotherapy combination therapy methotrexate in PCD. In this secondary analysis, a comparison of time-to-treatment failure BMI vs Z -score >1, adjusting for prescribed...
Esophageal Crohn disease (ECD) is more common than it was originally thought to be. Only limited information, however, available regarding its significance and effect on clinical course in the pediatric population. The aim of study determine prevalence ECD our patient population compare features severity among patients with nonesophageal (NECD).Medical records all diagnosed during a 12-year period based specific endoscopic histological criteria were reviewed compared random group NECD.During...
Some patients with eosinophilic esophagitis (EE) (>15 eosinophils/high-power field on esophageal mucosal biopsies and lack of response to acid suppression and/or normal pH probe study) demonstrate incidental inflammation the gastric mucosa. It is unclear whether EE (EE-N) are phenotypically different from abnormalities (EE-A) (ie, >10 eos/hpf biopsies). The aim study was compare clinical features therapy among EE-N EE-A.Medical records all EE-A a random group diagnosed during an 8-year...
Colonic manometry has been used to assess colonic neuromuscular integrity in pediatric patients with severe constipation unresponsive standard medical therapy and tailor their treatment plans. There are presently no available protocols for conducting studies. The aim of the present study was determine whether studies can be conducted on same day motility catheters placed compare effects inhaled sevoflurane versus intravenous propofol, during catheter placement, motility.Twenty patients,...
Human leukocyte antigen (HLA) DQA1*05 has been associated with the development of anti-drug antibodies (ADA) to tumor necrosis factor antagonists (anti-TNFα) and treatment failure among adults Crohn's disease (CD). However, findings from other studies have inconsistent limited pediatric data. We analyzed banked serum patients CD aged <21 years enrolled in clinical outcomes Methotrexate Binary Therapy practice, a multicenter, prospective randomized trial anti-TNFα monotherapy vs combination...
After completing this article, readers should be able to: The primary function of the small intestine is digestion and absorption ingested nutrients. term malabsorption refers to impairment in one or more substances by intestine.Malabsorptive disorders include numerous clinical entities that may result chronic diarrhea, abdominal distention, failure thrive. Although diarrhea a key feature malabsorption, it not apparent at presentation; only symptom poor growth. pediatrician must recognize...
CASE REPORT A 12-month-old boy with past medical history significant for constipation and gastroesophageal reflux presented to our emergency room symptoms of persistent vomiting progressing into hematemesis over a 2-day period. Physical examination was benign. Hemoglobin level reassuring at 11.6 gm/dL. Patient admitted further evaluation management. An upper gastrointestinal study oral contrast revealed normal anatomy. As he advanced regular diet, started having emesis again 24 hours after...
Abstract Objectives Data driven strategies for acute pancreatitis (AP) in pediatrics are limited; adult data suggests lactated ringers (LR) compared to normal saline (NS) resulted favorable outcomes, but has not been studied pediatrics. Our objective was evaluate the efficacy of LR during first 48 h an AP episode with NS. Study Design A multisite randomized controlled clinical trial, from 2015 2020 (Clinical Trials.gov NCT03242473). Patients were exclusively or NS h. Primary outcomes serial...
Abstract Background Higher drug levels and combination therapy with low-dose oral methotrexate (LD-MTX) may reduce anti-tumor necrosis factor (TNF) treatment failure in pediatric Crohn’s disease. We sought to (1) evaluate whether LD-MTX was associated higher anti-TNF levels, (2) associations between subsequent failure, (3) explore the effect of on maintenance remission among patients therapeutic (&gt;5 µg/mL for infliximab &gt;7.5 adalimumab). Methods conducted a post hoc analysis...
Mepolizumab is a humanized monoclonal antibody that binds specifically to and inactivates protein cell messenger termed IL-5, which plays major role in the proliferation, maturation, activation survival of eosinophils. As result, mepolizumab has been studied number eosinophil-associated diseases, such as asthma, hypereosinophilic syndrome eosinophilic esophagitis (EE). EE clinical entity characterized by infiltration esophagus (≥15 eosinophils/high power field one or more fields) absence...
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